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'''FITNET''' (or Fatigue In Teenagers on the interNET) consists of a series of research trials for teenagers with [[Chronic fatigue syndrome|Chronic Fatigue Syndrome]] (or [[CFS/ME]]). The FITNET clinical trials involve children aged 12 to 19 in the [[Netherlands]], with the [[United Kingdom|UK]] arm FITNET-NHS, involving children aged 11 to 17. === FITNET-NHS === FITNET-NHS "will investigate whether FITNET-NHS (online [[CBT]]) is effective in treating [[ME/CFS]] in the [[NHS]], and whether it offers value for money compared to Activity Management." FITNET-NHS plans to continue recruiting children until 2021, and recruits only children from an area without a specialist CFS service. The trial is run by [[Esther Crawley|Professor Esther Crawley]], with the research team based in Bath, UK.<ref name="ISRCTN">{{Cite web | url=http://www.isrctn.com/ISRCTN18020851 | title = ISRCTN - ISRCTN18020851: How effective is FITNET-NHS for children and young adults with CFS/ME? | last = | first = | authorlink = | date = 2018 | website = isrctn.com|language=en|archive-url=|archive-date=|url-status=|access-date=2019-02-11}}</ref> FITNET-NHS was planned with input from the charity [[Association of Young People with ME]] (AYME) and Professor [[Stephen Holgate]] supported the FITNET trial.<ref name="wames2016">{{Cite news |url =http://wames.org.uk/cms-english/2016/11/crawley-study-to-compare-online-cbt-activity-management-for-children/ | title = Crawley study to compare online CBT & activity management for children | date = 2016-11-01|work=WAMES (Working for ME in Wales)|access-date=2018-11-12|language=en-US}}</ref> However, AYME later merged with [[Action for ME]], who are not providing input to the trial. == Funding == [[National Institute for Health Research]] (NIHR) and Health Technology Assessment (HTA) Programme are funding the UK research.<ref name="bristolresearch">{{Cite web | url=http://www.bristol.ac.uk/ccah/research/childdevelopmentdisability/chronic-fatigue/fitnet-nhs/ | title = FITNET-NHS Study - overview {{!}} Centre for Academic Child Health {{!}} University of Bristol | last = Bristol | first = University of | website = bristol.ac.uk|language=en-GB|access-date=2018-11-12}}</ref> Total funding for the FITNET-NHS pilot and full trial: £994,430.<ref name="hta14192109">{{Cite web | url=https://www.journalslibrary.nihr.ac.uk/programmes/hta/14192109/#/documentation | title = Investigating the effectiveness and cost effectiveness of using FITNET to treat paediatric CFS/ME in the UK | last = Crawley | first = Esther | authorlink = Esther Crawley | date = |website=[[National Institute for Health Research]]|archive-url=|archive-date=|url-status=|access-date=2019-02-11}}</ref> == Controversy == [[David Tuller]] has written that although the [[PACE trial]] has been publicly discredited when a court-ordered release of key trial data which confirmed PACE authors "weakened their outcome criteria mid-stream in ways that allowed them to report dramatically better results for “improvement” (in ''[[The Lancet]]'' in 2011) and "recovery" (In ''Psychological Medicine'' in 2013)" they "continue to defend the indefensible study" and push forward with [[CBT]] with Dr. Esther Crawley promoting FITNET and wants to enroll more than 700 adolescents.<ref name="21nov16virology">{{Cite web | url=http://www.virology.ws/2016/11/21/trial-by-error-continued-the-new-fitnet-trial-for-kids/ | title = Trial By Error, Continued: The New FITNET Trial for Kids | date = Nov 21, 2016 | last = Tuller | first =David | authorlink =David Tuller|website=[[Virology blog]]|language=en-US|quote =}}</ref> Tuller wrote in [http://www.virology.ws/2016/11/28/trial-by-error-continued-a-follow-up-post-on-fitnet-nhs/ Trial By Error, Continued: A Follow-Up Post on FITNET-NHS] "As part of her media blitz for the FITNET-NHS launch, [[Esther Crawley |Dr. Crawley]] was interviewed on a BBC radio program by a colleague, Dr. [[Phil Hammond]]. In this interview, she made some statements that demonstrate one of two things: Either she doesn’t know what she’s talking about and her misrepresentations are genuine mistakes, or she’s lying. So either she’s incompetent, or she lacks integrity. Not a great choice." Dr. Crawley either made an "unfortunate mistake" or a "deliberate untruth" when she convoluted two comparison groups in the study; one group went on with FITNET and the other did not yet she put the groups together as all going on with FITNET. She also stated: "Now, you know, you can pick and choose how you redefine recovery, and that’s all very important research, but the message from the PACE Trial is not contested; the message is, if you want to get better, you’re much more likely to get better if you get specialist treatment." Dr. Tuller notes this is at serious odds with the facts.<ref name="28nov16virology">{{Cite web | url=http://www.virology.ws/2016/11/28/trial-by-error-continued-a-follow-up-post-on-fitnet-nhs/ | title = Trial By Error, Continued: A Follow-Up Post on FITNET-NHS | date = Nov 28, 2016 | last = Tuller | first = David | authorlink =David Tuller|website=[[Virology blog]]|language=en-US|quote=}}</ref> Excerpt of Dr. Tuller explaining facts of [[PACE trial]] data<ref name="28nov16virology" /> :In reporting their findings in The Lancet in 2011, the PACE authors presented “improvement” results for the two primary outcomes of fatigue and physical function. They reported that about 60 percent of participants in the CBT and GET arms reached the selected thresholds for “improvement” on both measures. In a 2013 paper in the journal Psychological Medicine, they presented “recovery” results based on a composite “recovery” definition that included the two primary outcomes and two additional measures. In this paper, they reported “recovery” rates for the favored intervention groups of 22 percent. :Using the raw trial