Peripheral blood mononuclear cell

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Peripheral Blood Mononuclear Cells or PBMCs are types of white blood cells with a round nuclei, including lymphocytes, macrophages and monocytes, but not granulocytes (polymorphonuclear leucocytes like neutophils, eosinophils and basophils).[1][2]

PBMCs are less dense than granulocytes, and less dense than red blood cells.[3]

See also[edit | edit source]

Notable studies[edit | edit source]

  • 2001, G-Actin Cleavage Parallels 2-5A-Dependent RNase L Cleavage in Peripheral Blood Mononuclear Cells—Relevance to a Possible Serum-Based Screening Test for Dysregulations in the 2-5A Pathway[4] (Abstract)
  • 2017, Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients[5] (Full Text)
  • 2018, A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy[6](Abstract)
  • 2018, A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)[7] (Full text)

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ Oellerich, Michael; Dasgupta, Amitava (2015). "Chapter 9 - Intracellular concentrations of immunosuppressants". Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring. Elsevier. p. 200. ISBN 9780128011331.
  2. ↑ Brooker, Chris (2008). Churchill Livingstone Medical Dictionary E-Book. Elsevier Health Sciences. pp. 206, 369. ISBN 9780080982458.
  3. ↑ Bittersohl, Heike; Steimer, Werner (2016), Intracellular concentrations of immunosuppressants, Elsevier, pp. 199–226, doi:10.1016/b978-0-12-800885-0.00009-6, ISBN 9780128008850
  4. ↑ Roelens, Simon; Herst, C. Vincent; D'Haese, Anne; De Smet, Karen; Frémont, Marc; De Meirleir, Kenny; Englebienne, Patrick (January 1, 2001). "G-Actin Cleavage Parallels 2-5A-Dependent RNase L Cleavage in Peripheral Blood Mononuclear Cells—Relevance to a Possible Serum-Based Screening Test for Dysregulations in the 2-5A Pathway". Journal of Chronic Fatigue Syndrome. 8 (3–4): 63–82. doi:10.1300/J092v08n03_07. ISSN 1057-3321.
  5. ↑ Nguyen, T.; Johnston, S.; Chacko, A.; Gibson, D.; Cepon, J.; Smith, D.; Staines, D.; Marshall-Gradisnik, S. (2017), "Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients", Asian Pac J Allergy Immunol, 35 (2): 75-81, doi:10.12932/AP0771
  6. ↑ Xu, Jiabao; Potter, Michelle; Tomas, Cara; Elson, Jo; Morten, Karl; Poulton, Joanna; Wang, Ning; Jin, Hanqing; Hou, Zhaoxu (2018). "A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy". The Analyst. doi:10.1039/C8AN01437J. ISSN 0003-2654.
  7. ↑ Davis, R.W.; Wilhelmy, J.; Nemat-Gorgani, M.; Kashi, A.; Esfandyarpour, R. (April 25, 2019). "A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)". Proceedings of the National Academy of Sciences. 116 (21): 10250–10257. doi:10.1073/pnas.1901274116. ISSN 0027-8424. PMID 31036648.

serum The clear yellowish fluid that remains from blood plasma after clotting factors have been removed by clot formation. (Blood plasma is simply blood that has had its blood cells removed.)

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