Luis Nacul

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Dr Luis Carlos Nacul is a Clinical Associate Professor and researcher at the London School of Hygiene and Tropical Medicine in London, United Kingdom. He leads the CureME team and the UK ME/CFS biobank. He serves as a Member Substitute for EUROMENE, an international not-for-profit organization for ME/CFS research.

He is a doctor and general practitioner, with training across medicine, epidemiology and public health.[1] In 2018, Dr Nacul was appointed to the review committee for the NICE guidelines for ME/CFS used by the British NHS.[2]

ME/CFS Common Data Element (CDE) Project[edit | edit source]

Dr Nacul serves on the Fatigue Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the National Institute of Neurological Disorders and Stroke and the Centers for Disease Control & Prevention.[3]

Notable studies and writings related to ME/CFS[edit | edit source]

Talks and interviews[edit | edit source]

Online presence[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. London School of Hygiene and Tropical Medicine. "Luis Nacul".
  2. NICE (October 28, 2018). "Committee member list | NICE CG53 CFS/ME guidance update". nice.org.uk. Retrieved October 20, 2018.
  3. "Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster". NIH. Retrieved October 11, 2019.
  4. Osoba, Tolu; Pheby, Derek; Gray, Selena; Nacul, Luis (2007), "The Development of an Epidemiological Definition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome", Journal of Chronic Fatigue Syndrome, 14 (4): 61-84, doi:10.3109/10573320802092112
  5. Nacul, L. C.; Lacerda, E. M.; Pheby, D.; Campion, P.; Molokhia, M.; Fayyaz, S.; Leite, JCDC; Poland, F; Howe, A; de L. Drachler, Maria (2011). "Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care". BMC Medicine. 9 (91). doi:10.1186/1741-7015-9-91. PMC 3170215.
  6. de Carvalho Leite, JC; de L Drachler, M; Killett, A; Kale, S; Nacul, L; McArthur, M; Hong, CS; O'Driscoll, L; Pheby, D; Campion, P; Lacerda, E; Poland, F (2011), "Social support needs for equity in health and social care: a thematic analysis of experiences of people with chronic fatigue syndrome/myalgic encephalomyelitis", International Journal for Equity in Health, 2 (10): 46, doi:10.1186/1475-9276-10-46, PMC 3229491
  7. Nacul, Luis C; Lacerda, Eliana M; Campion, Peter; Pheby, Derek; Drachler, Maria de L; Leite, José C; Poland, Fiona; Howe, Amanda; Fayyaz, Shagufta (May 27, 2011). "The functional status and well being of people with myalgic encephalomyelitis/chronic fatigue syndrome and their carers". BMC Public Health. 11 (1): 402. doi:10.1186/1471-2458-11-402. ISSN 1471-2458. PMC 3123211. PMID 21619607.
  8. Nacul, Luis; O’Donovan, Dominic G; Lacerda, Eliana M; Gveric, Djordje; Goldring, Kirstin; Hall, Alison; Bowman, Erinna; Pheby, Derek (2014). "Considerations in establishing a post-mortem brain and tissue bank for the study of myalgic encephalomyelitis/chronic fatigue syndrome: a proposed protocol". BMC Research Notes. 7 (1): 370. doi:10.1186/1756-0500-7-370. ISSN 1756-0500. PMC 4076507. PMID 24938650.
  9. Nacul, Luis; Lacerda, Eliana M; Kingdon, Caroline C; Curran, Hayley; Bowman, Erinna W (March 1, 2017). "How have selection bias and disease misclassification undermined the validity of myalgic encephalomyelitis/chronic fatigue syndrome studies?". Journal of Health Psychology: 1359105317695803. doi:10.1177/1359105317695803. ISSN 1359-1053. PMC 5581258. PMID 28810428.
