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T helper cell
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== Th2 == {{bookmark|Th2}} Th2 cells are a subset of T helper cells that are involved in humoral immunity against extracellular parasites, bacteria, toxins and allergens. They are triggered by IL-4 and their effector [[cytokines]] are IL-4, [[Interleukin 5|IL-5]], [[Interleukin 9|IL-9]], [[Interleukin 10|IL-10]] and [[Interleukin 13|IL-13]]. The main effector cells are [[Eosinophil|eosinophils]], [[Basophil granulocyte|basophils]], and [[Mast cell|mast cells]] as well as [[B cell|B cells]], and [[Interleukin 4|IL-4]]/[[Interleukin 5|IL-5]] [[CD4 T cell]]s. Autoimmune diseases characterized by a Th2 immune profile include [[Lupus]], scleroderma, i[[Inflammatory bowel disease|nflammatory bowel disease]], and [[Asthma]].{{Citation needed}} [[Chronic fatigue syndrome]] may be characterized by a Th2 [[cytokine]] profile.<ref>{{Cite journal | last =Skowera | first=A. | author-link = Anna Showera | last2 = Cleare | first2 = A. | authorlink2 = Anthony Cleare | last3 = Blair | first3= D. | authorlink3 = Dorothy Blair | last4 = Bevis | first4 = L. | authorlink4 = L Bevis | last5 = Wessely | first5 = S.C. | authorlink5 = Simon Wessely | last6 = Peakman | first6 = M. | authorlink6 = Mark Peakman | date = Feb 2004 | title = High levels of type 2 cytokine-producing cells in chronic fatigue syndrome|url=https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2249.2004.02354.x|journal=[[Clinical and Experimental Immunology]]|language=en|volume=135|issue=2|pages=294β302|doi=10.1111/j.1365-2249.2004.02354.x|issn=0009-9104|pmc=1808936|pmid=14738459|quote=|via=}}</ref><ref>{{Cite journal | last =Patarca | first = Roberto | author-link =Roberto Patarca-Montero | date = 2001 | title=Cytokines and Chronic Fatigue Syndrome|url=https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.2001.tb05824.x|journal=Annals of the New York Academy of Sciences|language=en|volume=933|issue=1|pages=185β200|doi=10.1111/j.1749-6632.2001.tb05824.x|issn=1749-6632|quote=|via=}}</ref>
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