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Neuroimmune model
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{{Stub}} {{NeedsImage}} The '''neuroimmune model''' or '''neuro immune hypothesis''' of [[ME/CFS]] proposes that an initial infection and immune activation, which can be caused by a number of different [[Pathogen|pathogens]] results in "a state of chronic peripheral immune activation driven by activated O&NS pathways that lead to progressive damage of self epitopes even when the initial infection has been cleared".<ref name="Morris2013" /> The [[ATP]] deficiency, [[inflammation]] and [[Oxidative and nitrosative pathway|oxidative and nitrosative stress]] are proposed to result from this, and to be the cause of the symptoms characteristic of ME/CFS.<ref name="Morris2013" /> == Theory == == Evidence == == Treatment == ==Notable studies and publications == * 2011, Chronic fatigue syndrome β A neuroimmunological model<ref name="Arnett2011">{{Cite journal | last = Arnett | first = S.V. | authorlink = Simon Arnett | last2 = Alleva | first2 = L.M. | author-link2 = Lisa Alleva | last3 = Korossy-Horwood | first3 = R. | authorlink3 = Rebecca Korossy-Horwood | last4 = Clark | first4 =I.A. | authorlink4 = Ian Clark | date = 2011-07-01 | title = Chronic fatigue syndrome β A neuroimmunological model|url=http://serendipitycat.no/wp-content/uploads/2011/10/Arnett-et-al-2011-CFS-a-nevroimmunological-model.pdf|journal=Medical Hypotheses|volume=77|issue=1 | pages = 77β83|doi=10.1016/j.mehy.2011.03.030|issn=0306-9877|quote=|via=}}</ref> [http://serendipitycat.no/wp-content/uploads/2011/10/Arnett-et-al-2011-CFS-a-nevroimmunological-model.pdf (Full text)] * 2013, A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome<ref name="Morris2013">{{Cite journal | last = Morris | first = Gerwyn | authorlink = Gerwyn Morris | last2 = Maes | first2 = Michael | authorlink2 = Michael Maes | date = Dec 2013 | title = A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/22718491|journal=Metabolic Brain Disease|volume=28|issue=4 | pages = 523β540|doi=10.1007/s11011-012-9324-8|issn=1573-7365|pmid=22718491|quote=|via=}}</ref> [[pubmed:22718491|(Full text)]] *2017, The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref name="Glasson2017">{{Cite journal | last = Glassford | first = Julian A.G. | authorlink = Julian Glassford | authorlink2 = | date = 2017-02-17 | title = The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314655/|journal=Frontiers in Physiology|volume=8|issue=|pages=|doi=10.3389/fphys.2017.00088|issn=1664-042X|pmc=5314655|pmid=28261110|quote=|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314655/#__ffn_sectitle (Full text)] == See also == * [[O&NS pathway]] * [[Gerwyn Morris]] * [[Michael Maes]] * [[:Category:Medical hypotheses|Medical hypotheses]] (category) == Learn more == * [[pubmed:22718491|A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome]]<ref name=":0">{{Cite journal | last = Morris | first = Gerwyn | authorlink = Gerwyn Morris | last2 = Maes | first2 = Michael | authorlink2 = Michael Maes | date = Dec 2013 | title = A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/22718491|journal=Metabolic Brain Disease|volume=28|issue=4 | pages = 523β540|doi=10.1007/s11011-012-9324-8|issn=1573-7365|pmid=22718491|quote=|via=}}</ref> == References == {{Reflist}} [[Category:Medical hypotheses]] [[Category:Immunology]]
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