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Angiotensin I converting enzyme II
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{{stub}} <span class="noglossary">'''Angiotensin I converting enzyme II'''</span> or '''ACE2''', also known as ACEH, is part of the renin-angiotensin system, which regulates [[blood pressure]], and the balance of fluids and [[electrolyte|salts]] in the body.<ref name="pubmed-gene">https://www.ncbi.nlm.nih.gov/gene/59272</ref> ==Function== The ACE2 encoding gene is believed to have a role in the carcardiovascular/circulatory system, kidney function, and fertility.<ref name="pubmed-gene" /><ref name="ACE2-GHR">https://ghr.nlm.nih.gov/gene/ACE</ref> ACE2 cuts the angiotensin I protein, convert it into angiotensin II.<ref name="pubmed-gene">https://www.ncbi.nlm.nih.gov/gene/59272</ref><ref name="ACE2-GHR" /> ==ME/CFS== Lieberman and Bell (1992) found higher serum ACE2 levels in 80% of patients with [[ME/CFS]], compared to 9.4% of controls.<ref name="Lieberman1992">https://www.sciencedirect.com/science/article/abs/pii/000293439390310L</ref > ==POTS== Musafa et al. (2012) found some patients with [[Postural orthostatic tachycardia syndrome|POTS]] have "inappropriately high plasma angiotensin II levels", and estimated that these patents had low ACE2 activity.<ref name="Musafa2012">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050076/</ref > ==COVID-19== [[Severe acute respiratory syndrome coronavirus 2|SARS-CoV-2]], the virus that causes [[COVID-19]], uses ACE2 receptors to binds to human cell.<ref name ="Yan2020">https://science.sciencemag.org/content/367/6485/1444.abstract</ref > Yan et al 2020) suggest that blocking ACE2 receptors may potentially prevent SARS-CoV-2 infection.<ref name ="Yan2020" /> ==Notable studies== * 1992, [https://www.sciencedirect.com/science/article/abs/pii/000293439390310L Serum angiotensin-converting enzyme as a marker for the chronic fatigue-immune dysfunction syndrome: A comparison to serum angiotensin-converting enzyme in sarcoidosis] *2012, [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050076/ Abnormalities of Angiotensin Regulation in Postural Tachycardia Syndrome] ==See also== *[[Postural orthostatic tachycardia syndrome]] (POTS) *[[COVID-19]] *[[Angiotensin-converting enzyme]] ==Learn more== *[https://ghr.nlm.nih.gov/gene/ACE ACE2 gene] - Genetics Home Reference, US Library of Medicine *[https://www.ncbi.nlm.nih.gov/gene/59272 ACE2 gene] - PubMed ==References== {{Reflist}} [[Category:Enzymes]] [[Category:Genes]]
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