GABA: Difference between revisions
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{{Cleanup/Citations needed | {{Cleanup/Citations needed|date=Dec 2019|reason=No references}} | ||
'''Gamma aminobutyric acid''' (GABA), is a [[neurotransmitter]] made from the [[:Category:Amino acids|amino acid]] [[glutamate]]. GABA is the chief inhibiting, or calming [[neurotransmitter]] in the [[brain]], functioning as a brake on the neural circuitry during [[stress]]. Low GABA levels are associated with [[restlessness]], [[anxiety]], [[insomnia]] and a | '''Gamma aminobutyric acid''' (GABA), is a [[neurotransmitter]] made from the [[:Category:Amino acids|amino acid]] [[glutamate]]. GABA is the chief inhibiting, or calming [[neurotransmitter]] in the [[brain]], functioning as a brake on the neural circuitry during [[stress]]. Low GABA levels are associated with [[restlessness]], [[anxiety]], [[insomnia]] and a low mood/[[depression]]. GABA works to balance [[glutamate]] (excitatory) in the brain. GABA is the brake pedal on a car while glutamate is the gas pedal.{{citation needed}} | ||
Supplements to support GABA | Supplements to support GABA and glutamate are: | ||
amino acids GABA | *amino acids GABA | ||
*[[theanine|L-theanine]] | |||
*[[N-acetyl-cysteine]] (NAC) | |||
*[[vitamin B6]] | |||
*[[vitamin D]] | |||
*[[magnesium]] | |||
*[[zinc]] | |||
*[[Omega 3 fatty acid]], and | |||
*[[inositol]]{{citation needed|date=September 2020}} | |||
==Notable studies== | ==Notable studies== | ||
*2005, [https://www.ncbi.nlm.nih.gov/pubmed/15757488 GABA and glutamate systems as therapeutic targets in depression and mood disorders] | *2005, [https://www.ncbi.nlm.nih.gov/pubmed/15757488 GABA and glutamate systems as therapeutic targets in depression and mood disorders]<ref>{{Cite journal|last=Kendell|first=Steven F.|author-link=|last2=Krystal|first2=John H.|author-link2=|last3=Sanacora|first3=Gerrard|author-link3=|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=February 2005|title=GABA and glutamate systems as therapeutic targets in depression and mood disorders|url=https://www.ncbi.nlm.nih.gov/pubmed/15757488|journal=Expert Opinion on Therapeutic Targets|volume=9|issue=1|pages=153–168|doi=10.1517/14728222.9.1.153|issn=1744-7631|pmc=|pmid=15757488|access-date=|quote=|via=}}</ref> | ||
*2005, [https://www.ncbi.nlm.nih.gov/pubmed/16400244 Beyond monoamines: glutamatergic function in mood disorders] | *2005, [https://www.ncbi.nlm.nih.gov/pubmed/16400244 Beyond monoamines: glutamatergic function in mood disorders]<ref>{{Cite journal|last=Kugaya|first=Akira|author-link=|last2=Sanacora|first2=Gerard|author-link2=|last3=|first3=|author-link3=|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=Oct 2005|title=Beyond monoamines: glutamatergic function in mood disorders|url=https://www.ncbi.nlm.nih.gov/pubmed/16400244|journal=CNS spectrums|volume=10|issue=10|pages=808–819|doi=10.1017/s1092852900010403|issn=1092-8529|pmc=|pmid=16400244|access-date=|quote=|via=}}</ref> | ||
*2006, [https://www.ncbi.nlm.nih.gov/pubmed/16971751 Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans] | *2006, [https://www.ncbi.nlm.nih.gov/pubmed/16971751 Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans]<ref name="pmid16971751">{{Cite journal|last=Abdou|first=Adham M.|last2=Higashiguchi|first2=S.|last3=Horie|first3=K.|last4=Kim|first4=Mujo|last5=Hatta|first5=H.|last6=Yokogoshi|first6=H.|date=2006|title=Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans|url=https://pubmed.ncbi.nlm.nih.gov/16971751/|journal=BioFactors (Oxford, England)|volume=26|issue=3|pages=201–208|doi=10.1002/biof.5520260305|issn=0951-6433|pmid=16971751}}</ref> | ||
*2007, Thorne Research, Inc: Gamma-Aminobutyric Acid (GABA). Alternative Medicine Review, 2007; 12(3) | *2007, Thorne Research, Inc: Gamma-Aminobutyric Acid (GABA). Alternative Medicine Review, 2007; 12(3) | ||
==See also== | ==See also== | ||
*[[:Category:Neurotransmitters]] | *[[Glutamate]] | ||
*[[:Category:Neurotransmitters|Neurotransmitters (category)]] | |||
==Learn more == | ==Learn more == | ||
Revision as of 00:21, September 28, 2020
 | This article needs cleanup to meet MEpedia's guidelines. The reason given is: This page needs additional references or sources for verification - multiple references need to be added. (Dec 2019) |
Gamma aminobutyric acid (GABA), is a neurotransmitter made from the amino acid glutamate. GABA is the chief inhibiting, or calming neurotransmitter in the brain, functioning as a brake on the neural circuitry during stress. Low GABA levels are associated with restlessness, anxiety, insomnia and a low mood/depression. GABA works to balance glutamate (excitatory) in the brain. GABA is the brake pedal on a car while glutamate is the gas pedal.[citation needed]
Supplements to support GABA and glutamate are:
- amino acids GABA
- L-theanine
- N-acetyl-cysteine (NAC)
- vitamin B6
- vitamin D
- magnesium
- zinc
- Omega 3 fatty acid, and
- inositol[citation needed]
Notable studies[edit | edit source]
- 2005, GABA and glutamate systems as therapeutic targets in depression and mood disorders[1]
- 2005, Beyond monoamines: glutamatergic function in mood disorders[2]
- 2006, Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans[3]
- 2007, Thorne Research, Inc: Gamma-Aminobutyric Acid (GABA). Alternative Medicine Review, 2007; 12(3)
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- ↑ Kendell, Steven F.; Krystal, John H.; Sanacora, Gerrard (February 2005). "GABA and glutamate systems as therapeutic targets in depression and mood disorders". Expert Opinion on Therapeutic Targets. 9 (1): 153–168. doi:10.1517/14728222.9.1.153. ISSN 1744-7631. PMID 15757488.
- ↑ Kugaya, Akira; Sanacora, Gerard (October 2005). "Beyond monoamines: glutamatergic function in mood disorders". CNS spectrums. 10 (10): 808–819. doi:10.1017/s1092852900010403. ISSN 1092-8529. PMID 16400244.
- ↑ Abdou, Adham M.; Higashiguchi, S.; Horie, K.; Kim, Mujo; Hatta, H.; Yokogoshi, H. (2006). "Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans". BioFactors (Oxford, England). 26 (3): 201–208. doi:10.1002/biof.5520260305. ISSN 0951-6433. PMID 16971751.
