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GETSET trial
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The '''GETSET''' trial (short for ''Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome'') was a trial investigating the effectiveness of "guided graded exercise self-help" in patients with [[CFS/ME]]. The protocol was published in June 2016.<ref name="getsetprotocol" /> The results were published in June 2017.<ref name="getset" /> ==Researchers== Lead Author [[Lucy Clark]], [[Peter White]], Francesca Pesola, Janice M Thomas, Mario Vergara-Williamson and Michelle Beynon ==Funding== The trial was funded in full by the [[National Institute for Health Research]]'s Research for Patient Benefit programme.<ref name="getsetisrctn" /> ==Protocol== The protocol of the trial was published in ''JMIR Research Protocols'' in June 2016.<ref name="getsetprotocol" /> ==Publications== The results were published on 22 June 2017 in the [[The Lancet|Lancet]]: ''[http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2816%2932589-2/fulltext Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial]<ref>{{Cite journal | last = Clark | first = Lucy V. | last2 = Pesola | first2 = Francesca | last3 = Thomas | first3 = Janice M. | last4 = Vergara-Williamson | first4 = Mario | last5 = Beynon | first5 = Michelle | last6 = White | first6 = PeterD. | date = 2017-07-22 | title = Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial| url = https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)32589-2/abstract|journal=The Lancet|language=English|volume=390|issue=10092 | pages = 363–373|doi=10.1016/S0140-6736(16)32589-2|issn=0140-6736|pmid=28648402}}</ref>'' Commentary was provided by [[Daniel Clauw]] in the Lancet: [http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30577-9/fulltext ''Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome''].<ref>{{Cite journal | last = Clauw | first = Daniel J | author-link = Daniel Clauw | date = Jul 2017 | title = Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome | url =https://linkinghub.elsevier.com/retrieve/pii/S0140673617305779|journal=The Lancet|language=en|volume=390|issue=10092 | pages = 335–336|doi=10.1016/S0140-6736(17)30577-9|pmc=|pmid=|access-date=|quote=|via=}}</ref> The [[Science Media Centre]] provided: [http://www.sciencemediacentre.org/expert-reaction-to-study-on-guided-self-help-graded-exercise-therapy-as-a-treatment-for-chronic-fatigue-syndrome-cfs/ ''Expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS)''].<ref>{{Cite web | url = https://www.sciencemediacentre.org/expert-reaction-to-study-on-guided-self-help-graded-exercise-therapy-as-a-treatment-for-chronic-fatigue-syndrome-cfs/ | title = expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS) {{!}} Science Media Centre|language=en-US|access-date=2020-05-08}}</ref> It was reported in the Telegraph as [http://www.telegraph.co.uk/science/2017/06/22/exercise-can-help-chronic-fatigue-syndrome-study-shows/ Exercise can help chronic fatigue syndrome, study shows] and other media outlets: ''[http://www.emergency-live.com/en/news/defeating-chronic-fatigue-thanks-to-guided-self-help-approach-to-exercise/ Defeating chronic fatigue thanks to guided self-help approach to exercise].''<ref>{{Cite web | url = https://www.emergency-live.com/health-and-safety/defeating-chronic-fatigue-thanks-to-guided-self-help-approach-to-exercise/ | title = Defeating chronic fatigue thanks to guided self-help approach to exercise|website=Emergency Live|language=en-US|access-date=2020-05-08}}</ref> The long term follow-up results were published July 2021 in the Journal of Psychosomatic Research: ''[https://doi.org/10.1016/j.jpsychores.2021.110484 Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial]''.<ref>{{Cite journal | title = Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial| date = 2021-07-01| url = https://www.sciencedirect.com/science/article/pii/S002239992100129X|journal=Journal of Psychosomatic Research|volume=146|pages=110484 | last = Clark | first = Lucy V. | last2 = McCrone | first2 = Paul | last3 = Pesola | first3 = Francesca | last4 = =Vergara-Williamson | first4 = Mario | last5 = White | first5 = Peter D.|language=en|doi=10.1016/j.jpsychores.2021.110484|issn=0022-3999}}</ref> ==Criticism== Dr [[David Tuller]] criticized the trial in the blog post [http://www.virology.ws/2017/06/28/trial-by-error-continued-more-on-graded-exercise-from-peter-white-and-the-lancet/ Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet]. Tuller later also criticized misleading presentation of the long term follow-up results, which presented the results as demonstrating sustained improvement, despite them finding a lack of significant difference between the treated and untreated groups.<ref>{{Cite web | url = https://www.virology.ws/2021/04/06/trial-by-error-getset-study-reports-null-results-for-self-help-graded-exercise-but-declares-success-anyway/ | title = Trial By Error: GETSET Study Reports Null Results for Self-Help Graded Exercise–but Declares Success Anyway|website=www.virology.ws|access-date=2022-11-08}}</ref> The paper was subsequently revised in response to this criticism.