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This page gives an overview of the main '''PACE trial documents'''. These include the [[PACE trial]]'s full protocol, therapist manuals, participant newsletters and meeting minutes of the [[PACE Trial Steering Committee|trial steering committee]] and [[PACE Trial Management Group|trial management group]]. == Protocol == * [https://www.s4me.info/docs/PACEProtocolSearchable.pdf PACE trial protocol: Final version 5.0, 01.02.2006] == Manuals == === For therapists === * [https://me-pedia.org/images/6/65/Apt-therapist-manual.pdf Cox et al. 2004. Manual for Therapists Adaptive Pacing Therapy (APT) for CFS/ME.] * [https://me-pedia.org/images/b/b4/PACE-cbt-therapist-manual.pdf Burgess & Chalder, 2004. Manual for Therapists Cognitive Behavioral Therapy (CBT) for CFS/ME.] * [https://me-pedia.org/images/8/89/PACE-get-therapist-manual.pdf Bavinton et al. 2004. Manual for Therapists Graded Exercise Therapy (GET) for CFS/ME]. === For participants === * [https://me-pedia.org/images/8/86/Apt-participant-manual.pdf Cox et al. 2004. Manual for Participants Adaptive Pacing Therapy (APT) for CFS/ME.] * [https://me-pedia.org/images/7/7a/PACE-cbt-participant-manual.pdf Burgess & Chalder, 2004. Manual for Participants Cognitive Behavioral Therapy (CBT) for CFS/ME.] * [https://me-pedia.org/images/d/d4/PACE-get-participant-manual.pdf Bavinton et al. 2004. Manual for Participants Graded Exercise Therapy (GET) for CFS/ME.] === For doctors === * [https://me-pedia.org/images/6/65/Ssmc-doctor-manual.pdf Murphy et al. 2004. Manual for doctors standardised specialist medical care (SSMC).] == Newsletters == * [https://www.me-pedia.org/images/e/e8/Participants%27_newsletter_Issue_1_June_2006_PACE_trial.pdf Participants' newsletter Issue 1 June 2006] * [https://www.me-pedia.org/images/6/66/Participants%27_newsletter_Issue_2_March_2007_PACE_trial.pdf Participants' newsletter Issue 2 March 2007] * [https://www.me-pedia.org/images/a/a0/Participants%27_newsletter_Issue_3_December_2008_PACE_trial.pdf Participants' newsletter Issue 3 December 2008] * [https://www.me-pedia.org/images/6/68/Participants%27_newsletter_Issue_4_February_2011_PACE_trial.pdf Participants' newsletter Issue 4 February 2011] == Trial Steering Committee == :[https://www.me-pedia.org/images/f/f4/1._Trial_Steering_Committee_Meeting_22nd_Apr_2004.pdf 1. Trial Steering Committee Meeting 22nd Apr 2004] :[https://www.me-pedia.org/images/e/e7/2._Trial_Steering_Committee_Meeting_27th_Sep_2004.pdf 2. Trial Steering Committee Meeting 27th Sep 2004] :[https://www.me-pedia.org/images/0/04/3._Trial_Steering_Committee_Meeting_29th_Jun_2005.pdf 3. Trial Steering Committee Meeting 29th Jun 2005] :[https://www.me-pedia.org/images/9/9b/4._Trial_Steering_Committee_Meeting_23rd_Jan_2006.pdf 4. Trial Steering Committee Meeting 23rd Jan 2006] :[https://www.me-pedia.org/images/9/94/5._Trial_Steering_Committee_Meeting_17th_Jul_2006.pdf 5. Trial Steering Committee Meeting 17th Jul 2006] :[https://www.me-pedia.org/images/0/0b/6._Trial_Steering_Committee_Meeting_27th_Jun_2007.pdf 6. Trial Steering Committee Meeting 27th Jun 2007] :[https://www.me-pedia.org/images/8/88/7._Trial_Steering_Committee_Meeting_9th_Apr_2008.pdf 7. Trial Steering Committee Meeting 9th Apr 2008] :[https://www.me-pedia.org/images/7/7f/8._Trial_Steering_Committee_Meeting_29th_Apr_2009.pdf 8. Trial Steering Committee Meeting 29th Apr 2009] :[https://www.me-pedia.org/images/4/40/9._Trial_Steering_Committee_Meeting_10th_Sep_2010.pdf 9. Trial Steering Committee Meeting 10th Sep 2010.] == Trial Management Group == MInutes from the trial managment group were obtained