Transforming growth factor beta

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Transforming growth factor beta (TGF-β ) is a cytokine secreted by many types of cells including macrophages.

TGF-β is disturbed in Marfan's syndrome and Loeys–Dietz syndrome.

It activates fibroblast proliferation[1] and stimulates fibroblasts to release connective tissue growth factor (CTGF).[2]

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References[edit | edit source]

  1. ↑ Strutz, Frank; Zeisberg, Michael; Renziehausen, Anja; Raschke, Birgit; Becker, Volker; Van Kooten, Cees; Müller, Gerhard A. (February 1, 2001). "TGF-β1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)". Kidney International. 59 (2): 579–592. doi:10.1046/j.1523-1755.2001.059002579.x. ISSN 0085-2538.
  2. ↑ Grotendorst, Gary R. (September 1, 1997). "Connective tissue growth factor: a mediator of TGF-β action on fibroblasts". Cytokine & Growth Factor Reviews. 8 (3): 171–179. doi:10.1016/S1359-6101(97)00010-5. ISSN 1359-6101.

β β / Β. Greek letter beta (a symbol used in science), equivalent to "b".

β β / Β. Greek letter beta (a symbol used in science), equivalent to "b".

cytokine any class of immunoregulatory proteins secreted by cells, especially immune cells. Cytokines are small proteins important in cell signaling that modulate the immune system. (Learn more: me-pedia.org)

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