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ME/CFS Priority Setting Partnership
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==Top 10+ Priorities == The following research priorities were identified and published in May 2022: :1. What is the [[Myalgic_encephalomyelitis#Pathophysiology|biological mechanism]] that causes [[post-exertional malaise]] (symptoms caused or made worse by physical, mental or emotional effort, which can be delayed) in people with ME/CFS? How is this best treated and managed? :2. Which existing drugs used to treat other conditions might be useful for treating ME/CFS, such as [[low dose naltrexone]], or drugs used to treat [[Postural orthostatic tachycardia syndrome|Postural Orthostatic Tachycardia Syndrome]] (POTS)? :3. How can an accurate and reliable [[diagnostic biomarker|diagnostic test]] be developed for ME/CFS? :4. Is ME/CFS caused by a faulty immune system? Is ME/CFS an [[autoimmune disease|autoimmune condition]]? :5. Are there [[different types of ME/CFS]] linked to [[:Category:Triggers and risk factors|different causes]] and/or how [[severe and very severe ME|severe]] it becomes? Do different types of ME/CFS need different treatments and/or have [[Prognosis_for_myalgic_encephalomyelitis_and_chronic_fatigue_syndrome#Predictors_of_outcome|different chances of recovery]]? :6. Why do some people develop ME/CFS following an [[infection]]? Is there a link with [[Long COVID|long-COVID]]? :7. What causes the [[central nervous system|central]] and [[peripheral nervous system]]s (brain, spinal cord and nerves in the body) to malfunction in people with ME/CFS? Could this understanding lead to new treatments? :8. Is there a [[Genetics of chronic fatigue syndrome|genetic link to ME/CFS]]? If yes, how does this affect the risk of ME/CFS in families? Could this lead to new treatments? :9. What causes ME/CFS to become [[severe and very severe ME|severe]]? :10. How are [[mitochondria]], responsible for the body's energy production, affected in ME/CFS? Could this understanding lead to new treatments? ::10+. Does poor delivery or use of [[oxygen]] within the body cause ME/CFS symptoms? If so, how is this best treated?<ref name="Top10">{{Cite web|url=https://psp-me.co.uk/explore-the-top-10 | title = ME/CFS Top 10+ Priorities|website=ME/CFS Priority Setting Partnership | date = May 2022|access-date=May 16, 2022}}</ref>
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