Glutamate receptor, ionotropic, kinase 2

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
(Redirected from GRIK2)
Jump to: navigation, search

Glutamate receptor, ionotropic, kinase 2 or Glutamate Ionotropic Receptor Kainate Type Subunit 2 or GRIK2.[1][2]

Other names[edit | edit source]

  • GluK2
  • GLUR6
  • MRT6
  • Glutamate Receptor Ionotropic, Kainate 2
  • Excitatory Amino Acid Receptor 4
  • EAA4
  • Glutamate Receptor 6
  • GluR-6[1]

Function[edit | edit source]

The glutamate receptors are the main excitatory neurotransmitter receptors in the human brain, and a variety of different GRIK2 gene mutations are associated with different neurodevelopment, neurological and psychiatric conditions.[3]

ME/CFS[edit | edit source]

A small study by Smith et al. (2011) found people with the G allele of rs2247215 (GRIK2) were more likely to have chronic fatigue syndrome, and CFS patientz had decreased GRIK2 expression patients.[2]

Notable studies[edit | edit source]

  • 2011, Convergent Genomic Studies Identify Association of GRIK2 and NPAS2 with Chronic Fatigue Syndrome[2] - (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. ↑ 1.01.1 "GRIK2 Gene card". Gene cards. Retrieved April 1, 2022.
  2. ↑ 2.02.12.2 Smith, Alicia K.; Fang, Hong; Whistler, Toni; Unger, Elizabeth R.; Rajeevan, Mangalathu S. (2011). "Convergent Genomic Studies Identify Association of GRIK2 and NPAS2 with Chronic Fatigue Syndrome". Neuropsychobiology. 64 (4): 183–194. doi:10.1159/000326692. ISSN 0302-282X. PMC 3701888. PMID 21912186.
  3. ↑ "GRIK2 glutamate ionotropic receptor kainate type subunit 2 [Homo sapiens (human)] - Gene". National Center for Biotechnology Information. February 6, 2022. Retrieved March 31, 2022.

glutamate (Glu) - Glutamate is one of the amino acids used by the body to make proteins. It is a salt or ester of glutamic acid, and the terms glutamate and glutamic acid are often used interchangeably. It also functions as the principal excitatory neurotransmitter in the brain.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.

Retrieved from "https://me-pedia.org/index.php?title=Glutamate_receptor,_ionotropic,_kinase_2&oldid=204114"