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Caloric restriction
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==Risks and side effects== Risks in people with ME/CFS are unclear due to a lack of clinical trials.<ref name="Craig2015"/> Navarro et al. report that hypocaloric diets that restrict calorie intake too severely, for example to 1,000kcal or less per day, are dangerous rather than beneficial.<ref name="Navarro2013">https://pubmed.ncbi.nlm.nih.gov/24010747/</ref> Rapid weight loss caused by inadequate food take in a known cause of [[fatigue]] and can cause harmful metabolic changes, including [[muscle atrophy|rapid reduction in muscle]].<ref name="Navarro2013"/> People with ME/CFS are known to have nutritional deficiencies caused by the disease rather than by diet, so it is not clear how a long-term hypocaloric diet may need to be adapted to avoid [[malnutrition]].<ref name="ICC2011primer"/><ref name="canadianconsensus-CCC">{{Citation | last1 = Carruthers | first1 = Bruce M. | author-link1 = Bruce Carruthers | last2 = Jain | first2 = Anil Kumar | author-link2 = Anil Kumar Jain | last3 = De Meirleir | first3 = Kenny L. | author-link3 = Kenny De Meirleir | last4 = Peterson | first4 = Daniel L. | author-link4 = Daniel Peterson | last5 = Klimas | first5 = Nancy G. | author-link5 = Nancy Klimas | last6 = Lerner | first6 = A. Martin | author-link6 = Martin Lerner | last7 = Bested | first7 = Alison C. | author-link8 = Alison Bested | last8 = Flor-Henry | first8 = Pierre | author-link8 = Pierre Flor-Henry | last9 = Joshi | first9 = Pradip | author-link9 = Pradip Joshi | last10 = Powles | first10 = AC Peter | author-link10 = A C Peter Powles | last11 = Sherkey | first11 = Jeffrey A. | author-link11 = Jeffrey Sherkey | last12 = van de Sande | first12 = Marjorie I. | author-link12 = Marjorie van de Sande | title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols| journal = Journal of Chronic Fatigue Syndrome | volume = 11 | issue = 2 | pages = 7-115 | date = 2003 | pmid = | doi = 10.1300/J092v11n01_02| url = http://www.investinme.org/Documents/PDFdocuments/CanadianDefinitionME-CFS.pdf}}</ref>
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