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Diagnostic biomarker
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==Others== Other biomarkers being researched: *Dr. [[Kevin Conley]] and Dr. [[David Maughan]], University of Washington, Seattle, Washington, US are studying the abnormal response of the [[Muscle metabolite|muscle metabolites]], [[NADP]]+/[[NADPH]], as a molecular marker in ME/CFS patients before and after fatiguing exercise by using advanced, non-invasive [[magnetic resonance spectroscopy]] (MRS).<ref>{{Cite web | url = https://solvecfs.org/promising-non-invasive-diagnostic-testing-project-seeks-to-detect-mecfs/ | title = Non-Invasive Diagnostic Test Project Seeks to Detect ME/CFS | date = 2017-01-13 | website = Solve ME/CFS Initiative|language=en-US|access-date=2020-02-04}}</ref> *Dr. [[Isabel Barao]] hypothesizes that [[FcR]] (a protein found on the surface of certain cells) dysfunction in [[immune cells]] is a risk factor for the development of ME/CFS. The [[Bateman Horne Center]], the National Cancer Institute (NCI) at [[NIH]], and Roche Pharmaceuticals, are examining [[Polymorphism|polymorphisms]] and mutations of [[FcgR]]s in NK cells of ME/CFS patients and their associations to [[antibody-dependent cell-mediated cytotoxicity]] (ADCC) capability and disease pathology.<ref>{{Cite web | url = https://batemanhornecenter.org/uncovering-biomarkers-fcg-receptors/ | title = Uncovering Biomarkers - Fcg Receptors in ME/CFS | date = 2016-04-15 | website = Bateman Horne Center|language=en-US|access-date=2020-02-04}}</ref> *the presence of salivary [[Human herpesvirus 6]] (HHV6) and [[Human herpesvirus 7]] (HHV7) biomarkers to distinguish physiological fatigue from pathological fatigue<ref name="Aoki, 2016" /> *[[visible and near-infrared]] (Vis-NIR) spectroscopy of patients' thumbs are being explored in Japan as a non-invasive test for CFS<ref name="Sakudo, 2016" /><ref name="Sakudo, 2012" />
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