Muscle fasciculations

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Muscle fasciculations or muscle twitches are small, local, involuntary muscle contractions in skeletal muscles. Superficial muscle fasciculations are visible to the eye. Deeper muscle fasciculations are detected by electromyography (EMG) testing.[1] They result from an involuntary firing of a single motor neuron (nerve cell) and all its innervated muscle fibers.[2]

Muscle fasciculations can occur in healthy people especially in the eyelid muscles, and are considered benign, however, when fasciculations are accompanied by muscle weakness or atrophy, these fasciculations may indicate a neurological dysfunction.[3]

Prevalence[edit | edit source]

  • In a 2001 Belgian study, 58.5% of patients meeting the Fukuda criteria and 64.1% of patients meeting the Holmes criteria, in a cohort of 2073 CFS patients, reported muscle fasciculations.[4]

Symptom recognition[edit | edit source]

The Canadian Consensus Criteria lists muscle fasciculations as a symptom of ME/CFS under the section Neurological/Cognitive Manifestations.[5]

Notable studies[edit | edit source]

Possible causes[edit | edit source]

Potential treatments[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. https://en.wikipedia.org/wiki/Fasciculation
  2. Killian, J.M.. (2010). Electromyography. 428-435. doi:10.1016/B978-0-323-05712-7.00026-X.
  3. Steven McGee (2018), Chapter 61 – Examination of the Motor System: Approach to Weakness (print) 
  4. De Becker, P; McGregor, N; De Meirleir, K (Sep 2001), "A definition-based analysis of symptoms in a large cohort of patients with chronic fatigue syndrome.", Journal of Internal Medicine, 250 (3): 234-240, PMID 11555128 
  5. Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip; Powles, A C Peter; Sherkey, Jeffrey A.; van de Sande, Marjorie I. (2003), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols", Journal of Chronic Fatigue Syndrome, 11 (2): 7-115, doi:10.1300/J092v11n01_02 


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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history