  10. Cella, David; Dimmock, Mary; Friedberg, Fred; Lin, Jin-Mann Sally; Nacul, Luis; Saligan, Leorey (December 2017), NINDS/CDC Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Common Data Elements (CDE); Fatigue Subgroup Materials (PDF)
  11. Lacerda, Eliana M.; Kingdon, Caroline C.; Bowman, Erinna W.; Nacul, Luis (2017). "Using a participatory approach to develop and implement the UK ME/CFS Biobank". Fatigue: Biomedicine, Health & Behavior. doi:10.1080/21641846.2018.1396021.
  12. Nacul, Luis; Kingdon, Caroline C.; Bowman, Erinna W.; Curran, Hayley; Lacerda, Eliana M. (2017). "Differing case definitions point to the need for an accurate diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome". Fatigue: Biomedicine, Health & Behavior. 5 (1): 1–4. doi:10.1080/21641846.2017.1273863. ISSN 2164-1846. PMC 5730342. PMID 29250461.
  13. Lacerda, Eliana M; Bowman, Erinna W; Cliff, Jacqueline M; Kingdon, Caroline C; King, Elizabeth C; Lee, Ji-Sook; Clark, Taane G; Dockrell, Hazel M; Riley, Eleanor M; Curran, Hayley; Nacul, Luis (February 20, 2017). "The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis". Open Journal of Bioresources. 4. doi:10.5334/ojb.28. ISSN 2056-5542. PMC 5482226. PMID 28649428.
  14. Kingdon, Caroline C.; Bowman, Erinna W.; Curran, Hayley; Nacul, Luis; Lacerda, Eliana M. (March 13, 2018). "Functional Status and Well-Being in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Compared with People with Multiple Sclerosis and Healthy Controls". PharmacoEconomics - Open. doi:10.1007/s41669-018-0071-6. ISSN 2509-4262.
  15. Estévez-López, Fernando; Castro-Marrero, Jesus; Wang, Xia; Bakken, Inger Johanne; Ivanovs, Andrejs; Nacul, Luis; Sepúlveda, Nuno; Strand, Elin B.; Pheby, Derek; Alegre, José; Scheibenbogen, Carmen; Shikova, Evelina; Lorusso, Lorenzo; Capelli, Enrica; Sekulic, Slobodan; Lacerda, Eliana; Murovska, Modra (September 1, 2018). "Prevalence and incidence of myalgic encephalomyelitis/chronic fatigue syndrome in Europe—the Euro-epiME study from the European network EUROMENE: a protocol for a systematic review". BMJ Open. 8 (9): e020817. doi:10.1136/bmjopen-2017-020817. ISSN 2044-6055. PMID 30181183.
  16. Nacul, Luis Carlos; Mudie, Kathleen; Kingdon, Caroline; Clark, Taane G.; Lacerda, Eliana Mattos (2018). "Hand grip strength as a clinical biomarker for ME/CFS and disease severity". Frontiers in Neurology. 9. doi:10.3389/fneur.2018.00992. ISSN 1664-2295.
  17. Lacerda, Eliana; Mudie, Kathleen; Butterworth, Jack D.; Kingdon, Caroline C.; O'Boyle, Shennae; Nacul, Luis (December 4, 2018). "The UK ME/CFS Biobank: A Disease-Specific Biobank for Advancing Clinical Research Into Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Frontiers in Neurology. 9. doi:10.3389/fneur.2018.01026. ISSN 1664-2295. PMID 30564186.
  18. Lacerda, Eliana M.; McDermott, Clare; Kingdon, Caroline C.; Butterworth, Jack; Cliff, Jacqueline M.; Nacul, Luis (January 10, 2019). "Hope, disappointment and perseverance: Reflections of people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis participating in biomedical research. A qualitative focus group study". Health Expectations. 0 (0). doi:10.1111/hex.12857. ISSN 1369-7625. PMID 30632248.
  19. Nacul, Luis; de Barros, Barbara; Kingdon, Caroline C.; Cliff, Jacqueline M.; Clark, Taane G.; Mudie, Kathleen; Dockrell, Hazel M.; Lacerda, Eliana M. (April 10, 2019). "Evidence of Clinical Pathology Abnormalities in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) from an Analytic Cross-Sectional Study". Diagnostics. 9 (2): 41. doi:10.3390/diagnostics9020041. ISSN 2075-4418.
