Brain-derived neurotrophic factor: Difference between revisions
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'''Brain-derived neurotrophic factor''' or '''BDNF''' is a protein in the neurotrophic family.<ref name="PMC2504526">{{Cite journal|last=Binder|first=Devin K.|author-link=|last2=Scharfman|first2=Helen E.|author-link2=|date=Sep 2004|title=Brain-derived Neurotrophic Factor|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504526/|journal=Growth factors (Chur, Switzerland)|volume=22|issue=3|pages=123–131|doi=10.1080/08977190410001723308|issn=0897-7194|pmc=2504526|pmid=15518235|access-date=|quote=|via=}}</ref> The name BDNF is also used to refer to the related gene that expresses BDNF.<ref name="PMC2504526" /> | '''Brain-derived neurotrophic factor''' or '''BDNF''' is a protein in the neurotrophic family.<ref name="PMC2504526">{{Cite journal | last = Binder | first = Devin K. | author-link = | last2 = Scharfman | first2 = Helen E. | author-link2 = | date = Sep 2004 | title = Brain-derived Neurotrophic Factor |url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504526/ | journal = Growth factors (Chur, Switzerland) | volume = 22 | issue = 3 | pages = 123–131|doi=10.1080/08977190410001723308|issn=0897-7194|pmc=2504526|pmid=15518235|access-date=|quote=|via=}}</ref> The name BDNF is also used to refer to the related gene that expresses BDNF.<ref name="PMC2504526" /> | ||
==Function== | ==Function== | ||
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==Notable studies == | ==Notable studies == | ||
*2015, Exercise and caffeine improve sustained attention following fatigue independent of fitness status<ref name="Kumar2015">{{Cite journal|title=Exercise and caffeine improve sustained attention following fatigue independent of fitness status|date=2015-04-03|url=https://doi.org/10.1080/21641846.2015.1027553|journal=Fatigue: Biomedicine, Health & Behavior|volume=3|issue=2|pages=104–121|last=Kumar|first=Namrita|last2=Wheaton|first2=Lewis A.|last3=Snow|first3=Teresa K.|last4=Millard-Stafford|first4=Melinda|doi=10.1080/21641846.2015.1027553|issn=2164-1846}}</ref> - [https://web.archive.org/web/20190225113231id_/http://pdfs.semanticscholar.org/61f9/b87e28a4902e1cc01250fca88dd39221256f.pdf (Full text)] | *2015, Brain-derived neurotrophic factor concentration may not be depressed in chronic fatigue syndrome<ref name="Patrick2015">{{Cite journal | title = Brain-derived neurotrophic factor concentration may not be depressed in chronic fatigue syndrome | date = 2015-04-03 | url = https://doi.org/10.1080/21641846.2015.1024004|journal = Fatigue: Biomedicine, Health & Behavior | volume = 3 | issue = 2 | pages = 122–125 | last = Patrick | first = David M. | last2 = Miller | first2 = Ruth R. | last3 = Steiner | first3 = Theodore | last4 = Gardy | first4 = Jennifer L. | last5 = Parker | first5 = Shoshana M. | last6 = Tang | first6 = Patrick|doi=10.1080/21641846.2015.1024004|issn=2164-1846}}</ref> - [https://www.tandfonline.com/doi/full/10.1080/21641846.2015.1024004 (Abstract)] | ||
*2015, Brain-derived neurotrophic factor (BDNF) as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?<ref name="Nijs2015">{{Cite journal|title=Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?|date=Apr 2015|url=https://pubmed.ncbi.nlm.nih.gov/25519921/|journal=Expert Opinion on Therapeutic Targets|volume=19|issue=4|pages=565–576|last=Nijs|first=Jo|author-link=Jo Nijs|last2=Meeus|first2=Mira|author-link2=Mira Meeus|last3=Versijpt|first3=Jan|author-link3=|last4=Moens|first4=Maarten|author-link4=|last5=Bos|first5=Inge|author-link5=|last6=Knaepen|first6=Kristel|author-link6=|last7=Meeusen|first7=Romain|doi=10.1517/14728222.2014.994506|pmc=|pmid=25519921|access-date=|issn=1744-7631|quote=|via=}}</ref> - [http://www.ncbi.nlm.nih.gov/pubmed/25519921 (Full text)] | *2015, Exercise and caffeine improve sustained attention following fatigue independent of fitness status<ref name="Kumar2015">{{Cite journal | title = Exercise and caffeine improve sustained attention following fatigue independent of fitness status | date = 2015-04-03 | url = https://doi.org/10.1080/21641846.2015.1027553|journal = Fatigue: Biomedicine, Health & Behavior | volume = 3 | issue = 2 | pages = 104–121 | last = Kumar | first = Namrita | last2 = Wheaton | first2 = Lewis A. | last3 = Snow | first3 = Teresa K. | last4 = Millard-Stafford | first4 = Melinda|doi=10.1080/21641846.2015.1027553|issn=2164-1846}}</ref> - [https://web.archive.org/web/20190225113231id_/http://pdfs.semanticscholar.org/61f9/b87e28a4902e1cc01250fca88dd39221256f.pdf (Full text)] | ||
*2020, DNA Methylation and Brain-Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia<ref name="Polli2020">{{Cite journal|last=Polli|first=Andrea|author-link=Andrea Polli|last2=Ghosh|first2=Manosij|author-link2=|last3=Bakusic|first3=Jelena|author-link3=|last4=Ickmans|first4=Kelly|author-link4=Kelly Ickmans|last5=Monteyne|first5=Dora|author-link5=|last6=Velkeniers|first6=Brigitte|author-link6=|last7=Bekaert|first7=Bram|last8=Godderis|first8=Lode|author-link8=Godderis Lode|last9=Nijs|first9=Jo|author-link9=Jo Nijs|date=Nov 2020|title=DNA Methylation and Brain-Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia|url=https://pubmed.ncbi.nlm.nih.gov/32562379/|journal=Arthritis & Rheumatology (Hoboken, N.J.)|volume=72|issue=11|pages=1936–1944|doi=10.1002/art.41405|issn=2326-5205|pmc=|pmid=32562379|access-date=|quote=|via=}}</ref> - [https://pubmed.ncbi.nlm.nih.gov/32562379/ (Abstract)] | *2015, Brain-derived neurotrophic factor (BDNF) as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?<ref name="Nijs2015">{{Cite journal | title = Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target? | date = Apr 2015 | url = https://pubmed.ncbi.nlm.nih.gov/25519921/ | journal = Expert Opinion on Therapeutic Targets | volume = 19 | issue = 4 | pages = 565–576 | last = Nijs | first = Jo | author-link = Jo Nijs | last2 = Meeus | first2 = Mira | author-link2 = Mira Meeus | last3 = Versijpt | first3 = Jan | author-link3 = | last4 = Moens | first4 = Maarten | author-link4 = | last5 = Bos | first5 = Inge | author-link5 = | last6 = Knaepen | first6 = Kristel | author-link6 = | last7 = Meeusen | first7 = Romain|doi=10.1517/14728222.2014.994506|pmc=|pmid=25519921|access-date=|issn=1744-7631|quote=|via=}}</ref> - [http://www.ncbi.nlm.nih.gov/pubmed/25519921 (Full text)] | ||