through a Freedom of Information request. For more information see the following thread on the forum Science for ME: [https://www.s4me.info/threads/pace-trial-tsc-and-tmg-minutes-released.3150/ "PACE trial TSC and TMG minutes released."] [https://www.me-pedia.org/images/c/cd/20020607_Draft_minutes_of_PACE_team_meeting.pdf Draft minutes of PACE team meeting of 7.6.02] * [https://www.me-pedia.org/images/7/7c/20030509_minute~1.pdf TMG meeting 1] * [https://www.me-pedia.org/images/a/a3/20030905_TMG_-2.pdf TMG meeting 2] * [https://www.me-pedia.org/images/2/23/20031113_TMG_-3.pdf TMG meeting 3] * [https://www.me-pedia.org/images/3/31/20040123_TMG_-4.pdf TMG meeting 4] * [https://www.me-pedia.org/images/e/ee/20040220_TMG_-5.pdf TMG meeting 5] * [https://www.me-pedia.org/images/1/1b/20040322_TMG_-6.pdf TMG meeting 6] * [https://www.me-pedia.org/images/6/67/20040507_TMG_-7.pdf TMG meeting 7] * [https://www.me-pedia.org/images/0/0c/20040614_TMG_-8.pdf TMG meeting 8] * [https://www.me-pedia.org/images/4/4f/20040708_TMG_-9.pdf TMG meeting 9] * [https://www.me-pedia.org/images/9/9f/20040915_TMG_-10.pdf TMG meeting 10] * [https://www.me-pedia.org/images/4/4a/20041104_TMG_-11.pdf TMG meeting 11] * [https://www.me-pedia.org/images/9/9a/20041210_TMG_-12.pdf TMG meeting 12] * [https://www.me-pedia.org/images/1/12/20050210_TMG_-13.pdf TMG meeting 13] * [https://www.me-pedia.org/images/4/40/20050428_TMG_-14.pdf TMG meeting 14] * [https://www.me-pedia.org/images/8/82/20050615_TMG_-15.pdf TMG meeting 15] * [https://www.me-pedia.org/images/7/76/20050914_TMG_-16.pdf TMG meeting 16] * [https://www.me-pedia.org/images/6/6c/20051117_TMG_-17.pdf TMG meeting 17] * [https://www.me-pedia.org/images/5/59/20060208_TMG_-18.pdf TMG meeting 18] * [https://www.me-pedia.org/images/a/ac/20060426_TMG_-19.pdf TMG meeting 19] * [https://www.me-pedia.org/images/d/dc/20060712_TMG_-20.pdf TMG meeting 20] * [https://www.me-pedia.org/images/d/d4/20061012_TMG_-21.pdf TMG meeting 21] * [https://www.me-pedia.org/images/e/ef/20070208_TMG_-22.pdf TMG meeting 22] * [https://www.me-pedia.org/images/9/95/20070509_TMG_-23.pdf TMG meeting 23] * [https://www.me-pedia.org/images/6/6d/20070920_TMG_-24.pdf TMG meeting 24] * [https://www.me-pedia.org/images/d/da/20071211_TMG_-25.pdf TMG meeting 25] * [https://www.me-pedia.org/images/2/2d/20080213_TMG_-26.pdf TMG meeting 26] * [https://www.me-pedia.org/images/4/42/20080508_TMG_-27.pdf TMG meeting 27] * [https://www.me-pedia.org/images/c/c1/20080917_TMG_-28.pdf TMG meeting 28] * [https://www.me-pedia.org/images/a/a3/20081204_TMG_-29.pdf TMG meeting 29] * [https://www.me-pedia.org/images/4/41/20090311_TMG_-30.pdf TMG meeting 30] * [https://www.me-pedia.org/images/f/fc/20090623_TMG_-31.pdf TMG meeting 31] * [https://www.me-pedia.org/images/a/ac/20091104_TMG_-32.pdf TMG meeting 32] * [https://www.me-pedia.org/images/8/8f/20100210_TMG_-33.pdf TMG meeting 33] == Other documents == * [https://www.me-pedia.org/images/c/c7/Consent_forms_PACE_trial.pdf Full Trial Consent Form] * [https://www.me-pedia.org/images/3/34/Invitation_to_join_the_PACE_trial.pdf invitation to join the PACE trial] * [https://www.me-pedia.org/images/8/8f/Guidance_for_researchers_requesting_access_to_data_from_the_PACE_trial.pdf Guidance for researchers requesting access to data from the PACE trial] * [https://www.me-pedia.org/images/b/bd/HRA_The_PACE_trial_and_the_Commitee%27s_inquiry_on_research_integrity.pdf HRA The PACE trial and the Commitee's inquiry on research integrity] * [https://www.me-pedia.org/images/3/3a/The_PACE_Trial%2C_analysis_of_primary_outcomes_using_composite_measures_of_improvement.pdf Analysis of primary outcomes using composite measures of improvement] * [https://web.archive.org/web/20190226100929/https://www.qmul.ac.uk/wolfson/research-projects/current-projects/projects/pace-trial.html FAQ answered by the PACE team.] == Freedom of information requests for PACE trial data == This section gives an overview of several Freedom of Information (FOI) requests regarding the PACE-trial. This inventory is not exhaustative and it is possible that several FOI requests are not yet listed below. === Neil Riley for the ME Association === * [https://web.archive.org/web/20190225102003/https://www.meassociation.org.uk/2011/05/6171/ PACE Trial – text of joint letter calling for more information. The ME Association, the Young ME Sufferers Trust and the West Midlands ME Groups Consortium. 24 May 2011.] * [https://www.me-pedia.org/images/0/01/FOI_PACE_trial_data_by_the_ME_Association.pdf Response from Paul Smallcombe of Queen Mary University of London to Neil Riley of the ME Association. PACE trial data. 16 June 2011.] === Mr. Courtney: recovery rates === * [https://web.archive.org/web/20190225115952/https://www.whatdotheyknow.com/request/request_for_raw_data_from_the_pa FOI request from Mr. Courtney to Medical Research Council. Request for raw data from the PACE Trial. 15 May 2011.] * [https://www.whatdotheyknow.com/request/request_for_raw_data_from_the_pa_2#incoming-191831 FOI request from Mr. Courtney to Queen Mary Unversity of London. Request for raw data from the PACE Trial. 9 June 2011.] * [https://web.archive.org/web/20190225121646/https://www.whatdotheyknow.com/request/request_for_deterioration_rates FOI Request from Mr. Courtney to Queen Mary University of London. Request for deterioration rates for PACE Trial. 29 March 2012] * [https://web.archive.org/web/20190225102517/https://www.whatdotheyknow.com/request/pace_trial_recovery_rates_and_po FOI request from Mr. Courtney to Queen Mary University of London. PACE Trial: Recovery Rates and Positive Outcome Rates. 26 Ocotober 2012.] * [https://web.archive.org/save/https://www.whatdotheyknow.com/request/the_pace_trial_the_normal_range FOI request from Mr. Courtney to Queen Mary University of London. The PACE Trial - the 'normal range' data analysis. 4 November 2012.] * [https://web.archive.org/web/20190225102314/https://www.whatdotheyknow.com/request/pace_trial_recovery_rates_and_po_2 FOI request from Mr. Courtney to Queen Mary University of London. PACE Trial: Recovery Rates and Positive Outcome Rates (repeat request). 23 October 2013.] * [https://web.archive.org/web/20190225203705/https://www.whatdotheyknow.com/request/pace_trial_recovery_rates_and_po_2 FOI request from Mr. Courtney to Queen Mary University of London. PACE Trial: Recovery Rates and Positive Outcome Rates (repeat request) 29 October 2013.] === Alem Matthees: Selected data on PACE Trial participants === *[https://web.archive.org/web/20190225101002/https://www.whatdotheyknow.com/request/selected_data_on_pace_trial_part FOI request from Alem Matthees to Queen Mary University of London. Selected data on PACE Trial participants. 24 March 2014.] === Ann Sheridan: data for the 6 minute walking test === * [https://web.archive.org/web/20190223230233/https://www.whatdotheyknow.com/request/6min_walking_test_data_recovered FOI request from Anne Sheridan to Queen Mary University of London. 6min walking test data - Recovered patients in PACE trial. 3 September 2013.] * [https://web.archive.org/web/20190223225858/https://www.whatdotheyknow.com/request/raw_data_for_6mwt FOI request from Anne Sheridan to Queen Mary University of London. Raw data for 6mwt. 30 May 2014.] * [https://web.archive.org/web/20190223225335/https://www.whatdotheyknow.com/request/raw_6mwt_data_after_treatment FOI request from Anna Sheridan to Queen Mary University of London. Raw 6mwt Data after treatment. 