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[[File:Alan Light.png|right|Source: University of Utah Faculty page]] '''Alan R. Light''', Ph.D., is a Research Professor of Anesthesiology, Neurobiology and Anatomy at the Interdepartmental Program in Neuroscience at the University of Utah. He studies the neurobiology of pain and fatigue enhancement caused by injury and in [[chronic fatigue syndrome|Chronic Fatigue Syndrome]] and [[Fibromyalgia]].<ref name="profile">http://neuroscience.med.utah.edu/Faculty/Light.html</ref> Professor Light and his wife. Dr. [[Kathleen Light]], are known for their work on post-exertional gene expression after exercise. Dr. Light is a member of the Working Group which offers their expertise and resources to the [[ME/CFS Collaborative Research Center at Stanford University]].<ref>{{Cite web | url = https://bos.etapestry.com/prod/viewEmailAsPage.do?erRef=773.0.423082047&databaseId=OMF&mailingId=34274682&jobRef=773.0.506425459&key=b6b9237b3ebd1e462a5d11dbc5c4dae&personaRef=773.0.423082048&memberId=1348639685 | title = OMF grants $1.2M to Ramp Up Collaborative Research Center at Stanford University | website = bos.etapestry.com | access-date = 2021-10-24}}</ref> ==International Consensus Criteria== Dr. Light is one of the authors of the 2011 case definition, [[International Consensus Criteria]].<ref name="ICC">{{Cite journal | last = Carruthers | first = Bruce M. | author-link = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | author-link2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | author-link3 = Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | author-link4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | author-link5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | author-link6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link8 = Donald Staines | last8 = Powles | first8 = A.C. Peter | author-link8 = A C Peter Powles | last9 = Speight | first9 = Nigel | author-link9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | author-link10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | author-link11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | author-link12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | author-link14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | author-link15 = John Chia | last16 = Darragh | first16 = Austin | author-link16 = Austin Darragh | last17 = Jo | first17 = Daehyun | author-link17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria | url = https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x | journal = Journal of Internal Medicine|language=en | volume = 270 | issue = 4 | pages = 327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> ==Awards== *Javits Neuroscience Investigator Award (a seven-year research grant) from the [[National Institutes of Health]] for his research on descending control of pain.<ref>{{Cite web | url = https://faculty.utah.edu/u0320393-ALAN_R_LIGHT/research/index.hml | title = ALAN R LIGHT - Research - Faculty Profile| website= The University of Utah | access-date = 2021-10-24}}</ref> *2010 - Won Second Place in Oral Presentations at the 2010 Annual Meeting of the American Society Anesthesiologists for '''A novel approach to studying the sensory pathways involved in the perception of fatigue'''<ref name="Pollak, 2010" /> ==Education== *B.A. 1972, Hamilton College *Ph.D. 1977, SUNY at Upstate Medical Center *Postdoctoral Fellow 1977-1979, UNC-Chapel Hill ==Talks and interviews== *Aug 12, 2017, [[Community Symposium on the Molecular Basis of ME/CFS - 2017]]: Speech title - [https://www.youtube.com/watch?v=xDQL7v4XlRU&index=7&list=PLl4AfLZNZEQOQG8vr4Rn_YY1E1cbFIu45 Gene variants, mitochondria & autoimmunity in ME/CFS] *[https://www.youtube.com/watch?v=S3CmUJyVBbQ Alan Light - Segment 3: Update on Dr. Light's Recent CFS and FM Research] (Feb 22, 2016) *[https://www.youtube.com/watch?v=oyjuWwuKmFA Alan Light - Segment 2: Detailed