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Autoimmune disease
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'''Autoimmune diseases''' arise from an abnormal immune response of the body against substances and tissues normally present in the body. ==Types of autoimmune diseases== Autoimmune diseases can be localized, which means affecting only specific tissues or organs, or systematic, making affecting many tissues or organs.<ref name="ImmunologyMar2017" /> ===Localized autoimmune disease=== Examples include: * [[Crohn's disease]] * [[diabetes#type_1|Type 1 diabetes]] * [[Graves' disease]], which is one of the most common causes of thyroiditis<ref name="ImmunologyMar2017" /> ===Systemic autoimmune diseases=== Examples include: * [[Multiple sclerosis]] (MS) * [[Rheumatoid arthritis]] * Scleroderma * [[Systemic lupus erythematosus]] (Lupus)<ref name="ImmunologyMar2017" >{{Cite web |url = https://www.immunology.org/sites/default/files/autoimmunity-briefing.pdf | last = British Society for Immunology | date = Mar 2016| title = Autoimmunity|access-date = 2019-07-12}}</ref> == Autoimmune hypothesis in ME and CFS == [[File:MECFS comorbid autoimmune.jpg|alt=Shows fibromyalgia 30-77% overlap, Hashimoto's thyroiditis 17-20%, POTS 11-40% overlap and family history of autoimmune conditions 18-41% overlap.|thumb|Autoimmune conditions in people with ME/CFS. Source: Sotzny et al (2018), [[EUROMENE]] project.]] Many people with ME/CFS also have autoimmune conditions such as [[Fibromyalgia]] or [[Hashimoto's thyroiditis]], or have a family history of autoimmune diseases.<ref name="Sotzny, 2018" /> [[Postural orthostatic tachycardia syndrome|POTS]], or postural orthostatic tachycardia syndrome, can be initiated or maintained by autoantibodies as well, and POTS is common in people with ME. A number of different immune system abnormalities have been found in some patients with ME/CFS.<ref name="Sotzny, 2018" /> {{Main article|Autoimmune hypothesis}} ME/CFS is being investigated to determine if it is caused by Autoimmunity in some patients. ==Notable studies == *2018, [http://10.1016/j.autrev.2018.01.009 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease]<ref name="Sotzny, 2018">{{citation | last = Sotzny | first1 = Franziska | author-link1 = Franziska Sotzny | last2 = Blanco | first2 = Julià | author-link2 = Julià Blanco | last3 = Capelli | first3 = Enrica | author-link3 = Enrica Capelli | last4 = Castro-Marrero | first4 = Jesús | author-link4 = Jesús Castro-Marrero | last5 = Steiner | first5 = Sophie | author-link5 = Sophie Steiner | last6 = Murovska | first6 = Modra | author-link6 = Modra Murovska | last7 = Scheibenbogen | first7 = Carmen | author-link8 = Carmen Scheibenbogen | title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease | journal = Autoimmunity Reviews | volume = 17 | issue = 6 | page = 601-609 | date = 2018 | doi = 10.1016/j.autrev.2018.01.009 }}</ref> ==See also== * [[Autoimmune hypothesis]] * [[Innate immune system]] ==Learn more == *[https://www.immunology.org/sites/default/files/autoimmunity-briefing.pdf Autoimmunity]- British Society for Immunology == References == {{Reflist}} [[Category:Diagnoses]] [[Category:Immunology]] [[Category:Autoimmune diseases and disorders]]
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