1 November 2015] === Graham McPhee: data for the fitness test === * [https://web.archive.org/web/20190225100232/https://www.whatdotheyknow.com/request/fitness_data_for_pace_trial FOI request from Graham McPhee to Queen Mary University of London. Fitness data for PACE trial. 29 June 2015.] === Robin Ellis destroyal of raw data === * [https://web.archive.org/web/20190225120249/https://www.whatdotheyknow.com/request/pace_trial_raw_data FOI request from Robin Ellis to Queen Mary University London. PACE trial raw data. 22 July 2016.] === Kathryn Dickenson objective data === * [https://web.archive.org/web/20190225203129/https://www.whatdotheyknow.com/request/cfs_pace_what_story_does_the_obj FOI request from Kathryn Dickenson to Queen Mary University of London. CFS - PACE what story does the objective data tell? 5 May 2017.] * [https://web.archive.org/web/20190225114244/https://www.whatdotheyknow.com/request/cfs_pace_trial_objective_data_en FOI request from Kathryn Dickenson to Queen Mary University of London. CFS - PACE trial objective data enable comparison with patients own objective data. 6 May 2017.] * [https://web.archive.org/web/20190225122256/https://www.whatdotheyknow.com/request/cfs_pace_where_is_the_objective FOI request from Kathryn Dickenson to Queen Mary University of London. CFS - PACE where is the objective data? 6 June 2017.] * [https://web.archive.org/save/https://www.whatdotheyknow.com/request/cfs_pace_permission_to_drop_more#incoming-1040974 FOI request from Kathryn Dickenson to Medical Research Council. CFS - PACE permission to drop more than 50% objective outcome measures. 7 June 2017.] * [https://web.archive.org/web/20190225210130/https://www.whatdotheyknow.com/request/cfs_a_small_of_the_objective_phy FOI request from Kathryn Dickenson to Medical Research Council. CFS - a small % of the objective physical and physiological data from PACE trial. 13 June 2017.] * [https://web.archive.org/web/20190225203925/https://www.whatdotheyknow.com/request/cfs_a_small_of_the_objective_phy_2 FOI request from Kathryn Dickenson to Queen Mary University of London. CFS - a small % of the objective physical and physiological data from PACE trial (6 minute walk test already in public domain). 27 July 2017.] * [https://web.archive.org/web/20190225205231/https://www.whatdotheyknow.com/request/cfs_a_request_for_even_less_obje FOI request from Kathryn Dickenson to Queen Mary University of London. CFS- a request for even less objective info from the PACE trial just the STEP test results at baseline and 52 weeks. 7 Augustus 2017]. * [https://web.archive.org/web/20190225205837/https://www.whatdotheyknow.com/request/cfs_the_volume_of_objective_data FOI request from Kathryn Dickenson to Queen Mary University of London. CFS- the volume of objective data was narrowed down many times how was it determined it would take more than 18 hours to provide the data. 6 September 2017.] * [https://web.archive.org/save/https://www.whatdotheyknow.com/request/csf_did_dwp_authorise_the_droppi FOI request from Kathryn Dickenson to Queen Mary University of London. CSF- did DWP authorise the dropping of objective measures of physical capacity. 12 September 2017.] == Other FOI requests == === 2011 === * [https://web.archive.org/web/20190225120934/https://www.whatdotheyknow.com/request/part_funding_of_the_pace_trial_b FOI request from D. Benyon to Department for Work and Pensions. Part funding of the PACE trial by the DWP. 2 March 2011.] === 2012 === * [https://web.archive.org/web/20190225121059/https://www.whatdotheyknow.com/request/the_pace_trial_white_et_al_2011 FOI request from Peter Kemp to Medical Research Council. The PACE Trial. White, et al. 2011. 