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[[File:Martin Pall.png|right]] '''Martin L. Pall,''' PhD, is a Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University, Pullman, Washington, U.S.A.<ref>{{Cite web|url=https://smb.wsu.edu/faculty-trainees-and-staff/faculty | title = Faculty|website=washington.edu|language=en|access-date=2020-03-02}}</ref> He states that he developed [[Chronic Fatigue Syndrome]] (CFS) from a [[varicella zoster virus]] infection in the later 1990s but has made a full recovery by following a program of avoiding exercise, diet changes, and taking supplements that decrease inflammation.<ref>{{Cite web|url=https://www.prohealth.com/library/live-chat-with-martin-l-pall-phd-july-6-2007-professor-of-biochemistry-explains-mechanisms-of-chronic-fatigue-syndrome-and-fibromyalgia-suggested-protocol-24432 | title = Live Chat with Martin L. Pall, PhD – July 6, 2007: Professor of Biochemistry Explains Mechanisms of Chronic Fatigue Syndrome and Fibromyalgia & Suggested Protocol | last = ProHealth | date = 2007-07-09 | website = Prohealth|language=en-US|access-date=2020-03-02}}</ref> Dr. Pall was one of the authors of the 2011 case definition, the [[International Consensus Criteria]].<ref>{{Cite journal | last = Carruthers | first = Bruce M. | authorlink = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | author-link4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | author-link5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | authorlink6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | authorlink8 = A C Peter Powles | last9 = Speight | first9 = Nigel | authorlink9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | authorlink11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | authorlink12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | author-link14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | author-link15 = John Chia | last16 = Darragh | first16 = Austin | author-link16 = Austin Darragh | last17 = Jo | first17 = Daehyun | author-link17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4 | pages = 327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> ==Education== *1962 - B.A., Johns Hopkins University, Baltimore, MD *1968 - Ph.D., California Institute of Technology, Pasadena, CA ==NO/ONOO-cycle== Dr. Pall developed the [[Nitric oxide hypothesis | Nitric Oxide Cycle Theory]], also, called the NO/ONOO-cycle (pronounced "no-oh-no" cycle) which states that this biochemical cycle causes the inflammation present in [[chronic fatigue syndrome]]/[[myalgic encephalomyelitis]] (CFS/ME), [[multiple chemical sensitivity|Multiple Chemical Sensitivity]] (MCS), [[fibromyalgia]] (FM) and possibly a large number of other chronic inflammatory diseases such as heart disease. "Nitric oxide, acting via its product peroxynitrite, a potent oxidant, acts to initiate a biochemical vicious cycle which is the cause of illness," explains Dr. Pall.<ref>{{Cite web|url=https://www.prohealth.com/library/nitric-oxide-cycle-theory-will-it-explain-cfs-fm-and-other-unexplained-illnesses-qa-with-martin-l-pall-phd-24338 | title = Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other ‘Unexplained’ Illnesses? - Q&A with Martin L. Pall, PhD | date = 2007-06-22 | website = Prohealth|language=en-US|access-date=2020-03-02}}</ref> He believes that certain over-the-counter supplements, such as [[fish oil]], [[CoQ10]], [[vitamin E]], NAC ([[N-acetylcysteine]]), [[magnesium]], and other [[antioxidants]], can help downregulate the oxidation caused by the nitric oxide cycle.