Gerwyn Morris

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Gerwyn Morris is an independent researcher with expertise in Microbiology, Cell Biology, and Immunology.[1] He is affiliated with IMPACT Strategic Research Centre, School of Medicine, Deakin University, Barwon Health, Geelong, Victoria, Australia.[2]

Notable studies[edit | edit source]

  • 2013, A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior[3] - (Full text)
  • 2013, In myalgic encephalomyelitis/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation[4] - (Abstract)
  • 2013, Case definitions and diagnostic criteria for Myalgic Encephalomyelitis and Chronic fatigue Syndrome: from clinical-consensus to evidence-based case definitions[5] - (Full text)
  • 2013, Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics[6] - (Abstract)
  • 2014, The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs)[7] - (Full text)
  • 2014, Review Article - Mitochondrial dysfunctions in Myalgic Encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways[8] - (Abstract)
  • 2014, Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)[9] - (Full Text)
  • 2015, Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses[10] - (Full Text)
  • 2016, The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease[11] - (Abstract)
  • 2016, The Many Neuroprogressive Actions of Tryptophan Catabolites (TRYCATs) that may be Associated with the Pathophysiology of Neuro-Immune Disorders[12] - (Abstract)
  • 2016, The deleterious effects of oxidative and nitrosative stress on palmitoylation, membrane lipid rafts and lipid-based cellular signalling: new drug targets in neuroimmune disorders[13] - (Full text)
  • 2016, The Putative Role of Viruses, Bacteria, and Chronic Fungal Biotoxin Exposure in the Genesis of Intractable Fatigue Accompanied by Cognitive and Physical Disability[14] - (Abstract)
  • 2016, The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases[15] (Abstract)
  • 2016, Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome[16] - (Abstract)
  • 2016, The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimmune processes with an emphasis on Inflammatory Bowel Disease Type 1 Diabetes and Chronic Fatigue Syndrome[17] - (Abstract)
  • 2017, Hypothalamic-Pituitary-Adrenal Hypofunction in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) as a Consequence of Activated Immune-Inflammatory and Oxidative and Nitrosative Pathways[18] - (Abstract)
  • 2017, A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause?[19] - (Full Text)
  • 2017, Mechanisms Explaining Muscle Fatigue and Muscle Pain in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a Review of Recent Findings[20] - (Full Text)
  • 2018, The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis[21] - (Abstract)
  • 2019, The compensatory antioxidant response system with a focus on neuroprogressive disorders[22] - (Abstract)
  • 2019, Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders[23] - (Abstract)
  • 2019, Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?[24] - (Full text)
  • 2019, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: From Pathophysiological Insights to Novel Therapeutic Opportunities[2] - (Abstract)
  • 2019, Editorial - Is a diagnostic blood test for chronic fatigue syndrome on the horizon?[25] - (Full text)
  • 2021, The lipid paradox in neuroprogressive disorders: Causes and consequences[26] - (Full text)
  • 2021, Intertwined associations between oxidative and nitrosative stress and endocannabinoid system pathways: Relevance for neuropsychiatric disorders[27] - (Abstract)

Talks and interviews[edit | edit source]