14 October 2012.] === 2013 === === 2014 === * [https://web.archive.org/web/20190225122353/https://www.whatdotheyknow.com/request/timing_of_changes_to_pace_trial FOI request from Alem Matthees to Queen Mary University of London. Timing of changes to PACE Trial recovery criteria. 26 April 2014.] === 2015 === * [https://web.archive.org/web/20190225204325/https://www.whatdotheyknow.com/request/pace_results_for_cfs_do_they_app FOI request from Robin Ellis to Queen Mary University of London. PACE results for CFS - do they apply to people with the neurological disorder, ME? 18 December 2015.] === 2016 === * [https://web.archive.org/web/20190225120654/https://www.whatdotheyknow.com/request/when_were_the_mrc_informed_that FOI request from Peter Kemp to Medical Research Council. When were the MRC informed that the PACE Trial Primary Outcome Measures of 'Positive Outcome' and 'Recovery' were eliminated from the Research Protocol. 6 September 2016.] * [https://web.archive.org/web/20190225115359/https://www.whatdotheyknow.com/request/funding_for_queen_mary_universit FOI request from John Slater to Department for Work and Pensions. Funding for Queen Mary University of London "PACE Trial" FOIA case. 3 October 2016.] * [https://web.archive.org/web/20190225120538/https://www.whatdotheyknow.com/request/action_as_a_result_of_the_admiss_2 FOI request from Dave to King's College London. Action as a result of the admission the PACE analysis was misleading? 8 November 2016.] * [https://web.archive.org/save/https://www.whatdotheyknow.com/request/any_actions_resulting_from_misle#outgoing-605197 FOI request from Dave to University of Oxford. Any actions resulting from misleading PACE publications? 8 November 2016.] * [https://web.archive.org/web/20190225202541/https://www.whatdotheyknow.com/request/action_as_a_result_of_the_admiss FOI request from Dave to Queen Mary University of London. Action as a result of the admission the PACE analysis was misleading? 8 November 2016.] * [https://web.archive.org/web/20190225202915/https://www.whatdotheyknow.com/request/cfs_changing_rct_outcomes_to_get FOI request from George Jenson to King's College London. CFS - Changing RCT outcomes to get desired results- Any harrassment/threats actually happen?- PACE what do they think now? _Were any expert exercise physiologists involved in the GET program? 15 November 2016.] * [https://web.archive.org/web/20190225121822/https://www.whatdotheyknow.com/request/cfs_micheal_sharpe_action_after FOI request from George Jenson to University of Edingbrough. CFS - Micheal Sharpe - Action after his admission that the PACE trial's results were "cooked" and misleading. 18 November 2016.] * [https://web.archive.org/web/20190225122120/https://www.whatdotheyknow.com/request/cfs_misleading_reports_on_effect FOI request from George Jenson to Oxford University Hospitals NHS Trust. 18 November 2016.] * [https://web.archive.org/web/20190225120829/https://www.whatdotheyknow.com/request/fraudulent_action_by_qmul FOI request from Freda Fogget to Queen Mary University of London. Fraudulent action by QMUL.1 December 2016.] * [https://web.archive.org/save/https://www.whatdotheyknow.com/request/cfs_correspondence_on_the_depart#outgoing-650994 FOI request from George Jenson to Department of Health and Social Care. CFS correspondence on the Department's view of the PACE trial. 