Vitamin C
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
 | This article is a stub. The talk page may contain suggestions. |
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin found particularly in citrus fruits and green vegetables.
Function[edit | edit source]
High levels of vitamin C are found in the pituitary, adrenal gland, pancreas, liver, spleen and brain.[1]
Mast cell activation disorder[edit | edit source]
Numerous studies have found Vitamin C to be inversely correlated with histamine and that the administration of Vitamin C reduces blood histamine levels.[2][3][4] It does this potentially through several mechanisms: by inhibiting mast cell production; by increasing diamine oxidase (an enzyme that breaks down histamine); by inhibiting mast cell degranulation (and the release of histamine in the first place),[5] and by inhibiting histidine decarboxylase (the enzyme that forms histamine).[6]
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- ↑ "Vitamin neurotoxicity". Mol Neurobiology.
- ↑ Clemetson, C. A. (April 1980), "Histamine and ascorbic acid in human blood", The Journal of Nutrition, 110 (4): 662–668, ISSN 0022-3166, PMID 7365537
- ↑ Johnston, C. S.; Martin, L. J.; Cai, X. (April 1992), "Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis", Journal of the American College of Nutrition, 11 (2): 172–176, ISSN 0731-5724, PMID 1578094
- ↑ Johnston, CS (December 1996). "Vitamin C depletion is associated with alterations in blood histamine and plasma free carnitine in adults". J Am Coll Nutr.
- ↑ Mio, M (1999). "Ultraviolet B (UVB) light-induced histamine release from rat peritoneal mast cells and its augmentation by certain phenothiazine compounds". Immunopharmacology.
- ↑ Molderings, Gerhard (2016). "Pharmacological treatment options for mast cell activation disease". Naunyn Schmiedebergs Arch Pharmacol.