Online presence[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. ↑ "Gerwyn Morris | Independent Researcher". ResearchGate. Retrieved September 23, 2019.
  2. ↑ 2.0 2.1 Morris, Gerwyn; Puri, Basant K.; Walker, Adam J.; Maes, Michael; Carvalho, Andre F.; Walder, Ken; Mazza, Catherine; Berk, Michael (September 2019). "Myalgic encephalomyelitis/chronic fatigue syndrome: From pathophysiological insights to novel therapeutic opportunities". Pharmacological Research. 148: 104450. doi:10.1016/j.phrs.2019.104450. PMID 31509764.
  3. ↑ Morris, Gerwyn; Anderson, George; Galecki, Piotr; Berk, Michael; Maes, Michael (March 8, 2013). "A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior". BMC Medicine. 11 (1): 64. doi:10.1186/1741-7015-11-64. ISSN 1741-7015. PMC 3751187. PMID 23497361.
  4. ↑ Maes, Michael; Ringel, Karl; Kubera, Marta; Anderson, George; Morris, Gerwyn; Galacki, Piotr; Geffard, Michel (September 5, 2013). "In myalgic encephalomyelitis/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation". Journal of Affective Disorders. 150 (2): 223-230. doi:10.1016/j.jad.2013.03.029.
  5. ↑ Morris, Gerwyn; Maes, Michael (2013). "Case definitions and diagnostic criteria for Myalgic Encephalomyelitis and Chronic fatigue Syndrome: from clinical-consensus to evidence-based case definitions". Neuro Endocrinology Letters. 34 (3): 185-99. PMID 23685416.
  6. ↑ Morris, Gerwyn; Maes, Michael (2013). "Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics". BMC Medicine. 11: 205. doi:10.1186/1741-7015-11-205. ISSN 1741-7015.
  7. ↑ Morris, Gerwyn; Berk, Michael; Galacki, Piotr; Maes, Michael (2014). "The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs)". Molecular Neurobiology. 49 (2): 741-756. doi:10.1007/s12035-013-8553-0. PMID 24068616.
  8. ↑ Morris, Gerwyn; Maes, Michael (2014). "Mitochondrial dysfunctions in Myalgic Encephalomyelitis / chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways". Metabolic Brain Disease. 29 (19). doi:10.1007/s11011-013-9435-x.
  9. ↑ Morris, Gerwyn; Maes, Michael (2014). "Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)". Current Neuropharmacology. 12 (2): 168–185. doi:10.2174/1570159X11666131120224653. PMC 3964747.
  10. ↑ Morris, Gerwyn; Berk, Michael; Walder, K; Maes, Michael (2015). "Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses". BMC Medicine. 13 (28). doi:10.1186/s12916-014-0259-2.
  11. ↑ Morris, Gerwyn; Berk, Michael; Carvalho, Andre; Caso, Javier R.; Sanz, Yolanda; Walder, Ken; Maes, Michael; Michael Maes (August 1, 2017). "The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease". Molecular Neurobiology. 54 (6): 4432–4451. doi:10.1007/s12035-016-0004-2. ISSN 1559-1182.
  12. ↑ Morris, Gerwyn; Carvalho, André F.; Anderson, George; Galecki, Piotr; Maes, Michael (2016). "The Many Neuroprogressive Actions of Tryptophan Catabolites (TRYCATs) that may be Associated with the Pathophysiology of Neuro-Immune Disorders". Current Pharmaceutical Design. 22 (8): 963–977. doi:10.2174/1381612822666151215102420. ISSN 1873-4286. PMID 26667000.
  13. ↑ Morris, Gerwyn; Walder, Ken; Puri, Basant K.; Berk, Michael; Maes, Michael (September 1, 2016). "The Deleterious Effects of Oxidative and Nitrosative Stress on Palmitoylation, Membrane Lipid Rafts and Lipid-Based Cellular Signalling: New Drug Targets in Neuroimmune Disorders". Molecular Neurobiology. 53 (7): 4638–4658. doi:10.1007/s12035-015-9392-y. ISSN 1559-1182.
  14. ↑ Morris, Gerwyn; Berk, Michael; Walder, Ken; Maes, Michael (May 2016). "The Putative Role of Viruses, Bacteria, and Chronic Fungal Biotoxin Exposure in the Genesis of Intractable Fatigue Accompanied by Cognitive and Physical Disability". Molecular Neurobiology. 53 (4): 2550–2571. doi:10.1007/s12035-015-9262-7. ISSN 1559-1182. PMID 26081141.
  15. ↑ Morris, Gerwyn; Berk, Michael; Galecki, Piotr; Walder, Ken; Maes, Michael (March 2016). "The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases". Molecular Neurobiology. 53 (2): 1195–1219. doi:10.1007/s12035-015-9090-9. ISSN 1559-1182. PMID 25598355.
  16. ↑ Morris, Gerwyn; Berk, Michael; Klein, H.; Walder, K.; Galacki, Piotr; Maes, Michael (June 23, 2016). "Nitrosative Stress, Hypernitrosylation, and Autoimmune Responses to Nitrosylated Proteins: New Pathways in Neuroprogressive Disorders Including Depression and Chronic Fatigue Syndrome". Molecular Neurobiology. 54: 4271–4291. doi:10.1007/s12035-016-9975-2.
  17. ↑ Morris, Gerwyn; Berk, Michael; Carvalho, A.F.; Caso, J.R.; Sanz, Y.; Maes, Michael (2016). "The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimmune processes with an emphasis on Inflammatory Bowel Disease Type 1 Diabetes and Chronic Fatigue Syndrome". Current Pharmaceutical Design. 22 (40): 6058-6075. PMID 27634186.
  18. ↑ Morris, Gerwyn; Anderson, George; Maes, Michael (November 2017). "Hypothalamic-Pituitary-Adrenal Hypofunction in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) as a Consequence of Activated Immune-Inflammatory and Oxidative and Nitrosative Pathways". Molecular Neurobiology. 54 (9): 6806–6819. doi:10.1007/s12035-016-0170-2. ISSN 1559-1182. PMID 27766535.
  19. ↑ Morris, Gerwyn; Berk, Michael; Puri, Basant K. (2017). "A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause?". Mol Neurobiology. 55 (4): 3592–3609. doi:10.1007/s12035-017-0598-z.
  20. ↑ Morris, Gerwyn; Maes, Michael (2017). "Mechanisms Explaining Muscle Fatigue and Muscle Pain in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a Review of Recent Findings". Current Rheumatology Reports. 19 (1). doi:10.1007/s11926-017-0628-x.
  21. ↑ Morris, Gerwyn; Stubbs, Brendon; Köhler, Cristiano A.; Walder, Ken; Slyepchenko, Anastasiya; Berk, Michael; Carvalho, André F. (2018). "The putative role of Oxidative Stress and Inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders : Focus on Chronic Fatigue Syndrome, Bipolar Disorder and Multiple Sclerosis". Sleep Med Reviews. 41: 255–265. doi:10.1016/j.smrv.2018.03.007. PMID 29759891.
  22. ↑ Morris, Gerwyn; Puri, Basant K.; Walker, Adam J.; Berk, Michael; Walder, Ken; Bortolasci, Chiara C.; Marx, Wolfgang; Carvalho, Andre F.; Maes, Michael (December 20, 2019). "The compensatory antioxidant response system with a focus on neuroprogressive disorders". Progress in Neuro-Psychopharmacology and Biological Psychiatry. 95: 109708. doi:10.1016/j.pnpbp.2019.109708. ISSN 0278-5846.
  23. ↑ Morris, Gerwyn; Puri, Basant K.; Walker, Adam J.; Maes, Michael; Carvalho, Andre F.; Bortolasci, Chiara C.; Walder, Ken; Berk, Michael (December 1, 2019). "Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders". Neuroscience & Biobehavioral Reviews. 107: 862–882. doi:10.1016/j.neubiorev.2019.09.025. ISSN 0149-7634.
  24. ↑ Morris, Gerwyn; Maes, Michael; Berk, Michael; Puri, Basant K. (February 13, 2019). "Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?". Metabolic Brain Disease. doi:10.1007/s11011-019-0388-6. ISSN 0885-7490. PMID 30758706.
  25. ↑ Maes, Michael; Rodriguez, Laura Andres; Morris, Gerwyn (October 18, 2019). "Is a diagnostic blood test for chronic fatigue syndrome on the horizon?". Expert Review of Molecular Diagnostics. 19 (12): 1049–1051. doi:10.1080/14737159.2020.1681976. ISSN 1473-7159.
  26. ↑ Morris, Gerwyn; Berk, Michael; Walder, Ken; O'Neil, Adrienne; Maes, Michael; Puri, Basant K. (September 1, 2021). "The lipid paradox in neuroprogressive disorders: Causes and consequences". Neuroscience & Biobehavioral Reviews. 128: 35–57. doi:10.1016/j.neubiorev.2021.06.017. ISSN 0149-7634.
  27. ↑ Morris, Gerwyn; Walder, Ken; Berk, Michael; Carvalho, Andre F.; Marx, Wolf; Bortolasci, Chiara C.; Yung, Alison R.; Puri, Basant K.; Maes, Michael (November 24, 2021). "Intertwined associations between oxidative and nitrosative stress and endocannabinoid system pathways: Relevance for neuropsychiatric disorders". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 114: 110481. doi:10.1016/j.pnpbp.2021.110481. ISSN 1878-4216. PMID 34826557.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