13 December 2016.] === 2017 === * [https://web.archive.org/save/https://www.whatdotheyknow.com/request/cfs_misleading_and_poor_quality FOI request from Dave to Queen Mary University of London. CFS- misleading and poor quality trial design and results - remedies. 30 March 2017.] * [https://web.archive.org/web/20190225203429/https://www.whatdotheyknow.com/request/cfs_how_was_5_million_pounds_spe FOI request from Freda Frogget to Medical Research Council. CFS - how was 5 million pounds spent on the PACE trial and the 2/3millions on the FINE trial. 22 May 2017.] * [https://web.archive.org/web/20190225115546/https://www.whatdotheyknow.com/request/cfs_what_physicalphysiological_e FOI request from Kathryn Dickenson to Queen Mary University of London. CFS- What physical/physiological entry and outcome data did PACE authors undertake to collect, to "win" 5 million pounds. 5 July 2017.] === 2018 === * [https://web.archive.org/save/https://www.whatdotheyknow.com/request/dwp_funding_of_pace_trial FOI request from G. Ryan to Department for Work and Pensions. DWP funding of PACE trial. 24 February 2018.] * [https://web.archive.org/save/https://www.whatdotheyknow.com/request/dohsc_funding_of_pace_trial FOI request from G. Ryan to Department of Health and Social Care. DoHSC funding of PACE trial. 24 February 2018.] * [https://web.archive.org/web/20190225205709/https://www.whatdotheyknow.com/request/mrc_funding_of_the_pace_trial FOI request from G. Ryan to Medical Research Council. MRC funding of the PACE trial. 13 March 2018.] * [https://web.archive.org/save/https://www.whatdotheyknow.com/request/funding_of_pace_trial#outgoing-820271 FOI request from G. Ryan to Queen Mary University of London. Funding of PACE trial. 20 March 2018.] * [https://web.archive.org/web/20190225210007/https://www.whatdotheyknow.com/request/cfs_nihr_investigators_misrepres FOI request from George Jenson to Department of Health and Social Care. CFS - NIHR investigators misrepresenting the effectiveness of CBT and GET for people with CFS. 18 November 2018.] == Information Commissioner's Office Decision notices == This section gives an overview of several Information Commissioner's Office (ICO) decision notices. This inventory however is not exhaustative and it is possible that several ICO rulings are not yet listed below. * [https://www.me-pedia.org/images/c/c8/ICO_Reference_FS50458231._9_January_2013.pdf ICO Decision notice. Jan 9, 2013. Reference FS50458231.] * [https://www.me-pedia.org/images/7/75/ICO_Reference_FS50463661._9_January_2013.pdf ICO Decision notice. Jan 9, 2013. Reference FS50463661.] * [https://www.me-pedia.org/images/1/1f/ICO_Reference_FS50514995._23_January_2014..pdf ICO Decision notice. 23 January 2014. Reference FS50514995.] * [https://www.me-pedia.org/images/e/e5/ICO_Reference_FS50558352._18_Mach_2015..pdf ICO Decision notice. 18 Mach 2015. Reference FS50558352.] * [https://www.me-pedia.org/images/f/f6/ICO_Reference_FS50673373._1_February_2018.pdf ICO Decision notice. 1 February 2018. Reference FS50673373.] * [https://www.me-pedia.org/images/1/15/ICO_Reference_FS50687719._20_February_2018..pdf ICO Decision notice. 20 February 2018. Reference FS50687719.] * [https://www.me-pedia.org/images/d/d4/ICO_Reference_FS50696884._14_March_2018..pdf ICO Decision notice. 14 March 2018. Reference FS50696884.] * [https://www.me-pedia.org/images/9/94/ICO_Reference_FS50721768._23_May_2018..pdf ICO Decision notice. 23 May 2018. Reference FS50721768.] * [https://www.me-pedia.org/images/3/33/ICO_Reference_FS50735928._17_October_2018..pdf ICO Decision notice. 17 October 2018. Reference FS50735928.] * [https://www.me-pedia.org/images/2/24/ICO_Reference_FS50748585._7_November_2018.pdf ICO Decision notice. 