<ref>{{Cite web|url=https://www.prohealth.com/library/antioxidant-suggestions-for-down-regulation-of-the-no-onoo-cycle-from-dr-martin-pall-phd-28465 | title = Antioxidant Suggestions For Down-regulation of the NO/ONOO- Cycle from Dr. Martin Pall, PhD | last = Pall|first = Martin L. | date = 2007-06-12 | website = Prohealth|language=en-US|access-date=2020-03-02}}</ref> He believes [[Vitamin B12]] injections can also be a potent nitric oxide scavenger.<ref name=":0">{{Cite web|url=http://www.investinme.org/IIMEC2.shtml | title = Invest in ME Research - IIMEC2 | website = [[Invest in ME Research]]|access-date=2020-03-02}}</ref> ==Book== *2007, ''[[Explaining "Unexplained Illnesses"|Explaining "Unexplained Illnesses": Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome]]''<ref>{{Cite book | title = Explaining "unexplained illnesses" : disease paradigm for chronic fatigue syndrome, multiple chemical sensitivity, fibromyalgia, post-traumatic stress disorder, Gulf War syndrome, and others|isbn=978-0-7890-2388-9|url=https://www.worldcat.org/oclc/73993843 | date = 2007 | publisher=Harrington Park Press | last = Pall|first = Martin L.|oclc=73993843|location=New York}}</ref> ==Articles== *2007, [http://www.prohealth.com//library/showArticle.cfm?libid=12896 ''Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other ‘Unexplained’ Illnesses? - Q&A with Martin L. Pall, PhD''] *2009, [http://www.prohealth.com/library/showarticle.cfm?libid=14467 ''Dr. Pall Debuts Website on 'Tenth-Paradigm' Diseases Including FM, ME/CFS, and MCS''] *2010, [http://www.townsendletter.com/FebMarch2010/cureNO0210.html ''How Can We Cure NO/ONOO− Cycle Diseases? Approaches to Curing Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Fibromyalgia, Multiple Chemical Sensitivity, Gulf War Syndrome and Possibly Many Others" by Martin Pall in Townsend Letter''] ==Talks and interviews== *2007, [http://www.prohealth.com/library/showarticle.cfm?libid=12966 "Live Chat with Martin L. Pall, PhD – July 6, 2007: Professor of Biochemistry Explains Mechanisms of Chronic Fatigue Syndrome and Fibromyalgia & Suggested Protocol"] *2007, Speaker at the 2nd [[Invest in ME International ME Conference]] - ''Biochemical Underpinnings of ME/CFS'' <ref name=":0" /> - [https://www.youtube.com/watch?v=cDwaj56n2UU (Video)] *2014, [https://www.youtube.com/watch?v=3kQQyU8NHv8 Martin Pall explains "Unexplained Illnesses"] (English with French subtitles) ==Publications on ME/CFS== *2000, Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome<ref>{{Cite journal | last = Pall|first = M.L. | authorlink = Martin Pall | date = Jan 2000 | title = Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome|url=https://linkinghub.elsevier.com/retrieve/pii/S0306987798908258|journal=Medical Hypotheses|language=en|volume=54|issue=1|pages=115–125|doi=10.1054/mehy.1998.0825|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [[pubmed:10790736|(Abstract)]] *2000, Elevated Peroxynitrite as the Cause of Chronic Fatigue Syndrome: Other Inducers and Mechanisms of Symptom Generation<ref>{{Cite journal | last = Pall|first = Martin L. | authorlink = Martin Pall | date = Jan 2000 | title = Elevated Peroxynitrite as the Cause of Chronic Fatigue Syndrome: Other Inducers and Mechanisms of Symptom Generation | url =http://www.tandfonline.com/doi/full/10.1300/J092v07n04_05|journal=Journal of Chronic Fatigue Syndrome|language=en|volume=7|issue=4 | pages = 45–58|doi=10.1300/J092v07n04_05|issn=1057-3321|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.tandfonline.com/doi/abs/10.1300/J092v07n04_05 (Abstract)] *2000, [[Cobalamin]] Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger<ref>{{Cite journal | last = Pall|first = Martin L. | authorlink = Martin Pall | date = Jan 2000 | title = Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger |url =http://www.tandfonline.com/doi/full/10.1300/J092v08n02_04|journal=Journal of Chronic Fatigue Syndrome|language=en|volume=8|issue=2 | pages = 39–44|doi=10.1300/J092v08n02_04|issn=1057-3321|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.tandfonline.com/doi/abs/10.1300/J092v08n02_04 (Abstract)] *2001, Common etiology of [[Post-traumatic stress disorder|posttraumatic stress disorder]], [[fibromyalgia]], chronic fatigue syndrome and [[multiple chemical sensitivity]] via elevated nitric oxide/peroxynitrite<ref>{{Cite journal | last = Pall|first = M.L. | authorlink = Martin Pall | date = Aug 2001 | title = Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite|url=https://www.ncbi.nlm.nih.gov/pubmed/11461161|journal=Medical Hypotheses|volume=57|issue=2|pages=139–145|doi=10.1054/mehy.2001.1325|issn=0306-9877|pmc=|pmid=11461161|access-date=|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/11461161 (Full text)] *2001, Elevated nitric oxide/peroxynitrite mechanism for the common etiology of [[multiple chemical sensitivity]], chronic fatigue syndrome, and [[Post-traumatic stress disorder|posttraumatic stress disorder]]<ref>{{Cite journal | last = Pall|first = M.L. | authorlink = Martin Pall | last2 = Satterlee | first2 = J.D. | authorlink2 = | date = Mar 2001 | title = Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder |url =https://www.ncbi.nlm.nih.gov/pubmed/12000033|journal=Annals of the New York Academy of Sciences|volume=933|issue= | pages = 323–329|doi=10.1111/j.1749-6632.2001.tb05836.x|issn=0077-8923|pmc=|pmid=12000033|access-date=|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/12000033 (Abstract)] *2002, Levels of Nitric Oxide Synthase Product Citrulline Are Elevated in Sera of Chronic Fatigue Syndrome Patients<ref>{{Cite journal | last = Pall|first = Martin L. | authorlink = Martin Pall | date = Jan 2002 | title = Levels of Nitric Oxide Synthase Product Citrulline Are Elevated in Sera of Chronic Fatigue Syndrome Patients|url=http://www.tandfonline.com/doi/full/10.1300/J092v10n03_04|journal=Journal of Chronic Fatigue Syndrome|language=en|volume=10|issue=3-4 | pages = 37–41|doi=10.1300/J092v10n03_04|issn=1057-3321|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [http://dx.doi.org/10.1300/J092v10n03_04 (Abstract)] *2002, Chronic fatigue syndrome/myalgic encephalitis<ref>{{Cite journal | last = Pall|first = Martin L. | authorlink = Martin Pall | date = Sep 2002 | title = Chronic fatigue syndrome/myalgic encephalitis|url=https://www.ncbi.nlm.nih.gov/pubmed/12236283|journal=The British Journal of General Practice: The Journal of the Royal College of General Practitioners|volume=52|issue=482 | pages = 762; author reply 763–764|doi=|issn=0960-1643|pmc=1314420|pmid=12236283|access-date=|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1314420/ (Full access)] *2003, Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients<ref>{{Cite journal | last = Smirnova | first = Iva V. | authorlink = | last2 = Pall | first2 = Martin | authorlink2 = Martin Pall | date = 2003 | title = Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients|url=http://link.springer.com/10.1023/A:1024176016962|journal=Molecular and Cellular Biochemistry|volume=248|issue=1/2 | pages = 93–95|doi=10.1023/A:1024176016962|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [[pubmed:12870659|(Abstract)]] *2005, Nitric oxide and the etiology of [[chronic fatigue syndrome]]: giving credit where credit is due<ref>{{Cite journal | last = Pall|first = Martin L. | authorlink = Martin Pall | date = Jan 2005 | title = Nitric oxide and the etiology of chronic fatigue syndrome: Giving credit where credit is due|url=https://linkinghub.elsevier.com/retrieve/pii/S0306987705001945|journal=Medical Hypotheses|language=en|volume=65|issue=3 | pages = 