Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Nora Chapman
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
[[File:Nora M. Chapman.png|thumb|right|Source:University of Nebraska]] '''Nora M. Chapman''', Ph.D., is a Professor in the department of Pathology and Microbiology, at the College of Medicine, University of Nebraska. Her interests are in virology and molecular biology and is part of the University's Enterovirus Research Group.<ref>http://www.unmc.edu/pathology/faculty/bios/chapman.html</ref> Dr. Chapman and her associates at the University of Nebraska are working to collabrate Dr. [[John Chia]]'s work on enteroviruses being present in gut biopsies of patients with [[ME/CFS]].<ref>{{Cite web|url=http://www.investinme.org/IIMEC5.shtml | title = Invest in ME Research - IIMEC5 International ME Conference 2010|last = Invest in ME Research | website = [[Invest in ME Research]] |access-date=2018-08-08}}</ref> She serves on the Board of Directors of the Enterovirus Foundation.<ref>{{Cite web|url=https://www.enterovirusfoundation.org/our-community-1/ | title = Our Community|website=Enterovirus Foundation|language=en-US|access-date=2018-08-08}}</ref> In a landmark 2005 paper,<ref>{{Cite journal | last = Kim | first = K.-S. | last2 = Tracy | first2 = S. | last3 = Tapprich | first3 = W. | last4 = Bailey | first4 = J. | last5 = Lee | first5 = C.-K. | last6 = Kim | first6 = K. | last7 = Barry | first7 = W.H. | last8 = Chapman | first8 = N.M. | authorlink8 = Nora Chapman | date = Jun 2005 | title = 5'-Terminal deletions occur in coxsackievirus B3 during replication in murine hearts and cardiac myocyte cultures and correlate with encapsidation of negative-strand viral RNA|url=https://www.ncbi.nlm.nih.gov/pubmed/15890942|journal=Journal of Virology|volume=79|issue=11 | pages = 7024–7041|doi=10.1128/JVI.79.11.7024-7041.2005|issn=0022-538X|pmc=1112132|pmid=15890942}}</ref> Prof Chapman discovered the mechanism by which a normal lytic enterovirus can get transformed into an aberrant non-cytolytic virus capable of producing persistent low-level infections. The mechanism of transformation involves mutations that the virus acquires during the acute infection in the host: see [[non-cytolytic enterovirus]]. This has importance for ME/CFS, which has long been associated with persistent non-cytolytic enteroviral infections of the muscle, brain and stomach tissues. ==Education== *B.A. (Highest Honors), University of California, Santa Cruz, 1975 *Ph.D., Harvard University, Cambridge, MA, 1981 ==Talks and interviews== *2008: International Symposium on Viruses In CFS and Post-Viral Fatigue: [https://www.youtube.com/watch?v=3Ro7UlhSD-w ''How does a lytic enterovirus infection persist and cause chronic disease?'']. *2009: [http://www.investinme.org/ArticleJ31-Human%20Enteroviruses%20and%20Chronic%20Infectious%20Disease.shtml ''Human Enteroviruses and Chronic Infectious Disease''.] Steven Tracy and Nora M. Chapman. Journal of IiME, Vol 3, Issue 1, pages 23-31. Also [http://www.investinme.org/Documents/Journals/Journal%20of%20IiME%20Vol%203%20Issue%201%20Screen.pdf available as pdf] (pages 23-31). *2010: Prof Nora M. Chapman, [https://www.youtube.com/watch?v=d4ZBlR2AA5o Invest in ME International ME Conference, London 2010]: Persistent Enteroviral Infections. *2012: [https://www.jdrfnpod.org/wordpress/wp-content/uploads/2013/08/1a-chapman.pdf ''Replication Defective Enterovirus Infections: Implications for Type I Diabetes'']. Slides from a presentation at