National Centre for Neuroimmunology and Emerging Diseases
The NCNED is a part of Griffith University Health, in south-east Queensland.
In February 2016 the research team led by Donald Staines and Sonya Marshall-Gradisnik announced it had created a diagnostic test for the disease using CD8 T cells. The researchers have submitted patent claims in relation to their discovery.
Professor Sonya Marshall-Gradisnik clarified that 'In response to a number of inquiries of this nature we are pleased to advise that we have both published papers, papers in press, and additional data not for publication, which constitutes commercial-in-confidence'.
- May 2016 - Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients, Biological Research, 2016 49:27. Changes in intracellular signalling.
- Apr 2016 - ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients, Journal of Translational Medicine, 2016:14 97. Changes in intracellular signalling.
- Jan 2016 - Genotype Frequencies of Transient Receptor Potential Melastatin M3 Ion Channels and Acetylcholine Muscarinic M3 Receptor Gene Polymorphisms in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients, Immunology and Immunogenetics Insights, 2016:8 1-2. (small study - 115 people with ME/CFS)
- Dec 2015 - A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis, Hindawi
- Dec 2015 - Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis Scandinavian Journal of Immunology, Volume 83, Issue 1, pages 44–51
- Sep 2015 - Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients, Int J Med Sci, 2015; 12(10): 764–772.
- Aug 2015 - Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients, Journal of Translational Medicine, 201513:299
- Conclusions: Severe CFS/ME patients differed from controls and moderate CFS/ME patients over time and expressed significant alterations in iNKT cell phenotypes, CD8+T cell markers, NK cell receptors and γδT cells at 6 months.
- May 2015 - Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), BMC Immunology, 2015 16:35
- May 2015 - Examination of Single Nucleotide Polymorphisms in Acetylcholine Receptors in Chronic Fatigue Syndrome Patients, Immunology and Immunogenetics Insights, 2015:7 7-20. (small study - 115 people with ME/CFS)
- May 2015 - Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients, Immunology and Immunogenetics Insights, 2015:7 1-6. (small study - 115 people with ME/CFS)
- Apr 2014 - A comparison of health status in patients meeting alternative definitions for chronic fatigue syndrome/myalgic encephalomyelitis, Health and Quality of Life Outcomes, 2014 12:64
- Results: Patients fulfilling the ICC definition reported significantly lower scores (p < 0.05) for physical functioning, physical role, bodily pain, and social functioning than those that only fulfilled the 1994 CDC definition. ICC patients reported significantly greater (p < 0.05) disability across all domains of the WHO DAS 2.0.
The NCNED is supported by the Queensland Government and philanthropic donors.
- Website - NCNED
- Website - Griffith Health
- Twitter - Griffith Health
- 2016, Australian scientists make breakthrough in Chronic Fatigue Syndrome testing, ABC News (Australia), 29 February 2016
- 2016, Screening test for Chronic Fatigue Syndrome on its way, Griffith University, 1 March 2016
- Australian scientists make breakthrough in Chronic Fatigue Syndrome testing, ABC News (Australia), 29 February 2016
- Griffith Uni claims breakthrough on diagnostic test, #MEAction, February 29, 2016
- Screening test for Chronic Fatigue Syndrome on its way, Griffith University, 1 March 2016
- A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis’., Journal of Immunology Research, Volume 2016 (2016), Article ID 9064529, 8 pages
- New Screening Test for ME/CFS Announced by Griffith University, CFS Treatment Guide, 5 Mar 2016
- Chronic fatigue syndrome: new diagnostic tool to speed up treatment and reduce stigma
- A screening test for chronic fatigue syndrome is ready for the public
- Patent AusPat 2015904991, IP Australia, 2 December 2015
- Patent AusPat 2015901567, IP Australia, 1 June 2015
- Biological markers - WO 2016023077 A1
- Statement from NCNED, Griffith University, 1 March 2016
- Letter from Sonya Marshall-Gradisnik, Twitter, 1 March 2016
- NCNED Partnerships