Citric acid cycle

Citric acid cycle

Simply put, the Citric acid cycle/Krebs cycle/TCA cycle is a series of enzyme-catalyzed chemical reactions that form a key part of aerobic respiration in cells. This work takes place inside the mitochondria.

A recent paper started to define how and why people with ME (pwME) have poorly functioning cellular respirationwhile a review of published papers added empirical evidence of a relationship between mitochondrial dysfunction and fatigue.

According to Ron Davis, speaking at the 2016 IACFS/ME conference, ""ME/CFS patients have a marked decrease in some of the Citric Acid Cycle metabolites while mitochondrial mutations generally cause an increase."

Learn more

• Wikipedia - Citric acid cycle
• Krebs / citric acid cycle | Cellular respiration | tricarboxylic acid cycle| Biology | Khan Academy

See also

• Cellular respiration

enzyme a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

mitochondria Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

metabolite A chemical compound produced by, or involved in, metabolism. The term is often used to refer to the degradation products of drugs in the body.