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Nudix hydrolase 15
(section)
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==Drug responses and genetic testing== [[Genetic testing]] for NUDT15 aims to improve clinical outcomes and reduce harm in people with inherited genetic mutations known to agfect drug responses.<ref name="pharmacogenomics2022">{{Citation |url=https://www.bps.ac.uk/getmedia/b43a3dca-1bbf-4bff-9379-20bef9349a8c/Personalised-prescribing-full-report.pdf.aspx | last = ((Royal College of Physicians)) | last2 = ((British Pharmacological Society)) | title = Personalised prescribing: using pharmacogenomics to improve patient outcomes. Report of a working party. |location=London|publisher=RCP and BPS | date = 2022}}</ref> There are a wide variety of different varoations, which may be broadly grouped into: *Normal Metabolizer: Two copies of a normal function allele in the NUDT15 gene. *Intermediate Metabolizer: One copy of a normal function allele and one copy of a no function allele in the NUDT15 gene. *Poor Metabolizer: Two copies of no function alleles, low or absent activity of NUDT15. At high risk for toxicity with normal doses of thiopurine drugs. *Possible Intermediate Metabolizer: One copy of a normal function allele and one copy of an uncertain function allele in the NUDT15 gene. At risk for myelosuppression with thiopurine drugs. *Possible Poor Metabolizer: Two copies of uncertain function alleles or one copy of an uncertain function allele and one no function allele in the NUDT15 gene. At high risk for toxicity with thiopurine drugs. * Indeterminate-Phasing Positive: Uncharacterized allele composition.<ref name="Classifications">{{Cite web | title = Nudix Hydrolase 15 (NUDT15) Genotyping | url=https://www.rprdx.com/wp-content/uploads/2019/04/NUDT15_TestSpecification_190426.pdf |website=RDRX Diagnostics|access-date=2022-04-08}}</ref>
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