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Cell danger response hypothesis
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== Highlights == [http://www.sciencedirect.com/science/article/pii/S1567724913002390 Metabolic features of the cell danger response] paper by [[Robert Naviaux]] includes the following bullet points:<ref>[http://www.sciencedirect.com/science/article/pii/S1567724913002390 Metabolic features of the cell danger response. Elsevier - Robert K. Naviaux]</ref> *The Cell Danger Response (CDR) is defined in terms of an ancient metabolic response to threat. *The CDR encompasses inflammation, innate immunity, oxidative stress, and the ER stress response. *The CDR is maintained by extracellular nucleotide (purinergic) signaling. *Abnormal persistence of the CDR lies at the heart of many chronic diseases. *Antipurinergic therapy (APT) has proven effective in many chronic disorders in animal models.
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