631–633|doi=10.1016/j.mehy.2005.03.026|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [[pubmed:15936892|(Abstract)]] * 2008, Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease<ref>{{Cite journal | last = Pall|first = Martin L. | authorlink = Martin Pall | date = Oct 2008 | title = Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease|url=https://www.ncbi.nlm.nih.gov/pubmed/18667279|journal=Medical Hypotheses|volume=71|issue=4 | pages = 537–541|doi=10.1016/j.mehy.2008.05.023|issn=0306-9877|pmc=|pmid=18667279|access-date=|quote=|via=}}</ref> - [[pubmed:18667279|(Abstract)]] *2011, Myalgic encephalomyelitis: [[International Consensus Criteria]]<ref>{{Cite journal | last = Carruthers | first = Bruce M. | authorlink = Bruce Carruthers | last2 = van de Sande | first2 = Marjorie I. | authorlink2 = Marjorie van de Sande | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Klimas | first4 = Nancy G. | author-link4 = Nancy Klimas | last5 = Broderick | first5 = Gordon | author-link5 = Gordon Broderick | last6 = Mitchell | first6 = Terry | authorlink6 = Terry Mitchell | last7 = Staines | first7 = Donald | author-link7 = Donald Staines | last8 = Powles | first8 = A.C. Peter | authorlink8 = A C Peter Powles | last9 = Speight | first9 = Nigel | authorlink9 = Nigel Speight | last10 = Vallings | first10 = Rosamund | authorlink10 = Rosamund Vallings | last11 = Bateman | first11 = Lucinda | authorlink11 = Lucinda Bateman | last12 = Baumgarten-Austrheim | first12 = Barbara | authorlink12 = Barbara Baumgarten-Austrheim | last13 = Bell | first13 = David | author-link13 = David Bell | last14 = Carlo-Stella | first14 = Nicoletta | author-link14 = Nicoletta Carlo-Stella | last15 = Chia | first15 = John | author-link15 = John Chia | last16 = Darragh | first16 = Austin | author-link16 = Austin Darragh | last17 = Jo | first17 = Daehyun | author-link17 = Daehyun Jo | last18 = Lewis | first18 = Donald | author-link18 = Donald Lewis | last19 = Light | first19 = Alan | author-link19 = Alan Light | last20 = Marshall-Gradisnik | first20 = Sonya | author-link20 = Sonya Marshall-Gradisnik | last21 = Mena | first21 = Ismael | author-link21 = Ismael Mena | last22 = Mikovits | first22 = Judy | author-link22 = Judy Mikovits | last23 = Miwa | first23 = Kunihisa | author-link23 = Kunihisa Miwa | last24 = Murovska | first24 = Modra | author-link24 = Modra Murovska | last25 = Pall | first25 = Martin | author-link25 = Martin Pall | last26 = Stevens | first26 = Staci | author-link26 = Staci Stevens | date = 2011-08-22 | title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4 | pages = 327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> - [https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2796.2011.02428.x (Full text)] *2011, Will [[vitamin D]] supplementation ameliorate diseases characterized by chronic inflammation and fatigue?<ref>{{Cite journal | last = Hoeck|first = Anna Dorothea | authorlink = Anna Dorothea Hoeck | last2 = Pall | first2 = Martin L. | authorlink2 = Martin Pall | date = Feb 2011 | title = Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue?|url=https://linkinghub.elsevier.com/retrieve/pii/S0306987710003981|journal=Medical Hypotheses|language=en|volume=76|issue=2|pages=208–213|doi=10.1016/j.mehy.2010.09.032|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.sciencedirect.com/science/article/abs/pii/S0306987710003981?via%3Dihub (Abstract)] ==Online presence== *[https://www.researchgate.net/profile/Martin_Pall ResearchGate] ==See also== *[[Anna Dorothea Hoeck]] *[[N-acetylcysteine]] *[[Nitric oxide hypothesis]] ==References== {{reflist}} [[Category:Researchers]] [[Category:US researchers]] [[Category:People with ME, CFS, and/or FMS]] [[Category:Authors]]
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