7 November 2018. Reference FS50748585.] * [https://www.me-pedia.org/images/8/81/ICO_Reference_FS50742225._13_December_2018..pdf ICO Decision notice. 13 December 2018. Reference FS50742225.] [[Category: Notable studies]] [[Category:Psychological paradigm]] [[Category:History]] == First tier tribunal appeals == * [https://www.me-pedia.org/images/4/41/PACE-Trial-tribunal-decision-22-August-213.pdf First tier tribunal. Appeal Number EA/2013/0019. Appelant: John Mitchell. Respondent: The Information Commissioner. Second Respondent: Queen Mary University of London.] * [https://me-pedia.org/images/0/0d/First_tier_tribunal_%282015%29_appeal_number_EA-2015-0269.PDF First tier tribunal. Appeal Number EA/2015/0269. Appelant: Queen Mary University of London. Respondent: The Information Commissioner. Second Respondent: Alem Matthees.] == PACE trial published papers == === Main papers === {| class="wikitable" !Year !Journal !Content !Full reference |- |2007 |BMC Neurology |Protocol |[https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-7-6 White PD, Sharpe MC, Chalder T, DeCesare JC, Walwyn R; PACE trial group. Protocol for the PACE trial: a randomised controlled trial of adaptive pacing, cognitive behaviour therapy, and graded exercise, as supplements to standardised specialist medical care versus standardised specialist medical care alone for patients with the chronic fatigue syndrome/myalgic encephalomyelitis or encephalopathy. BMC Neurol. 2007 Mar 8;7:6.] |- |2011 |The Lancet |Main results |[https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)60096-2/fulltext White PD, Goldsmith KA, Johnson AL, Potts L, Walwyn R, DeCesare JC, et al. Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. Lancet. 2011 Mar 5;377(9768):823-36.] |- |2012 |PLOS ONE |Cost-effectiveness |[https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040808 McCrone P, Sharpe M, Chalder T, Knapp M, Johnson AL, Goldsmith KA, White PD. Adaptive pacing, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome: a cost-effectiveness analysis. PLoS One. 2012;7(8):e40808.] |- |2013 |Psychological Medicine |Recovery rates |[https://www.cambridge.org/core/journals/psychological-medicine/article/recovery-from-chronic-fatigue-syndrome-after-treatments-given-in-the-pace-trial/6E3A5B37D427239D146C5EB276A11E06 White PD, Goldsmith K, Johnson AL, Chalder T, Sharpe M. Recovery from chronic fatigue syndrome after treatments given in the PACE trial. Psychol Med. 2013 Oct;43(10):2227-35.] |- |2013 |Trials |Statistical analysis plan |[https://trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-14-386 Walwyn R, Potts L, McCrone P, Johnson AL, DeCesare JC, Baber H, et al. A randomised trial of adaptive pacing therapy, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome (PACE): statistical analysis plan. Trials. 2013 Nov 13;14:386.] |- |2014 |Journal of Psychosomatic Research |Adverse events |[https://www.sciencedirect.com/science/article/pii/S0022399914001883 Dougall D, Johnson A, Goldsmith K, Sharpe M, Angus B, Chalder T, White P. Adverse events and deterioration reported by participants in the PACE trial of therapies for chronic fatigue syndrome. J Psychosom Res. 2014 Jul;77(1):20-6.] |- |2015 |Lancet Psychiatry |Mediation analysis |[https://www.sciencedirect.com/science/article/pii/S2215036614000698 Chalder T, Goldsmith KA, White PD, Sharpe M, Pickles AR. Rehabilitative therapies for chronic fatigue syndrome: a secondary mediation analysis of the PACE trial. Lancet Psychiatry. 2015 Feb;2(2):141-52.] |- |2015 |Lancet Psychiatry |Long term follow-up |[https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(15)00317-X/fulltext Sharpe M, Goldsmith KA, Johnson AL, Chalder T, Walker J, White PD. Rehabilitative treatments for chronic fatigue syndrome: long-term follow-up from the PACE trial. Lancet Psychiatry. 