Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Studies controlling for deconditioning or other confounders
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
Some major potential confounding factors inherent in research on ME/CFS patients include physical deconditioning and social isolation. This page lists studies which attempt to control for potential confounders, for example by including a second control group of severely deconditioned people in studies observing biological abnormalities. It is important to note that deconditioning and social isolation are consequences and not causes of ME/CFS.<ref>{{Cite journal|title=Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Essentials of Diagnosis and Management|date=November 2021|url=https://doi.org/10.1016/j.mayocp.2021.07.004|journal=Mayo Clinic Proceedings|volume=96|issue=11|pages=2861β2878|last=Bateman|first=Lucinda|last2=Bested|first2=Alison C.|last3=Bonilla|first3=Hector F.|last4=Chheda|first4=Bela V.|last5=Chu|first5=Lily|last6=Curtin|first6=Jennifer M.|last7=Dempsey|first7=Tania T.|last8=Dimmock|first8=Mary E.|last9=Dowell|first9=Theresa G.|last10=Felsenstein|first10=Donna|last11=Kaufman|first11=David L.|doi=10.1016/j.mayocp.2021.07.004|issn=0025-6196}}</ref> == Studies == * Understanding Muscle Dysfunction in Chronic Fatigue Syndrome, 2016<ref>{{Cite journal|title=Understanding Muscle Dysfunction in Chronic Fatigue Syndrome|date=2016|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779819/|journal=Journal of Aging Research|volume=2016|pages=2497348|last=Rutherford|first=Gina|last2=Manning|first2=Philip|last3=Newton|first3=Julia L.|doi=10.1155/2016/2497348|pmc=4779819|pmid=26998359|issn=2090-2204}}</ref> ** This paper describes two studies that tested muscle acidosis after repeat exercise, one in ME/CFS<ref>{{Cite journal|title=Effects of HβOβ on electrical membrane properties of skeletal myotubes|date=Jan 15, 2011|url=https://pubmed.ncbi.nlm.nih.gov/21109001/|journal=Free Radical Biology & Medicine|volume=50|issue=2|pages=337β344|last=Luin|first=Elisa|last2=Giniatullin|first2=Rashid|last3=Sciancalepore|first3=Marina|doi=10.1016/j.freeradbiomed.2010.11.015|pmid=21109001|issn=1873-4596}}</ref> and the other in primary biliary cirrhosis (PBC)<ref name=":0">{{Cite journal|title=Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in primary biliary cirrhosis|date=Jul 2010|url=https://pubmed.ncbi.nlm.nih.gov/20447719/|journal=Journal of Hepatology|volume=53|issue=1|pages=155β161|last=Hollingsworth|first=Kieren G.|last2=Newton|first2=Julia L.|last3=Robinson|first3=Lisa|last4=Taylor|first4=Roy|last5=Blamire|first5=Andrew M.|last6=Jones|first6=David E. J.|doi=10.1016/j.jhep.2010.02.022|pmid=20447719|issn=1600-0641}}</ref>. They say that PBC causes a similar level of fatigue to ME/CFS.<ref>{{Cite journal|title=Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in primary biliary cirrhosis|date=Jul 2010|url=https://pubmed.ncbi.nlm.nih.gov/20447719/|journal=Journal of Hepatology|volume=53|issue=1|pages=155β161|last=Hollingsworth|first=Kieren G.|last2=Newton|first2=Julia L.|last3=Robinson|first3=Lisa|last4=Taylor|first4=Roy|last5=Blamire|first5=Andrew M.|last6=Jones|first6=David E. J.|doi=10.1016/j.jhep.2010.02.022|pmid=20447719|issn=1600-0641}}</ref> The studies showed that both groups showed abnormally high intramuscular acidosis after exercise. But in contrast, the level of acidosis decreases with repeat exercise in PBC, but not in ME/CFS. * [[Buspirone challenge test]] ** When buspirone is given to people with ME/CFS, the resulting increase in prolactin is greater than in healthy controls. Studies have also shown a similar abnormally high response in other conditions, such as dyspepsia and social anxiety disorder. A similar response to healthy controls was seen in people with depression or mania. The opposite response, lower prolactin, was seen in those with schizophrenia. *Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise, Giloteaux et al, Jan 2024<ref>{{Cite journal |last=Giloteaux |first=Ludovic |last2=Glass |first2=Katherine A. |last3=Germain |first3=Arnaud |last4=Franconi |first4=Carl J. |last5=Zhang |first5=Sheng |last6=Hanson |first6=Maureen R. |date=Jan 2024 |title=Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise |url=https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev2.12403 |journal=Journal of Extracellular Vesicles |language=en |volume=13 |issue=1 |doi=10.1002/jev2.12403 |issn=2001-3078 |pmc=PMC10764978 |pmid=38173127}}</ref> == References == {{Reflist}}
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Templates used on this page:
Template:Cite journal
(
edit
)
Template:Main other
(
edit
)
Template:Reflist
(
edit
)
Module:Check for unknown parameters
(
edit
)
Module:Citation/CS1
(
edit
)
Module:Citation/CS1/COinS
(
edit
)
Module:Citation/CS1/Configuration
(
edit
)
Module:Citation/CS1/Date validation
(
edit
)
Module:Citation/CS1/Identifiers
(
edit
)
Module:Citation/CS1/Utilities
(
edit
)
Module:Citation/CS1/Whitelist
(
edit
)
Module:No globals
(
edit
)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs