Citric acid cycle

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Citric Acid Cycle

The Citric Acid Cycle (Krebs Cycle/TCA Cycle) is a series of enzyme-catalyzed chemical reactions that allow for aerobic respiration to occur within the mitochondria of the cell. When this cycle or its associated parts[1] are not functioning properly subsequent fatigue may take place.

A recent paper started to define how and why people with ME/CFS (pwME) might experience poorly functioning cellular respiration[2]while a review of published papers [3] added empirical evidence of a relationship between mitochondrial dysfunction and fatigue.

According to Ron Davis, speaking at the 2016 IACFS/ME conference, ""ME/CFS patients have a marked decrease in some of the Citric Acid Cycle metabolites while mitochondrial mutations generally cause an increase."[4]


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The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history