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Succinate dehydrogenase
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'''Succinate dehydrogenase'''Β or '''SDH''' is an enzyme involved in the [[Citric acid cycle|Kreb's cycle]]. It oxidizes [[succinate]] to fumarate. It is also known as succinate-[[coenzyme Q]] reductase or respiratory [[Complex II]]. ==ME/CFS == A small study of [[chronic fatigue syndrome]] patients found an inversion of the [[cytochrome oxidase]]/succinate dehydrogenase ratio in [[Muscle biopsy|muscle biopses]].<ref>{{Cite journal | last = Vecchiet | first = L | date = April 1996 | title = Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/8859904|journal=Neuroscience Letters|volume=208|pages=117-20|via=}}</ref> A study of [[poliovirus]] found that polio infection rapidly decreases cellular oxygen consumption (and thus energy production through [[cellular respiration]]) by inhibiting succinate dehydrogenase and blocking [[mitochondrion|mitochondrial]] electron transport.<ref>{{Cite journal|url=https://www.ncbi.nlm.nih.gov/pubmed/10814509 | title = Poliovirus Induces an Early Impairment of Mitochondrial Function by Inhibiting Succinate Dehydrogenase Activity | last = Koundouris | first = A | date = May 2000|journal=Biochemical and Biophysical Research Communications|volume=271 | pages = 610-4|via=}}</ref> ==See also == *[[Citric acid cycle]] ==Learn more == == References == {{Reflist}} [[Category:Enzymes]]
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