  20. Cliff, Jacqueline M.; King, Elizabeth C.; Lee, Ji-Sook; Sepúlveda, Nuno; Wolf, Asia-Sophia; Kingdon, Caroline; Bowman, Erinna; Dockrell, Hazel M.; Nacul, Luis; Lacerda, Eliana; Riley, Eleanor (April 16, 2019). "Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)". Frontiers in Immunology. 10. doi:10.3389/fimmu.2019.00796. ISSN 1664-3224.
  21. Rodrigues, Lucas S; Nali, Luiz H da Silva; Leal, Cibele O D; Sabino, Ester C; Lacerda, Eliana M; Kingdon, Caroline C; Nacul, Luis; Romano, Camila M (July 5, 2019). "HERV-K and HERV-W transcriptional activity in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome". bioRxiv. doi:10.1101/693465.
  22. Sepúlveda, Nuno; Carneiro, Jorge; Eliana M. Lacerda, Eliana M.; Nacul, Luis C. (October 2019). "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a hyper-regulated immune system driven by an interplay between regulatory T cells and chronic human herpesvirus infections". Frontiers in Immunology. doi:10.3389/fimmu.2019.02684.
  23. Lacerda, Eliana M.; Geraghty, Keith; Kingdon, Caroline C.; Palla, Luigi; Nacul, Luis (December 2019). "A logistic regression analysis of risk factors in ME/CFS pathogenesis". BMC Neurology. 19 (1): 275. doi:10.1186/s12883-019-1468-2. ISSN 1471-2377.
  24. Friedberg, Fred; Sunnquist, Madison; Nacul, Luis (March 1, 2020). "Rethinking the Standard of Care for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Journal of General Internal Medicine. 35 (3): 906–909. doi:10.1007/s11606-019-05375-y. ISSN 1525-1497. PMC 7080939. PMID 31637650.
  25. Nacul, Luis; O'Boyle, Shennae; Nacul, Flavio E.; Mudie, Kathleen; Kingdon, Caroline C.; Cliff, Jacqueline M.; Clark, Taane G.; Dockrell, Hazel M.; Lacerda, Eliana M. (September 17, 2019). "How Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) Progresses: A Framework for Research and the Prevention, Treatment, and Rehabilitation in ME/CFS". Preprints. doi:10.20944/preprints201909.0188.v1.
  26. Estévez-López, Fernando; Mudie, Kathleen; Wang-Steverding, Xia; Bakken, Inger Johanne; Ivanovs, Andrejs; Castro-Marrero, Jesús; Nacul, Luis; Alegre, Jose; Zalewski, Paweł; Słomko, Joanna; Bolle Strand, Elin; Pheby, Derek; Shikova, Evelina; Lorusso, Lorenzo; Capelli, Enrica; Sekulic, Slobodan; Scheibenbogen, Carmen; Sepúlveda, Nuno; Murovska, Modra; Lacerda, Eliana (May 2020). "Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology". Journal of Clinical Medicine. 9 (5): 1557. doi:10.3390/jcm9051557.
  27. Malato, João; Sotzny, Franziska; Bauer, Sandra; Freitag, Helma; Fonseca, André; Grabowska, Anna D; Graça, Luís; Cordeiro, Clara; Nacul, Luís; Lacerda, Eliana M; Castro-Marrero, Jesus; Scheibenbogen, Carmen; Westermeier, Francisco; Sepúlveda, Nuno (March 24, 2021). "The SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: analysis of high-throughput epigenetic and gene expression studies". medRxiv. doi:10.1101/2021.03.23.21254175. PMID 33791744.

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

National Institutes of Health (NIH) - A set of biomedical research institutes operated by the U.S. government, under the auspices of the Department of Health and Human Services.

BMJ The BMJ (previously the British Medical Journal) is a weekly peer-reviewed medical journal.

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.