Robert Naviaux

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Source: gordonmedical.com

Robert K. Naviaux, MD, PhD, is a Professor in Residence at the University of California, San Diego, California, USA. His work "has focused on the role of mitochondrial DNA replication, copy number regulation, DNA damage, and nucleotide signaling in development, aging, healing and regeneration in mitochondrial mechanisms of disease and development."[1] He was invited to join the Open Medicine Foundation's research team in 2016, following a announcement that the ME/CFS Severely Ill, Big Data Study had a significant result in the area of mitochondria.[2]

Dr. Naviaux directs the Robert Naviaux Laboratory at University of California, San Diego (UCSD) whose work is "divided into two groups: 1) Mitochondrial Mechanisms of Disease and Development, and 2) Evolutionary Systems Biology and Marine Metagenomics."[3] He is founder and co-director of the Mitochondrial and Metabolic Disease Center at UCSD, the co-founder and a former president of the Mitochondrial Medicine Society, as well as, a founding associate editor of the journal, Mitochondrion.[4]

Dr. Naviaux "discovered the cause and created the diagnostic test for Alpers syndrome, a mitochondrial disease... [and] is the director of the first FDA-approved clinical trial to study suramin [an antiparasitic drug] as a treatment for autism."[5][6]

Currently, Dr. Naviaux is using his mitochondria expertise, especially in metabolomics, to look for a biomarker and potential treatment for ME/CFS.[7]

In May 2016, a study was launched, led by Dr. Naviaux and Dr. Ronald Davis, in collaboration with Dr. Eric Gordon, Dr. Paul Cheney, and the Stanford Genome Technology Center in order "to validate earlier findings of a possible diagnostic signature for ME/CFS by measuring metabolites and to evaluate the contribution of genetics to the variation in observed metabolic signatures in this disease." The initial phase, with a total of 90 participants, has been completed and suggests "the mitochondria is in hypometabolism due to a chronic cell danger response state in ME/CFS patients."[8]

Education[edit | edit source]

  • 1994-1997 - Fellowship (Biochemical Genetics, mtDNA Replication), University of California, San Diego Medical Center, San Diego, CA
  • 1990-1994 - Postdoctorate (Retrovirology, Gene Therapy), The Salk Institute, La Jolla, CA
  • 1986-1990 - Internship and Residency, Internal Medicine, American Board of Internal Medicine (ABIM), Clinical Investigator Pathway, University of California, Davis
  • 1986, 1989 - M.D., Ph.D. (Genetics, Virology), Indiana University School of Medicine, Indianapolis, IN
  • 1981 - M.S. (Zoology), Indiana University, Bloomington, IN
  • 1979 - B.S. (Biological Sciences), University of California, Davis, CA
  • 1977-1978 - Undergraduate (Biochemistry), Georg August Universität, Göttingen, Germany

Notable studies[edit | edit source]

  • 2017, A robust, single-injection method for targeted, broad-spectrum plasma metabolomics[9] (Full Text)
  • 13 Sep 2016, Metabolic features of chronic fatigue syndrome[10] (Full Text)
  • 7 Feb 2017, Reply to Roerink et al.: Metabolomics of chronic fatigue syndrome[11]
  • 15 Nov 2016, Reply to Vogt et al.: Metabolomics and chronic fatigue syndrome[12]

Awards and Honors[edit | edit source]

  • 2008, Hailey’s Wish Foundation - Hailey’s Hero Award, For Outstanding Research and Clinical Care of children with mitochondrial disease
  • 2007, Thomson ESI - Science Citation Index “Fast Moving Front Article”
  • 2007, United Mitochondrial Disease Foundation Mitochondrial Medicine - Best Abstract Award
  • 2002, Honored in a non-fiction book entitled, Anna’s Friends — Lessons Learned from a Short and Beautiful Life

Talks and interviews[edit | edit source]

Keynote Speech: The metabolism of the cell danger response, healing, and ME/CFS
(with Spanish subtitles)

Articles[edit | edit source]

Online presence[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. http://profiles.ucsd.edu/robert.naviaux
  2. http://www.openmedicinefoundation.org/2016/02/10/welcome-dr-naviaux-to-our-team/
  3. http://med.ucsd.edu/divisions/med-genetics/research/Pages/Naviaux-Lab.aspx
  4. http://www.openmedicinefoundation.org/2016/02/10/welcome-dr-naviaux-to-our-team/
  5. http://www.openmedicinefoundation.org/2016/02/10/welcome-dr-naviaux-to-our-team/
  6. Clinical Trial Launched to Assess Safety and Efficacy of Autism Drug Treatment - Newsroom By: Scott LaFee
  7. http://www.healthrising.org/forums/threads/the-mitochondria-man-gets-his-money-and-the-uk-goes-mega-me-cfs-research-moving-forward.4360/
  8. http://www.openmedicinefoundation.org/expanded-mecfs-metabolomics-study/
  9. Li, Kefeng; Naviaux, Jane C.; Bright, A. Taylor; Wang, Lin; Naviaux, Robert K (2017), "A robust, single-injection method for targeted, broad-spectrum plasma metabolomics", Metabolomics, 13 (122), doi:10.1007/s11306-017-1264-1 
  10. Naviaux, Robert K; Naviaux, Jane C.; Li, Kefeng; Bright, A. Taylor; Alaynick, William A.; Wang, Lin; Baxter, Asha; Nathan, Neil; Anderson, Wayne; Gordon, Eric (13 Sep 2016), "Metabolic features of chronic fatigue syndrome", PNAS, 113 (37), doi:10.1073/pnas.1607571113 
  11. Naviaux, Robert K; Gordon, Eric (7 Feb 2017), "Reply to Roerink et al.: Metabolomics of chronic fatigue syndrome.", Proc Natl Acad Sci USA, 114 (6): E911-E912, doi:10.1073/pnas.1618984114 
  12. Naviaux, Robert K; Naviaux, Jane C.; Li, Kefeng; Bright, A. Taylor; Alaynick, William A.; Wang, Lin; Baxter, Asha; Nathan, Neil; Anderson, Wayne; Gordon, Eric (15 Nov 2016), "Reply to Vogt et al.: Metabolomics and chronic fatigue syndrome", Proc Natl Acad Sci USA, 113 (46): E7142–E7143, doi:10.1073/pnas.1616261113 
  13. Naviaux, Robert K. (May 2014), "Metabolic features of the cell danger response", Mitochondrion, 16: 7–17, doi:10.1016/j.mito.2013.08.006, PMID 23981537 


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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history