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=== Electrical activity === 2016, A qEEG/LORETA study of nine controls and nine CFS patients (per [[DePaul Symptom Questionnaire]] (DSQ) and [[Canadian Consensus Criteria]] (CCC) definitions), found significantly decreased eLORETA source analysis oscillations in the occipital, parietal, posterior cingulate, and posterior temporal lobes in Alpha and Alpha-2. This research suggests that "disruptions in these regions and networks could be a neurobiological feature of the disorder, representing underlying neural dysfunction."<ref name="Zinn2016P2">{{Citation | last1 = Zinn | first1 = Marcie | author-link1 = Marcie Zinn | last2 = Zinn | first2 = Mark| author-link2 = Mark Zinn | last3 = Jason | first3 = Leonard | author-link3 = Leonard Jason | title = Intrinsic Functional Hypoconnectivity in Core Neurocognitive Networks Suggests Central Nervous System Pathology in Patients with Myalgic Encephalomyelitis: A Pilot Study | journal = Applied Psychophysiology and Biofeedback | volume = 41 | issue = 3 | page = 283-300 | date = 2016 | pmid = 26869373 | doi = 10.1007/s10484-016-9331-3 }}</ref> 2016, A qEEG/LORETA study of one CFS patient (per DSQ and CCC definitions), found deregulation of the functional connectivity networks. This may explain the common symptom of perceived cognitive deficits such as [[slowed thought|slow thinking]], difficulty in reading comprehension, reduced learning and [[memory problems|memory abilities]] and an overall feeling of being in a “[[Brain fog|fog]]".<ref name="sciforschenonline" /> [[File:CLROA-2-110-F1.gif|850px|thumb|center|Figure 1: Results of LORETA current source density in a case with CFS showing widespread decreased current density for delta at 2 Hz and beta (12- 15 Hz) demonstrating a global reduction in brain functioning (blue). The higher frequencies (beta) have been shown to be a function of delta frequencies. In other words, local oscillations are under constant influence of global brain dynamics (Buzsaki, 2006).<ref name="sciforschenonline">{{Cite web | url = https://www.sciforschenonline.org/journals/clinical-research/CLROA-2-110.php | title = qEEG / LORETA in Assessment of Neurocognitive Impairment in a Patient with Chronic Fatigue Syndrome: A Case Report | last = Zinn | first = Marcie L | author-link = Marcie Zinn | date = 2016 | website = sciforschenonline.org|archive-url=|archive-date= | access-date = 2018-08-28 | last2 = Zinn | author-link2 = Mark Zinn | first2 = Mark A. | last3 = Jason | first4 = | first3 = Leonard|issn=2469-6714| publisher = SciForschen|doi=10.16966/2469-6714.110}}</ref>|link=https://www.me-pedia.org/wiki/File:CLROA-2-110-F1.gif]]
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