Byron Hyde

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Dr. Bryon Hyde is a family practice physician in Ottawa, Canada, who has dedicated his practice solely to ME/CFS since 1984. In 1988, he founded the Nightingale Research Foundation, which is committed to exploring and understanding Myalgic Encephalomyelitis and Chronic Fatigue Syndrome (M.E. and CFS) and fibromyalgia-type illnesses.

Notable studies[edit]

  • 2003, Clinical Improvement in Chronic Fatigue Syndrome Is Associated with Enhanced Natural Killer Cell-Mediated Cytotoxicity: The Results of a Pilot Study with Isoprinosine®
    "Abstract - Chronic fatigue syndrome is associated with systemic and cognitive symptoms and with several immune abnormalities. The clinical impact of Isoprinosine® was evaluated in sixteen CFS patients, followed for 28 weeks in a single-blind, placebo controlled trial. Patients were also monitored for various immune parameters. Improvement based on clinical staging was observed in six of ten treated patients (60%). Clinically improved patients showed significantly enhanced natural killer (NK) cell activity, which correlated with the duration of Isoprinosine treatment (p >0.03). Treatment with Isoprinosine resulted in significantly increased numbers of CD4+ T helper cells (p >0.03). Treatment with Isoprinosine for 12 weeks did not appreciably influence the in vitro production of IFN-y, IL-1oc, IL-10 or IL-12. However, IL-12 was significantly increased at week 28 (p >0.02) in patients who improved after treatment with Isoprinosine. These results suggest that taking Isoprinosine may benefit a subgroup of patients with CFS, and this clinical improvement is associated with enhanced NK cell function and IL-12 levels. Further trials to evaluate the use of Isoprinosine in the treatment of CFS patients are warranted."[1]

Clinic location[edit]

Nightingale Research Foundation
121 Iona Street, Ottawa Ontario K1Y 3M1, Canada
info@nightingale.ca

Talks & interviews[edit]

Books[edit]

Online presence[edit]

Learn more[edit]

See also[edit]

References[edit]

  1. Francisco Diaz-Mitoma, Eva Turgonyi, Ashok Kumar, Wilfred Lim, Louise Larocque & Byron M. Hyde. (2003). Clinical Improvement in Chronic Fatigue Syndrome Is Associated with Enhanced Natural Killer Cell-Mediated Cytotoxicity: The Results of a Pilot Study with Isoprinosine®. Journal of Chronic Fatigue Syndrome, Vol. 11, Iss. 2, pp. 71-95. http://dx.doi.org/10.1300/J092v11n02_06
  2. http://www.investinme.eu/IIMEC2.shtml#agenda
  3. http://www.investinme.eu/IIMEC1.shtml#agenda


The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history