Doctor Sarah Myhill is a British doctor running her own specialist M.E. clinic in Knighton, Powys LD7 1SL, Wales, United Kingdom. Her web site is an extensive resource of articles and information based on her treatment of patients. The website runs to 920 webpages and has had over 6 million individual visits.
Dr Myhill's view is that the disease is characterised by a cellular metabolic mitochondrial dysfunction and has published several studies. Dr Myhill has treated in excess of 10,000 CFS/ME sufferers over her 30 year career.
Dr Myhill explains her philosophy of medicine here
Dr Myhill has been the subject of complaints to the General Medical Council. A recent Freedom of Information Act request confirmed that Dr Myhill is the most investigated doctor in the history of the GMC. She has been subject to in excess of 30 investigations in the last 15 years. None of the complainants against Dr Myhill were patients. All complaints against her have been dropped and she practises with a full unrestricted medical licence.
- 2013, Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (FULL TEXT)
Abstract: "We report on an audit of 138 ME/CFS patients who attended a private practice and took the ATP Profile biomedical test. The results revealed that all of these patients had measureable mitochondrial dysfunction. A basic treatment regime, based on 1) eating the evolutionary correct stone-age diet, 2) ensuring optimum hours of good quality sleep, 3) taking a standard package of nutritional supplements, and 4) getting the right balance between work and rest, was recommended for all patients. Additions to the basic regime were tailored for each patient according to the results of the ATP Profile and additional nutritional tests and clues from the clinical history. Mitochondrial function is typically impaired in two ways: substrate or co-factor deficiency, and inhibition by chemicals, exogenous or endogenous. For the former, additional nutrients are recommended where there is a deficiency, and for the latter, improvement of anti-oxidant status and selective chelation therapy or far-infrared saunas are appropriate. We show case histories of nine patients who have taken the ATP Profile on three or four occasions, and a before-and-after treatment summary of the 34 patients who have had at least two ATP Profile tests separated by some months. Finally, we summarize the results for the 30 patients who followed all aspects of the treatment regime and compare them with the 4 patients who were lax on two or more aspects of the treatment regime. All patients who followed the treatment regime improved in mitochondrial function by on average a factor of 4."
- 2012, Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (FULL TEXT)
Abstract: "The objectives of this study are to test the hypothesis that the fatigue and accompanying symptoms of Chronic Myalgic Encephalomyelitis/Fatigue Syndrome are in part due to defects in energy provision at the cellular level, and to understand the pathophysiology of the defects so that effective medical intervention can be implemented. We performed an audit of 138 patients (ages 18-65) diagnosed with ME/CFS and attending a private practice. The patients and 53 normal, healthy controls had the ATP Profile test carried out on neutrophils from a 3-ml venous blood sample. This test yields 6 numerical factors that describe the availability of ATP and the efficiency of oxidative phosphorylation in mitochondria. Other biomedical measurements, including the concentration of cell-free DNA in plasma, were made. The results of the audit are compared with the controls and a previous cohort of 61 patients. We find that all patients tested have measureable mitochondrial dysfunction which correlates with the severity of the illness. The patients divide into two main groups differentiated by how cellular metabolism attempts to compensate for the dysfunction. Comparisons with exercise studies suggest that the dysfunction in neutrophils also occurs in other cells. This is confirmed by the cell-free DNA measurements which indicate levels of tissue damage up to 3.5 times the normal reference range. The major immediate causes of the dysfunction are lack of essential substrates and partial blocking of the translocator protein sites in mitochondria. The ATP Profile is a valuable diagnostic tool for the clinical management of ME/CFS."
- 2009, Chronic fatigue syndrome and mitochondrial dysfunction (FULL TEXT)
Abstract: "This study aims to improve the health of patients suffering from chronic fatigue syndrome (CFS) by interventions based on the biochemistry of the illness, specifically the function of mitochondria in producing ATP (adenosine triphosphate), the energy currency for all body functions, and recycling ADP (adenosine diphosphate) to replenish the ATP supply as needed. Patients attending a private medical practice specializing in CFS were diagnosed using the Centers for Disease Control criteria. In consultation with each patient, an integer on the Bell Ability Scale was assigned, and a blood sample was taken for the “ATP profile” test, designed for CFS and other fatigue conditions. Each test produced 5 numerical factors which describe the availability of ATP in neutrophils, the fraction complexed with magnesium, the efficiency of oxidative phosphorylation, and the transfer efficiencies of ADP into the mitochondria and ATP into the cytosolwhere the energy is used. With the consent of each of 71 patients and 53 normal, healthy controls the 5 factors have been collated and compared with the Bell Ability Scale. The individual numerical factors show that patients have different combinations of biochemical lesions. When the factors are combined, a remarkable correlation is observed between the degree of mitochondrial dysfunction and the severity of illness (P<0.001). Only 1 of the 71 patients overlaps the normal region. The “ATP profile” test is a powerful diagnostic tool and can differentiate patients who have fatigue and other symptoms as a result of energy wastage by stress and psychological factors from those who have insufficient energy due to cellular respiration dysfunction. The individual factors indicate which remedial actions, in the form of dietary supplements, drugs and detoxification, are most likely to be of benefit, and what further tests should be carried out."
- 2014, Diagnosis and Treatment of Chronic Fatigue Syndrome: It's Mitochondria, Not Hypochondria by Sarah Myhill. Edited by, and with a chapter by Craig Robinson.
Talks and interviews
- 2016, OMEGA AGM Seminar 2016
- 2015, Biocare Summer 2015 Conference
- 2007, Speaker at the 2nd Invest in ME International ME Conference on Treatments and Diagnosis – A GP’s Perspective DVD available
- More talks and interviews can be found on Dr Myhill’s YouTube channel as above
- Dr Myhill's Wiki style Website
- Support Dr Sarah Myhill public Facebook group
- Support for followers of Dr Myhill's protocol closed Facebook group
- Supporters of Dr Sarah Myhill Facebook page
- Dr Myhill's official Twitter feed
- Dr Myhill's official YouTube channel
- 2012, "Booth, Myhill, McLaren-Howard Comment on ME/CFS Mitochondrial Dysfunction Paper" by Norman E. Booth, Sarah Myhill, John McLaren-Howard for ProHealth
Dr Myhill has a checklist that she recommends all CFS/ME sufferers follow - this can be found at this website address:
- Myhill, S; Booth, NE; McLaren-Howard, J (2013), "Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - a clinical audit", International Journal of Clinical Experimental Medicine, 6 (1): 1–15, PMID 23236553
- Booth, NE; Myhill, S; McLaren-Howard, J (15 Jun 2012), "Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)", International Journal of Clinical Experimental Medicine, 5 (3): 208–220, PMID 22837795
- Myhill, S; Booth, NE; McLaren-Howard, J (15 Jan 2009), "Chronic fatigue syndrome and mitochondrial dysfunction", International Journal of Clinical Experimental Medicine, 2 (1): 1–16, PMID 19436827
- CFS - The Central Cause: Mitochondrial Failure
- Dr. Myhill on BBC News (video), 29 Apr 2010