chronic fatigue (CF) - Persistent and abnormal fatigue is a symptom, not an illness. It may be caused by depression, multiple sclerosis, fibromyalgia, chronic fatigue syndrome or many other illnesses. The term "chronic fatigue" should never be confused with the disease chronic fatigue syndrome.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

mitochondria Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

stress Stress can by either physical or psychological, or both. Stress is either 1) a state of emotional or psychological strain or 2) the physical stress (pressure or tension) that a physical object such the human body is placed under, e.g., a stress test is a medical test that monitors the cardiovascular system during strenuous exercise.

metabolite A chemical compound produced by, or involved in, metabolism. The term is often used to refer to the degradation products of drugs in the body.

membrane The word "membrane" can have different meanings in different fields of biology. In cell biology, a membrane is a layer of molecules that surround its contents. Examples of cell-biology membranes include the "cell membrane" that surrounds a cell, the "mitochondrial membranes" that form the outer layers of mitochondria, and the "viral envelope" that surrounds enveloped viruses. In anatomy or tissue biology, a membrane is a barrier formed by a layer of cells. Examples of anatomical membranes include the pleural membranes that surrounds the lungs, the pericardium which surrounds the heart, and some of the layers within the blood-brain barrier.

cognition Thought processes, including attention, reasoning, and memory.

microbiome The full collection of microscopic organisms (especially bacteria and fungi) which are present in a particular environment, particularly inside the human body.

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