Explanation of Dr. Light's CFS and FM Research] (Feb 22, 2016) *[https://www.youtube.com/watch?v=ZZyXUL7CPks&feature=youtu.be Alan Light - Segment 1: Why Research Chronic Fatigue Syndrome and Fibromyalgia?] (Feb 22, 2016) *[https://www.youtube.com/watch?v=TeTrCE4Iwo0 Partnerships to Accelerate Biomarker and Mechanisms Discovery in ME/CFS and Fibromyalgia - Alan Light, PhD] (5 Dec 2015) *[https://www.youtube.com/watch?v=a6NqOYdBRrg Solve ME/CFS Initiative Webinar "New Developments in ME/CFS Research" - Alan Light, PhD] (Oct 15, 2015)] ===Short web seminars Science to patients / Wetenschap voor patienten=== English speech, with Dutch subtitles *2015, [https://youtu.be/OAv3vhCL2pU 58. Fatigue / Vermoeidheid - Prof. Alan Light] *2015, [https://youtu.be/ghUtM44yfm0 59. Genes & Gene-Expression/ Genen en gen-expressie - Prof. Alan Light] *2015, [https://youtu.be/6G4hJDlk-mk 60. Gene expression markers of ME/cfs / Gen-expressie markers van ME/cvs - Prof. Alan Light] *2015, [https://youtu.be/HkMBIkNGCqA 61. Fatigue and Pain in ME/cfs / Vermoeidheid en pijn bij ME/cvs - Prof. Alan Light] *2015, [https://youtu.be/6-RMY1nSPBQ 62. ME/cfs and exclusive Conditions / ME/cvs en uitsluitingsaandoeningen - Prof. Alan Light] *2015, [https://youtu.be/McH2GJobOuk 63. Effects of ME/cfs on the Brain / Effecten van ME/cvs op de hersenen - Prof. Alan Light] *2015, [https://youtu.be/xzxQ-j25jAg 64. ME/cfs, immune system, cell functioning / ME/cvs, immuunsysteem en cel functioneren - Prof. Alan Light] ==Books== *2010, Chapter 11: Myalgia and Fatigue—Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes In: ''Translational Pain Research – From Mouse to Man''<ref name="ch11">{{Cite book |chapter-url=https://www.ncbi.nlm.nih.gov/books/NBK57253/ | last = Light | first = A.R. | author-link = Alan Light | last2 = Vierck | first2 =C.J. | last3 = Light | first3 = K.C. | author-link3 = Kathleen Light | date = 2010|chapter =Myalgia and Fatigue—Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes | title = Translational Pain Research – From Mouse to Man|editor-first = Lawrence|editor-last = Kruger |editor-first2 = Alan|editor-last2 = Light|editor-link2 = Alan Light|publisher =CRC Press/Taylor & Francis|location =Boca Raton (FL)|isbn=978-1-4398-1209-9 | url = https://www.ncbi.nlm.nih.gov/books/NBK57269/}}</ref> [https://www.ncbi.nlm.nih.gov/books/NBK57253/ (Full Text)] ==Notable studies related to ME/CFS== *2017, Neural Consequences of Post-Exertion Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome<ref name="Cook, 2017">{{Cite journal | last1 = Cook | first1 = Dane B. | author-link1 = Dane Cook | last2 = Light | first2 = Alan R. | author-link2 = Alan Light | last3 = Light | first3 = Kathleen C. | author-link3 = Kathleen Light | last4 = Broderick | first4 = Gordon | author-link4 = Gordon Broderick | last5 = Shields | first5 = Morgan R. | author-link5 = | last6 = Dougherty | first6 = Ryan J. | author-link6 = | last7 = Meyer | first7 = Jacob D. | author-link7 = | last8 = VanRiper | first8 = Stephanie | author-link8 = | last9 = Stegner | first9 = Aaron J. | author-link9 = | last10= Ellingson | first10 = Laura D. | author-link10 =| last11= Vernon | first11 = Suzanne D. | author-link11 = Suzanne Vernon | title = Neural Consequences of Post-Exertion Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome| journal = Brain, Behavior, and Immunity | volume = 62 | issue = | page = 87-99 | url = https://www.sciencedirect.com/science/article/pii/S088915911730051X | pmid = 28216087 | date = 2017 | doi = 10.1016/j.bbi.2017.02.009}}</ref> [http://www.sciencedirect.com/science/article/pii/S088915911730051X (Full Text)] *2017, Symptom variability following acute exercise in myalgic encephalomyelitis/chronic fatigue syndrome: a perspective on measuring post-exertion malaise<ref name="Lindheimer, 2017">{{Cite journal | last1 = Lindheimer | first1 = Jacob B. | author-link1 = | last2 = Meyer | first2 = Jacob D. | author-link2 = | last3 = Stegner | first3 = Aaron J. | author-link3 = | last4 = Dougherty | first4 = Ryan J. | author-link4 = | last5 = Van Riper | first5 = Stephanie M. | author-link5 = | last6 = Shields | first6 = Morgan | author-link6 = | last7 = Reisner | first7 = Amanda | author-link7 = | last8 = Shukla | first8 = Sanjay K. | author-link8 = | last9 = Light | first9 = Alan R. | author-link9 = Alan Light | last10= Yale | first10 = Steven | author-link10 = | last11= Cook | first11 = Dane B. | author-link11 = Dane Cook| title = Symptom variability following acute exercise in myalgic encephalomyelitis/chronic fatigue syndrome: a perspective on measuring post-exertion malaise| journal = Fatigue: Biomedicine, Health & Behavior | volume = 5 | issue = 2 | page = 69-88| date = 2017| url = https://doi.org/10.1080%2F21641846.2017.1321166 | pmid= | doi = 10.1080/21641846.2017.1321166}}</ref> [https://doi.org/10.1080/21641846.2017.1321166 (Abstract)] *2016, Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample<ref name="Iacob, 2016">{{Cite journal | last1 = Iacob | first1 = E | author-link1 = | last2 = Light | first2 = AR | author-link2 = Alan Light | last3 = Donaldson | first3 = GW | author-link3 =| last4 = Okifuji | first4 = A | author-link4 = | last5 = Hughen | first5 = RW | author-link5 = | last6 = White | first6 = AT | author-link6 = | last7 = Light | first7 = K | author-link8 = Kathleen Light| title = Gene expression factor analysis to differentiate pathways linked to fibromyalgia, chronic fatigue syndrome, and depression in a diverse patient sample| journal = Arthritis Care and Research | volume = 68 | issue = 1 | page = 132-40 | url = https://onlinelibrary.wiley.com/doi/epdf/10.1002/acr.22639 | pmc = PMC4684820 | date = 2016 | pmid = 26097208 | doi = 10.1002/acr.22639}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684820/ (Full Text)] *2013, Post-Exertion Malaise in Chronic Fatigue Syndrome: Symptoms and Gene Expression<ref name="Meyer, 2013">{{Cite journal | last1 = Meyer | first1 = Jacob D | author-link1 = | last2 = Light | first2 = Alan R | author-link2 = Alan Light | last3 = Shukla | first3 = Sanjay K | author-link3 = | last4 = Clevidence | first4 = Derek | author-link4 = | last5 = Yale | first5 = Steven | author-link5 = | last6 = Stegner | first6 = Aaron J | author-link6 = | last7 = Cook | first7 = Dane C | author-link8 = Dane Cook| title = Post-Exertion Malaise in Chronic Fatigue Syndrome: Symptoms and Gene Expression| journal = Fatigue: Biomedicine, Health, & Behavior | volume = 1 | issue = 4 | page = 190-209 | date = 2013| url = https://www.tandfonline.com/doi/full/10.1080/21641846.2013.838444 |pmid= | doi = 10.1080/21641846.2013.838444}}</ref> [https://www.researchgate.net/profile/Jacob-Meyer-5/publication/258165434_Post-exertion_malaise_in_chronic_fatigue_syndrome_Symptoms_and_gene_expression/links/55269a910cf2f6e651697982/Post-exertion-malaise-in-chronic-fatigue-syndrome-Symptoms-and-gene-expression.pdf (Full text)] *2013, Differing [[leukocyte]] gene expression profiles associated with fatigue in patients with prostate cancer versus chronic fatigue syndrome<refname="Light2013Prostate">{{Cite journal | last1 = Light | first1 = K.C. | author-link = Kathleen Light | last2 = Agarwal | first2 = N. | last3 = Iacob | first3 = E. | last4 = White | first4 = A.T. | author-link4 = Andrea White | last5 = Kinney | first5 = A.Y. | last6 = Vanhaitsma | first6 = T.A. | last7 = Aizad | first7 = H. | last8 = Hughen | first8 = R.W. | last9 = Bateman | first9 = L. | author-link9 = Lucinda Bateman | last10 = Light | first10 = A.R. | date = 2013 | title = Differing leukocyte gene expression profiles associated with fatigue in patients with prostate cancer versus chronic fatigue syndrome | journal = Psychoneuroendocrinology | volume = 38 | issue = 12 | pages = 2983-2995 | doi = 10.1016/j.psyneuen.2013.08.008 | pmid = 24054763 | pmc = PMC3848711 | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848711 }}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848711/ (Full Text)] *2012, Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome<ref name="Light2012Stress">{{Cite journal | last1 = Light | first1 = KC | author-link = Kathleen Light | last2 = White | first2 = AT | author-link2 = Andrea White | last3 = Tadler | first3 =S | last4 = Iacob | first4 = E| last5 = Light | first5 = Alan R | author-link5 = Alan Light | url= https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200121/ | title = Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome | journal = Pain Research and Treatment | date = 2012 | page = 427869 | pmc = PMC3200121 |doi= 10.1155/2012/427869}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200121/ (Full text)] *2012, Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with [[multiple sclerosis]], and healthy controls<ref name="White, 2012">{{Cite journal | last1 = White | first1 = AT | author-link1 = Andrea White | last2 = Light | first2 = AR | author-link2 = Alan Light | last3 = Hughen | first3 = RW | author-link3 = | last4 = Vanhaitsma | first4 = TA | author-link4 = | last5 = Light | first5 = KC | author-link5 = Kathleen Light| title = Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls| journal = Psychosomatic Medicine | volume = 74 | issue = 1 | page = 46-54 | date = 2012| pmid= | pmc = PMC3256093| url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256093/| doi = 10.1097/PSY.0b013e31824152ed}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256093/ (Full text)] *2012, Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome<ref name="Light, 2012">{{Cite journal | last1 = Light | first1 = Alan R | author-link1 = Alan Light | last2 = Bateman | first2 = Lucinda | author-link2 = Lucinda Bateman | last3 = Jo | first3 = Daehyun | author-link3 = Daehyun Jo | last4 = Hughen | first4 = Ronald W | author-link4 = | last5 = Vanhaitsma | first5 = Timothy A | author-link5 = | last6 = White | first6 = AT | author-link6 = Andrea White | last7 = Light | first7 = Kathleen | author-link8 = Kathleen Light| title = Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome| journal = Journal of Internal Medicine | volume = 271 | issue = 1 | page = 64-81 | date = 2012| pmid= | pmc = PMC3175315 | doi= 10.1111/j.1365-2796.2011.02405.x | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175315/ }}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175315/ (Full Text)] *2011, Evidence for a heritable predisposition to Chronic Fatigue Syndrome<ref name="Albright, 2011">{{Cite journal | last1 = Albright | first1 = Frederick | author-link1 = | last2 = Light | first2 = Kathleen | author-link2 = Kathleen Light | last3 = Light | first3 = Alan | author-link3 = Alan Light | last4 = Bateman | first4 = Lucinda | author-link4 = Lucinda Bateman | last5 = Cannon-Albright | first5 = Lisa A | author-link5 = | title = Evidence for a heritable predisposition to Chronic Fatigue Syndrome| journal = BMC Neurology | volume = 11 | issue = | page = 62 | url = https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-11-62 | pmc = PMC3128000 | pmid = 21619629 | date = 2011| doi= 10.1186/1471-2377-11-62}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128000/ (Full Text)] *2011, Absence of XMRV retrovirus and other murine leukemia virus-related viruses in patients with chronic fatigue syndrome<ref name="Shin2011">{{Cite journal | last = Shin | first = Clifford H. | last2 = Bateman | first2 = Lucinda | author-link2 = Lucinda Bateman | last3 = Schlaberg | first3 = Robert | last4 = Bunker | first4 = Ashley M. | last5 = Leonard | first5 = Christopher J. | last6 = Hughen | first6 = Ronald W. | last7 = Light | first7 = Alan R. | author-link7 = Alan Light | last8 = Light | first8 = Kathleen C | author-link8 = Kathleen Light | last9 = Singh | first9 = Ila R. | date = Jul 2011 | title = Absence of XMRV retrovirus and other murine leukemia virus-related viruses in patients