*2020, DNA Methylation and Brain-Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia<ref name="Polli2020">{{Cite journal | last = Polli | first = Andrea | author-link = Andrea Polli | last2 = Ghosh | first2 = Manosij | author-link2 = | last3 = Bakusic | first3 = Jelena | author-link3 = | last4 = Ickmans | first4 = Kelly | author-link4 = Kelly Ickmans | last5 = Monteyne | first5 = Dora | author-link5 = | last6 = Velkeniers | first6 = Brigitte | author-link6 = | last7 = Bekaert | first7 = Bram | last8 = Godderis | first8 = Lode | author-link8 = Godderis Lode | last9 = Nijs | first9 = Jo | author-link9 = Jo Nijs | date = Nov 2020 | title = DNA Methylation and Brain-Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia | url = https://pubmed.ncbi.nlm.nih.gov/32562379/ | journal = Arthritis & Rheumatology (Hoboken, N.J.) | volume = 72 | issue = 11 | pages = 1936–1944|doi=10.1002/art.41405|issn=2326-5205|pmc=|pmid=32562379|access-date=|quote=|via=}}</ref> - [https://pubmed.ncbi.nlm.nih.gov/32562379/ (Abstract)] | |||
==See also == | ==See also == | ||
Latest revision as of 16:11, April 3, 2023
 | This article is a stub. |
Brain-derived neurotrophic factor or BDNF is a protein in the neurotrophic family.[1] The name BDNF is also used to refer to the related gene that expresses BDNF.[1]
Function[edit | edit source]
ME/CFS[edit | edit source]
Notable studies[edit | edit source]
- 2015, Brain-derived neurotrophic factor concentration may not be depressed in chronic fatigue syndrome[2] - (Abstract)
- 2015, Exercise and caffeine improve sustained attention following fatigue independent of fitness status[3] - (Full text)
- 2015, Brain-derived neurotrophic factor (BDNF) as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?[4] - (Full text)
- 2020, DNA Methylation and Brain-Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia[5] - (Abstract)
See also[edit | edit source]
- Central sensitization
- Allodynia (pain on touch)
Learn more[edit | edit source]
- Epigenetic modification of BDNF and HDAC in pain and post-exertional malaise - ME Research UK
- Epigenetics of the BDNF gene and its relevance for pain: an exploratory study - ME Research UK
- Brain-derived neurotrophic factor (BDNF) as a driving force behind central sensitization pain: a new therapeutic target? - Jo Nijs (2015), Pain in Motion
References[edit | edit source]
- ↑ 1.0 1.1 Binder, Devin K.; Scharfman, Helen E. (September 2004). "Brain-derived Neurotrophic Factor". Growth factors (Chur, Switzerland). 22 (3): 123–131. doi:10.1080/08977190410001723308. ISSN 0897-7194. PMC 2504526. PMID 15518235.
- ↑ Patrick, David M.; Miller, Ruth R.; Steiner, Theodore; Gardy, Jennifer L.; Parker, Shoshana M.; Tang, Patrick (April 3, 2015). "Brain-derived neurotrophic factor concentration may not be depressed in chronic fatigue syndrome". Fatigue: Biomedicine, Health & Behavior. 3 (2): 122–125. doi:10.1080/21641846.2015.1024004. ISSN 2164-1846.
- ↑ Kumar, Namrita; Wheaton, Lewis A.; Snow, Teresa K.; Millard-Stafford, Melinda (April 3, 2015). "Exercise and caffeine improve sustained attention following fatigue independent of fitness status". Fatigue: Biomedicine, Health & Behavior. 3 (2): 104–121. doi:10.1080/21641846.2015.1027553. ISSN 2164-1846.
- ↑ Nijs, Jo; Meeus, Mira; Versijpt, Jan; Moens, Maarten; Bos, Inge; Knaepen, Kristel; Meeusen, Romain (April 2015). "Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?". Expert Opinion on Therapeutic Targets. 19 (4): 565–576. doi:10.1517/14728222.2014.994506. ISSN 1744-7631. PMID 25519921.
- ↑ Polli, Andrea; Ghosh, Manosij; Bakusic, Jelena; Ickmans, Kelly; Monteyne, Dora; Velkeniers, Brigitte; Bekaert, Bram; Godderis, Lode; Nijs, Jo (November 2020). "DNA Methylation and Brain-Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia". Arthritis & Rheumatology (Hoboken, N.J.). 72 (11): 1936–1944. doi:10.1002/art.41405. ISSN 2326-5205. PMID 32562379.
