Jackson Laboratory ME/CFS Collaborative Research Center
The Jackson Laboratory ME/CFS Collaborative Research Center was created in 2017 when the Jackson Lab (JAX) led by Derya Unutmaz was awarded a five-year grant totaling $10,553,732 from the National Institutes of Health for one of the country's first Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Collaborative Research Centers (CRC). This CRC will work in conjunction with Drs. Lucinda Bateman and Suzanne Vernon at the Bateman Horne Center of Salt Lake City, Utah; Dr. Xudong Yao at the University of Connecticut; Dr. Alison Motsinger-Reif at North Carolina State University and Precise.ly, a San Francisco-based company. The CRC's focus will be on the topological mapping of immune, microbiota, metabolomic and clinical phenotypes in ME/CFS.
References[edit | edit source]
- Peterson, Joyce Dall'Acqua. "NIH awards $10.6M research center grant to The Jackson Laboratory for study of chronic fatigue syndrome". The Jackson Laboratory. Retrieved April 5, 2019.
- "NIH announces centers for myalgic encephalomyelitis/chronic fatigue syndrome research". National Institutes of Health (NIH). September 27, 2017. Retrieved April 5, 2019.
- "Project Information - NIH RePORTER - NIH Research Portfolio Online Reporting Tools Expenditures and Results". projectreporter.nih.gov. Retrieved April 5, 2019.
myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.
microbiome The full collection of microscopic organisms (especially bacteria and fungi) which are present in a particular environment, particularly inside the human body.
metabolomics The analysis of the chemical metabolism within cells, tissues or organisms. The term is often used to refer to the full set of metabolites found in a cell in a given environment.