with chronic fatigue syndrome | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126563/ | journal = Journal of Virology | volume = 85 | issue = 14 | pages = 7195-202|doi=10.1128/JVI.00693-11|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126563/ (Full Text)] *2010, A novel approach to studying the sensory pathways involved in the perception of fatigue<ref name="Pollak, 2010">{{Cite journal | last1 = Pollak | first1 = Kelly | author-link1 = | last2 = Jo | first2 = Daehyun | author-link2 = Daehyun Jo | last3 = Vanhaitsma | first3 = Timothy A | author-link3 = | last4 = Hughen | first4 = Ron W | author-link4 = | last5 = Light | first5 = Alan R | author-link5 = Alan Light| title = A novel approach to studying the sensory pathways involved in the perception of fatigue.| journal = Journal of Critical Care | volume = 25 | issue = 4 | page = e18 | date = 2010 | pmid = | doi = 10.1016/j.jcrc.2010.08.023 | url = https://www.jccjournal.org/article/S0883-9441(10)00264-9/abstract }}</ref> [https://www.jccjournal.org/article/S0883-9441(10)00264-9/abstract (Abstract)] *2010, Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome<ref name="Light2010Flare">{{Cite journal | last1 = White | first1 = A.T. | author-link1 = Andrea White | last2 = Light | first2 = A.R. | author-link2 = Alan Light | last3 = Hughen | first3 = R.W. | author-link3 = | last4 = Bateman | first4 = L. | author-link4 = Lucinda Bateman | last5 = Martins | first5 = T.B. | author-link5 = | last6 = Hill | first6 = H.R. | author-link6 = | last7 = Light | first7 = K.C. | author-link8 = Kathleen Light | date = 2010 | title = Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome | journal = Psychophysiology | volume = 47 | issue =4 | pages =615-24 |doi = 10.1111./j.1469-8986.2010.00978.x | pmc = PMC4378647 | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378647/ }}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378647/ (Full Text)] *2009, Moderate Exercise Increases Expression for Sensory, Adrenergic, and Immune Genes in Chronic Fatigue Syndrome Patients But Not in Normal Subjects<ref name="Light2009">{{Cite journal | last1 = Light | first1 = A.R. | author-link = Alan Light | last2 = White | first2 = A.T. | author-link2 = Andrea White | last3 = Hughen | first3 =R.W. | last4 = Light | first4 = K.C. | author-link4 = Kathleen Light | date = 2009 | title = Moderate Exercise Increases Expression for Sensory, Adrenergic, and Immune Genes in Chronic Fatigue Syndrome Patients But Not in Normal Subjects | journal = The Journal of Pain | volume = 10 | pages = 1099-1112 | pmc = PMC2757484 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757484/}}</ref> [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757484/ (Full Text)] ==Open Letter to The Lancet== Two [[open letter to the Lancet | open letters to the editor of The Lancet journal]] urged the editor to commission a fully independent review of the [[PACE trial]], which it had published in 2011. In 2016, Dr. Light, along with 41 colleagues in the [[ME/CFS]] field, signed the second letter<ref name="openletter">[http://www.virology.ws/2016/02/10/open-letter-lancet-again/ An open letter to The Lancet, again - Virology blog]</ref> ==News and media coverage== *2014, [http://www.deseretnews.com/article/865603384/Sufferers-of-chronic-fatigue-fibromyalgia-have-hope-in-new-diagnostic-tool.html Sufferers of chronic fatigue, fibromyalgia have hope in new diagnostic tool] ==Online presence== *[http://neuroscience.med.utah.edu/Faculty/Light.html University of Utah - Alan Light] *[http://www.ncbi.nlm.nih.gov/pubmed/?term=Light%20AR%5BAuthor%5D&cauthor=true&cauthor_uid=26097208 PubMed] ==Learn more== ==See also== *[[Exercise]] *[[Two-day cardiopulmonary exercise test]] ==References== {{Reflist}} [[Category:Researchers]] [[Category:US researchers]] [[Category:Psychological paradigm critics]] [[Category:PACE trial critics]]
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