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Peripheral blood mononuclear cell
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{{NeedsImage}} '''Peripheral Blood Mononuclear Cells''' or '''PBMCs''' are types of [[Leucocyte|white blood cells]] with a ''round nuclei'', including [[lymphocyte]]s, [[Macrophage|macrophages]] and [[monocyte]]s, but not [[Granulocyte|granulocytes]] (polymorphonuclear [[Leucocyte|leucocytes]] like [[Neutrophil|neutophils]], [[Eosinophil|eosinophils]] and [[Basophil granulocyte|basophils]]).<ref name="IntracellularCh9">{{Cite book | url =https://books.google.co.uk/books?id=HeTIBAAAQBAJ&pg=PA200&dq=&hl=en | title = Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring | last = Oellerich | first = Michael | last2 = Dasgupta | first2 = Amitava | date = |publisher=Elsevier| year = 2015 |isbn=9780128011331|editor-link=|location=|pages=200|language=en|chapter=Chapter 9 - Intracellular concentrations of immunosuppressants|quote=|editor-last2=|editor-link2=}}</ref><ref>{{Cite book | url =https://books.google.com/books/about/Churchill_Livingstone_Medical_Dictionary.html?id=sj8dKW9xLAYC | title = Churchill Livingstone Medical Dictionary E-Book | last = Brooker | first = Chris | date = 2008|publisher=Elsevier Health Sciences| year = |isbn=9780080982458|editor-link=|location=|pages=206, 369|language=en|chapter=|quote=|editor-last2=|editor-link2=}}</ref> PBMCs are less dense than granulocytes, and less dense than [[Red blood cell|red blood cells]].<ref>{{Citation | last = Bittersohl | first = Heike | last2 = Steimer | first2 = Werner | date = 2016 | title=Intracellular concentrations of immunosuppressants|url=https://linkinghub.elsevier.com/retrieve/pii/B9780128008850000096|language=en|publisher=Elsevier|pages=199–226|doi=10.1016/b978-0-12-800885-0.00009-6|isbn=9780128008850}}</ref> ==See also == * [[Leucocyte|Leucocytes]] (white blood cells) * [[Lymphocyte]] * [[Monocyte]] ==Notable studies == *2001, G-Actin Cleavage Parallels 2-5A-Dependent RNase L Cleavage in Peripheral Blood Mononuclear Cells—Relevance to a Possible Serum-Based Screening Test for Dysregulations in the 2-5A Pathway<ref name="Roelens2001">{{Cite journal | last = Roelens | first = Simon | authorlink = Simon Roelens | last2 = Herst | first2 = C. Vincent | authorlink2 = C Vincent Herst | last3 = D'Haese | first3 = Anne | author-link3 = Anne D'Haese | last4 = De Smet | first4 = Karen | authorlink4 = Karen De Smet | last5 = Frémont | first5 = Marc | authorlink5 = Marc Frémont | last6 = De Meirleir | first6 = Kenny | authorlink6 = Kenny De Meirleir | last7 = Englebienne | first7 = Patrick | authorlink7 = Patrick Englebienne | date = Jan 1, 2001 | title = G-Actin Cleavage Parallels 2-5A-Dependent RNase L Cleavage in Peripheral Blood Mononuclear Cells—Relevance to a Possible Serum-Based Screening Test for Dysregulations in the 2-5A Pathway|url=https://doi.org/10.1300/J092v08n03_07|journal=[[Journal of Chronic Fatigue Syndrome]]|volume=8|issue=3-4 | pages = 63–82|doi=10.1300/J092v08n03_07|issn=1057-3321|quote=|via=}}</ref> [http://dx.doi.org/10.1300/J092v08n03_07 (Abstract)] *2017, Novel characterisation of [[mast cell]] phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients<ref name="Nguyen2017">{{Citation | last1 = Nguyen | first1 = T. | authorlink1 = T Nguyen | last2 = Johnston | first2 = S. | authorlink2 = S Johnston | last3 = Chacko | first3 = A. | authorlink3 = A Chacko | last4 = Gibson | first4 = D. | authorlink4 = D Gibson | last5 = Cepon | first5 = J. | authorlink5 = J Cepon | last6 = Smith | first6 = D. | authorlink6 = D Smith | last7 =Staines | first7 = D. | authorlink7 = Donald Staines | last8 = Marshall-Gradisnik | first8 = S. | authorlink8 = Sonya Marshall-Gradisnik | title = Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients | journal = Asian Pac J Allergy Immunol | volume = 35 | issue = 2 | page = 75-81 | date = 2017 | doi = 10.12932/AP0771 }}</ref> [http://apjai-journal.org/wp-content/uploads/2017/07/75-81-AP0771.pdf (Full Text)] *2018, A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy<ref name="Xu2018">{{Cite journal | last = Xu | first = Jiabao | authorlink = Jiabao Xu | last2 = Potter | first2 = Michelle | authorlink2 = Michelle Potter | last3 = Tomas | first3 = Cara | author-link3 = Cara Tomas | last4 = Elson | first4 = Jo | last5 = Morten | first5 = Karl | authorlink5 = Karl Morten | last6 = Poulton | first6 = Joanna | last7 = Wang | first7 = Ning | last8 = Jin | first8 = Hanqing | last9 = Hou | first9 = Zhaoxu | date = 2018 | title=A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy|url=https://pubs.rsc.org/en/content/articlelanding/2018/an/c8an01437j/|journal=The Analyst|language=en|volume=|pages=|doi=10.1039/C8AN01437J|issn=0003-2654|via=}}</ref>[https://pubs.rsc.org/en/content/articlelanding/2018/an/c8an01437j/ (Abstract)] *2018, A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)<ref name="Davis2019">{{Cite journal | last = Davis | first = R.W. | authorlink = Ronald Davis | last2 = Wilhelmy | first2 = J. | authorlink2 = Julie Wilhelmy | last3 = Nemat-Gorgani | first3 = M. | authorlink3 = Mohsen Nemat-Gorgani | last4 = Kashi | first4 = A. | authorlink4 = Alex Kashi | last5 = Esfandyarpour | first5 = R. | authorlink5 = Rahim Esfandyarpour | date = Apr 25, 2019 | title = A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)|url=https://www.pnas.org/content/early/2019/04/24/1901274116|journal=Proceedings of the National Academy of Sciences|language=en|volume=116|issue=21|pages=10250-10257|doi=10.1073/pnas.1901274116|issn=0027-8424|pmid=31036648|quote=|via=}}</ref> [https://www.pnas.org/content/early/2019/04/24/1901274116 (Full text)] ==Learn more == ==References == [[Category:Biochemistry and cell biology]] {{Reflist}} [[Category:Immunology]]
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