2015 Dec;2(12):1067-74.] |} === Other PACE trial papers === {| class="wikitable" !Year !Journal !Content !Full reference |- |2010 |JRSM Open |Psychiatric misdiagnoses |[https://journals.sagepub.com/doi/abs/10.1258/shorts.2010.010042 Lawn T, Kumar P, Knight B, Sharpe M, White PD. Psychiatric misdiagnoses in patients with chronic fatigue syndrome. JRSM Short Rep. 2010 Sep 6;1(4):28.] |- |2011 |Journal of Psychosomatic Research |Testing the Work and Social Adjustment Scale |[https://www.sciencedirect.com/science/article/pii/S0022399911000717?via%3Dihub Cella M, Sharpe M, Chalder T. Measuring disability in patients with chronic fatigue syndrome: reliability and validity of the Work and Social Adjustment Scale. J Psychosom Res. 2011 Sep;71(3):124-8.] |- |2013 |BJPsych Bulletin |History and planning of the PACE trial |[https://www.cambridge.org/core/journals/bjpsych-bulletin/article/planning-implementation-and-publication-of-a-complex-intervention-trial-for-chronic-fatigue-syndrome-the-pace-trial/539F6F7132848EE05207A4E271813C9A White PD, Chalder T, Sharpe M. The planning, implementation and publication of a complex intervention trial for chronic fatigue syndrome: the PACE trial. BJPsych Bull. 2015 Feb;39(1):24-7.] |- |2013 |Psychological Medicine |Cognitions and co-morbid psychiatric diagnoses |[https://www.cambridge.org/core/journals/psychological-medicine/article/cognitions-behaviours-and-comorbid-psychiatric-diagnoses-in-patients-with-chronic-fatigue-syndrome/69BB3E81863E9FAED2CF849725D6CD15 Cella M, White PD, Sharpe M, Chalder T. Cognitions, behaviours and co-morbid psychiatric diagnoses in patients with chronic fatigue syndrome. Psychol Med. 2013 Feb;43(2):375-80.] |- |2013 |International Journal of Therapy and Rehabilitation |Training and supervision of therapists |[https://www.magonlinelibrary.com/doi/pdf/10.12968/ijtr.2013.20.4.180 Cox D, Burgess M, Chalder T, Sharpe M, White P, Clark L. Training, supervision and therapists' adherence to manual-based therapy. Int J Rehabil Res. 2013;20(4):180-186.] |- |2014 |Psychological Medicine |Pain |[https://www.cambridge.org/core/journals/psychological-medicine/article/pain-in-chronic-fatigue-syndrome-response-to-rehabilitative-treatments-in-the-pace-trial/94AA6AF17C2D8C933F8FD3941389A574 Bourke JH, Johnson AL, Sharpe M, Chalder T, White PD. Pain in chronic fatigue syndrome: response to rehabilitative treatments in the PACE trial. Psychol Med. 2014 May;44(7):1545-52.] |- |2016 |Journal of Psychosomatic Research |The use of complementary and alternative treatments |[https://www.sciencedirect.com/science/article/pii/S0022399916303270?via%3Dihub Lewith G, Stuart B, Chalder T, McDermott C, White PD. Complementary and alternative healthcare use by participants in the PACE trial of treatments for chronic fatigue syndrome. J Psychosom Res. 2016 Aug;87:37-42.] |- |2017 |Psychological Medicine |Analysis of subgroups |[https://www.cambridge.org/core/journals/psychological-medicine/article/heterogeneity-in-chronic-fatigue-syndrome-empirically-defined-subgroups-from-the-pace-trial/4CB7DD589F3B23240A11131C8E8E2046 Williams TE, Chalder T, Sharpe M, White PD. Heterogeneity in chronic fatigue syndrome - empirically defined subgroups from the PACE trial. Psychol Med. 2017 Jun;47(8):1454-1465.] |} For more information on the PACE trial publications and documents, visit the [https://www.s4me.info/threads/a-general-thread-on-the-pace-trial.807/ discussion on the webforum Science for ME.]
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