the [https://www.jdrfnpod.org/for-investigators/2012-npod-annual-meeting-presentations-for-distribution/ 2012 Annual Meeting] of the Network for Pancreatic Organ Donors with Diabetes. *2013: [https://www.youtube.com/watch?v=bm5A9pZ78xk ''Human Enterovirus Persistence: Potential for Exacerbation of Myocarditis'']. International Academy of Cardiology: 18th World Congress on Heart Disease, 2013 Vancouver, Canada. ==Book chapter== *2008, Persistent Coxsackievirus Infection: Enterovirus Persistence in Chronic Myocarditis and Dilated Cardiomyopathy. In: Tracy S., Oberste M.S., Drescher K.M. (eds) Group B Coxsackieviruses. Current Topics in Microbiology and Immunology, vol 323. Springer, Berlin, Heidelberg<ref>{{Cite book | last = Chapman | first = N.M. | authorlink = Nora Chapman | last2 = Kim | first2 = K. -S. | date = 2008|chapter=Persistent Coxsackievirus Infection: Enterovirus Persistence in Chronic Myocarditis and Dilated Cardiomyopathy|url=http://link.springer.com/10.1007/978-3-540-75546-3_13|journal=|language=en|location=Berlin, Heidelberg|publisher=Springer | title = Current Topics in Microbiology and Immunologyvolume=vol 323|pages=275–292|doi=10.1007/978-3-540-75546-3_13|isbn=9783540755456|via=}}</ref> [https://link.springer.com/chapter/10.1007/978-3-540-75546-3_13 (Preview)] ==Notable studies== * 2002, Toward Testing the Hypothesis that Group B Coxsackieviruses (CVB) Trigger Insulin-Dependent Diabetes: Inoculating Nonobese Diabetic Mice with CVB Markedly Lowers Diabetes Incidence<ref>{{Cite journal | last = Tracy | first = S. | last2 = Drescher | first2 = K.M. | last3 = Chapman | first3 = N.M. | author-link3 =Nora Chapman | last4 = Kim | first4 = K.-S. | last5 = Carson | first5 = S. D. | last6 = Pirruccello | first6 = S. | last7 = Lane | first7 = P.H. | last8 = Romero | first8 = J.R. | last9 = Leser | first9 = J.S. | date = Dec 2002 | title = Toward testing the hypothesis that group B coxsackieviruses (CVB) trigger insulin-dependent diabetes: inoculating nonobese diabetic mice with CVB markedly lowers diabetes incidence|url=https://www.ncbi.nlm.nih.gov/pubmed/12414951|journal=Journal of Virology|volume=76|issue=23|pages=12097–12111|doi=10.1128/JVI.76.23.12097-12111.2002|issn=0022-538X|pmc=|pmid=12414951|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC136885/ (Full Text)] * 2022, Persistent Enterovirus Infection: Little Deletions, Long Infections.<ref>{{Cite journal|title=Persistent Enterovirus Infection: Little Deletions, Long Infections|date=2022-05-12|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143164/|journal=Vaccines|volume=10|issue=5|pages=770|last=Chapman|first=Nora M.|doi=10.3390/vaccines10050770|pmc=9143164|pmid=35632526|issn=2076-393X}}</ref> == See also == * [[Coxsackievirus]] * [[Non-cytolytic enterovirus]] ==References== {{Reflist}} [[Category:Researchers]] [[Category:US researchers]] <references />
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Templates used on this page:
Template:Cite book
(
edit
)
Template:Cite journal
(
edit
)
Template:Cite web
(
edit
)
Template:Main other
(
edit
)
Template:Reflist
(
edit
)
Module:Check for unknown parameters
(
edit
)
Module:Citation/CS1
(
edit
)
Module:Citation/CS1/COinS
(
edit
)
Module:Citation/CS1/Configuration
(
edit
)
Module:Citation/CS1/Date validation
(
edit
)
Module:Citation/CS1/Identifiers
(
edit
)
Module:Citation/CS1/Utilities
(
edit
)
Module:Citation/CS1/Whitelist
(
edit
)
Module:No globals
(
edit
)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs