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Adenocorticotropic hormone
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=== ME/CFS === As ACTH is a major hormone in the HPA axis, ACTH may be related to [[myalgic encephalomyelitis]] (ME) because HPA axis dysregulation has been associated with ME. However, studies in this area have found a wide range in results; a 2007 review of HPA function in ME found that about half of all studies indicated HPA hypofunction in ME, whereas the other half of the studies did not find differences in ACTH within HPA function between ME and controls.<ref>{{Cite journal | last = Van Den Eede | first = Filip | last2 = Moorkens | first2 = Greta | last3 = Van Houdenhove | first3 = Boudewijn | author-link = | last4 = Cosyns | first4 = Paul | last5 = Claes | first5 = Stephan J. | date = 2007 | title=Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome | url =https://www.karger.com/Article/Abstract/104468 | journal = Neuropsychobiology|language=en | volume = 55 | issue = 2 | pages = 112β120|doi=10.1159/000104468|issn=0302-282X|quote= | author-link2 = | author-link3 = Boudewijn Van Houdenhove | author-link4 = | author-link5 = |via=}}</ref> This could be partly explained by how some patients report higher levels of ACTH and cortisol early in the disease, with depleted/lower levels as the disease progresses.
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