<ref>{{Cite journal | title = Corrigendum to “Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial” [Journal of Psychosomatic Research 146 (2021) 110484]| date = 2021-09-01| url = https://www.sciencedirect.com/science/article/pii/S0022399921001872|journal=Journal of Psychosomatic Research|volume=148|pages=110542 | last = Clark | first = Lucy V. | last2 = McCrone | first2 = Paul | last3 = Pesola | first3 = Francesca | last4 = =Vergara-Williamson | first4 = Mario | last5 = White | first5 = Peter D.|language=en|doi=10.1016/j.jpsychores.2021.110542|issn=0022-3999}}</ref> [[Spoonseekerdotcom]] has criticised the GETSET trial.<ref>{{Cite web | url = https://spoonseeker.com/2016/05/23/a-few-notes-on-getset/ | title = A Few Notes on GETSET | last = Spoonseeker | first = Author | date = 2016-05-23 | website = spoonseekerdotcom|language=en|access-date=2020-01-26}}</ref><ref>{{Cite web | url = https://spoonseeker.com/2017/06/29/do-get-yourself/ | title = Do GET Yourself | last = Spoonseeker | first = Author | date = 2017-06-29 | website = spoonseekerdotcom|language=en|access-date=2020-01-26}}</ref><ref>{{Cite web | url = https://spoonseeker.com/2017/07/03/spotlight-on-getset-julie/ | title = Spotlight on GETSET Julie | last = Spoonseeker | first = Author | date = 2017-07-03 | website = spoonseekerdotcom|language=en|access-date=2020-01-26}}</ref> Professor [[Jonathan Edwards]] criticised the study for its "incompetent level of science".<ref>{{Cite web | url = https://forums.phoenixrising.me/threads/trial-by-error-continued-more-on-graded-exercise-from-peter-white-and-the-lancet.52541/ | title = Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet | website = Phoenix Rising ME / CFS Forums|language=en-US|access-date=2020-01-26}}</ref> The [[ME Association]] also criticised the trial in [http://www.meassociation.org.uk/2017/06/me-association-review-getset-fails-to-demonstrate-get-can-significantly-improve-physical-function-28-june-2017/ ME Association Review: GETSET fails to demonstrate GET can significantly improve physical function]. Additional criticism has been published by other patients such as Lou Corsius and [[Cort Johnson]].<ref>{{Cite web | url = https://corsius.wordpress.com/2017/06/23/yet-another-publication-with-misleading-conclusions-from-pace-land/ | title = Yet another publication with misleading conclusions from PACE-land | last = Corsius | first = Lou | date = 2017-06-23 | website = it's about ME|language=nl|access-date=2020-01-26}} </ref><ref>{{Cite web | url = https://www.healthrising.org/blog/2017/06/25/graded-exercise-get-chronic-fatigue-syndrome-underwhelms/ | title = On Your Marks GETSET: Don't Go - Major Graded Exercise ME/CFS Trial Underwhelms (Again) | last = Johnson | first = Cort | date = 2017-06-26 | website = Health Rising|language=en-US|access-date=2020-01-26}} </ref> ==Documents== * Lead author Lucy Clark had previously published a booklet called [[:File:GET booklet web July 2009 2 .pdf | Graded Exercise Therapy - A self-help guide for those with chronic fatigue syndrome/myalgic encephalomyelitis]]. This booklet was apparently distributed to patients in the GETSET trial. ==Learn more == *[https://spoonseeker.com/2016/05/23/a-few-notes-on-getset/ A few notes on GETSET] - Spoonseekerdotcom *[[Graded exercise therapy]] *[[Biopsychosocial model]] ==See also== *[[PACE trial]] ==References== <references> <ref name="getsetisrctn">{{Cite web | url = http://www.isrctn.com/ISRCTN22975026 | title = ISRCTN - ISRCTN22975026: Graded Exercise Therapy guided SElf-help Treatment for CFS/ME | website = isrctn.com|language=en|access-date=2020-01-26}}</ref> <ref name="getsetprotocol">{{Citation | doi = 10.2196/resprot.5395 | volume = 5 | issue = 2 | pages = 70 | last1 = Clark | first1 = Lucy V. | authorlink1 = Lucy Clark | last2 = McCrone | first2 = Paul | authorlink2 = Paul McCrone | last3 = Ridge | first3 = Damien | authorlink3 = Damien Ridge | last4 = Cheshire | first4 = Anna | authorlink4 = Anna Cheshire | last5 = Vergara-Williamson | first5 = Mario | authorlink5 = Mario Vergara-Williamson | last6 = Pesola | first6 = Francesca | authorlink6 = Francesco Pesola | last7 = White | first7 = PeterD. | author-link8 = Peter White | title = Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome (GETSET): Protocol for a Randomized Controlled Trial and Interview Study | journal = JMIR research protocols | date = 2016-06-08 | pmid = 27278762 | pmc = 4917732 }}</ref> <ref name="getset">{{Citation | doi = 10.1016/S0140-6736(16)32589-2 | volume = | issue = | pages = | last1 = Clark | first1 = Lucy V. | authorlink1 = Lucy Clark | last2 = Pesola | first2 = Francesca | authorlink2 = Francesca Pesola | last3 = Thomas | first3 = Janice | authorlink3 = Janice Thomas | last4 = Vergara-Williamson | first4 = Mario | authorlink4 = Mario Vergara-Williamson | last5 = Beynon | first5 = Michelle | authorlink5 = Michelle Beynon | last6 = White | first6 = PeterD. | authorlink6 = Peter White | title = Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial | journal = The Lancet | date = 2017-06-22 | pmid = | pmc = }}</ref> </references> [[Category:Psychological paradigm]] [[Category:Notable studies]]
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