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Intimidation and bullying of PACE trial critics
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=== The PACE trial === The [[PACE trial]] was a large randomized trial to test the efficacy and safety of several behavioral interventions including [[cognitive behavioral therapy]] (CBT) and [[graded exercise therapy]] (GET) in [[ME/CFS]] patients.<ref name="PACEprotocol" /> Since the start of the trial in 2003, PACE has been criticized on [[research bias in ME/CFS|methodological ]]grounds.<ref>Margaret Williams. [http://www.margaretwilliams.me/2004/critical-considerations.pdf Critical considerations.] November 1, 2004</ref><ref name="PACEprotocol">{{Cite web | url = https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-7-6 | title = Protocol for the PACE trial: A randomised controlled trial of adaptive pacing, cognitive behaviour therapy, and graded exercise as supplements to standardised specialist medical care versus standardised specialist medical care alone for patients with the chronic fatigue syndrome/myalgic encephalomyelitis or encephalopathy | last = Walwyn | first = Rebecca | last2 = DeCesare | first2 = Julia C. | date = Dec 2007 | website = BMC Neurology|language=en|doi=10.1186/1471-2377-7-6/comments|access-date=2019-02-21 | last3 = Chalder | first3 = Trudie | last4 = Sharpe | first4 = Michael C. | last5 = White | first5 = PeterD.}}</ref> Criticism includes invalid [[selection criteria]],<ref>{{Cite journal | last = Jason | first = Leonard A. | date = Aug 2017 | title = The PACE trial missteps on pacing and patient selection | url =https://www.ncbi.nlm.nih.gov/pubmed/28805518|journal=Journal of Health Psychology|volume=22|issue=9|pages=1141โ1145|doi=10.1177/1359105317695801|issn=1461-7277|pmid=28805518}}</ref><ref name="Tuller2015">{{Cite web | url = http://www.virology.ws/2015/10/21/trial-by-error-i/ | title = TRIAL BY ERROR: The Troubling Case of the PACE Chronic Fatigue Syndrome Study | last = Tuller | first = David | authorlink = David Tuller | date = Oct 21, 2015 | website = [[Virology blog]]|archive-url=|archive-date=|url-status=|access-date=2019-02-21}}</ref><ref>{{Cite journal | last = Goudsmit | first = Ellen | last2 = Howes | first2 = Sandra | date = Aug 2017 | title = Bias, misleading information and lack of respect for alternative views have distorted perceptions of myalgic encephalomyelitis/chronic fatigue syndrome and its treatment | url = https://www.ncbi.nlm.nih.gov/pubmed/28805527|journal=Journal of Health Psychology|volume=22|issue=9|pages=1159โ1167|doi=10.1177/1359105317707216|issn=1461-7277|pmid=28805527}}</ref> [http://methods.sagepub.com/reference/encyc-of-research-design/n44.xml ceiling effects] in [[pubmed:26528658/|outcome measurements]],<ref name="Tuller2015" /><ref>{{Cite web | url = https://www.statnews.com/2016/09/21/chronic-fatigue-syndrome-pace-trial/ | title = How bad science misled chronic fatigue syndrome patients | date = 2016-09-21 | website = STAT|language=en-US|access-date=2019-02-21}}</ref> violation of the declaration of Helsinki regarding Good Clinical Practice,<ref name="Tuller2015" /><ref name="Tuller-PACE">{{Cite web | url = https://www.meaction.net/2015/10/21/david-tuller-tears-apart-pace-trial/ | title = David Tuller Tears Apart PACE Trial | last = Anderssen | first = Alex | authorlink = | date = 2015-10-21 | website = #MEAction|language=en-US|archive-url=|archive-date=|url-status=|access-date=2019-02-21}}</ref> and deviation from the [[trial protocol|trial's protocol]] without providing [[Sensitivity analysis|sensitivity analyses]].<ref name="Wilshire2018">{{Cite journal | last = Wilshire | first = Carolyn E. | last2 = Kindlon | first2 = Tom | last3 = Courtney | first3 = Robert | last4 = Matthees | first4 = Alem | last5 = Tuller | first5 = David | last6 = Geraghty | first6 = Keith | last7 = Levin | first7 = Bruce | date = 2018-03-22 | title = Rethinking the treatment of chronic fatigue syndromeโa reanalysis and evaluation of findings from a recent major trial of graded exercise and CBT | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863477/|journal=BMC Psychology|volume=6|doi=10.1186/s40359-018-0218-3|issn=2050-7283|pmc=5863477|pmid=29562932}}</ref><ref>{{Cite web | url = https://peterkempblog.wordpress.com/2016/09/10/pace-trial-participants-were-they-exploited/ | title = PACE Trial Participants โ were they exploited? | last = peterkempblog | date = 2016-09-10 | website = peterkempblog|language=en|access-date=2019-02-21}}</ref>
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