data that the court ordered them to release earlier this year, the PACE authors themselves reanalyzed the Lancet improvement findings, based on their own initial, more stringent definition of “improvement” in the protocol. In this analysis, the authors reported that only about 20 percent “improved” on both measures, using the methods for assessing “improvement” outlined in the protocol. In other words, only a third as many “improved,” according to the authors’ own original definition, compared to the 60 percent they reported in The Lancet. Moreover, in the reanalysis, ten percent “improved” in the comparison group, meaning that CBT and GET led to “improvements” in only one in ten participants—a pretty sad result for a five-million-pound trial. The [[Countess of Mar]] wrote a November 3, 2016 open letter to the BBC in reference to its media coverage with Esther Crawley and FITNET. The BBC responded on November 21, 2016 and the Countess again wrote to the BBC on December 8, 2016 finding their response unsatisfactory. *Nov 3, 2016, the Countess wrote to the BBC to complain about the coverage of the FITNET ME/CFS paediatric trial run by [[Esther Crawley]].<ref name="openletterbbc">[http://www.margaretwilliams.me/2016/bbc-complaint-mar-nov16.pdf Open Letter to BBC over FITNET coverage - Nov 3, 2016]</ref> She said the reporting was "was neither accurate nor impartial" and that information on the BBC website, news bulletins & news channel were misleading. *Nov 21, 2016, The [http://www.margaretwilliams.me/2016/bbc-reply-mar-nov21.pdf BBC replied] to the Countess's letter stating that "We are aware that research about CFS has been controversial and we try to ensure that this is reflected in our coverage....I accept that the original headline for the article by [[James Gallagher]] which referred to people being ‘cured’ was incorrect. In fact it was published in error and was corrected very shortly after the original version was first posted....we decided to make reference to [the controversy] by including a clip of [[Jane Colby]] from the [[Tymes Trust]]."<ref name="bbcreply2016">[http://www.margaretwilliams.me/2016/bbc-reply-mar-nov21.pdf Response from BBC to Countess of Mar - Nov 21, 2016]</ref> *Dec 8, 2016, the Countess wrote again to the BBC about the [[FITNET]] coverage where she stated "I regret that I find your response far from satisfactory." She referenced [[David Tuller]]'s ''Trial By Error'' articles on FITNET, FITNET and the [[NHS]], flawed Dutch studies of GET/CBT and Esther Crawley.<ref name="BBCcomplaint2">[https://m.facebook.com/story.php?story_fbid=1871874666431000&id=1482582732026864 COMPLAINT TO THE BBC ABOUT FITNET COVERAGE By the Countess of Mar - Dec 8, 2016]</ref> == STOP criteria == The STOP criteria define the conditions under which the research will be halted. FITNET-NHS' STOP criteria does not include any measures of adverse experiences to participation in the trial or harm to children taking part. It does include drop-out rates from treatment. == Adverse experiences == The following events are to be recorded as adverse experiences: * == Informed consent == The participant information leaflets are available on the FITNET-NHS website, along with the informed consent forms for both teenagers and parents/carers. Previous trials involving cognitive behavioral therapy and graded exercise therapy have been criticized for not informing participants of potential risks of harm. The participant information leaflets were last updated in 2018 and does not mention: * that the [[NICE guidelines|NICE treatment guidelines]] for CFS/ME are currently being updated * what kind of adverse experiences may be expected from [[cognitive behavioral therapy]] (CBT) * what medical or professional qualifications the therapists have * rates of harm or improvement reported by adults who have undergone forms of CBT * that CBT of a form of psychotherapy * the term [[graded exercise therapy]] or graded activity is not mentioned, although the Activity Management description does state the children will be expected to increase their activity in steps of 10-20% == GP and pediatrician flyer information == FITNET-NHS provide information to GPs and pediatricians about how to refer children with ME/CFS to the FITNET-NHS trial, and some general information about the research trial. ===Most recover with specialist treatment claim === Both the FITNET-NHS posters for GPs and pediatricians include the unreferenced claim that "most" children recover within 6 months after "specialist treatment", but that "less than 10%" of children who did not attend a specialist center recovered in that time.<ref name="flyer-pediatrician">{{Cite web | url=http://www.bristol.ac.uk/media-library/sites/ccah/cfsme/study-docs/Flyer%20for%20paediatricians_v2.0.pdf | title=FITNET-NHS Paediatrician referral flyer | last = University of Bristol | first = | authorlink = University of Bristol | last2 = Royal University Hospitals Bath NHS Foundation Trust | first2 = | authorlink2 = Royal University Hospitals Bath NHS Foundation Trust|website=|archive-url=|archive-date=|url-status=|access-date=2019-02-12|quote=<strong >Treatment now available for children with CFS/ME</strong><br >1% of secondary school children miss 20% of school because of CFS/ME<br >Most will recover at 6 months with specialist treatment but less than 10% will recover without it<br >Specialist treatment is now available at home for teenagers aged 11 to 17 years with CFS/ME as part of a research study | last3 = FITNET-NHS | authorlink3 = FITNET-NHS}}</ref><ref name="flyer-GP">{{Cite web | url=http://www.bristol.ac.uk/media-library/sites/ccah/cfsme/study-docs/Flyer%20for%20GPs_v3.0.pdf | title=FITNET-NHS Flyer for GPs | last = University of Bristol | first = | authorlink = University of Bristol | last2 = Royal University Hospitals Bath NHS Foundation Trust | first2 = | authorlink2 = Royal University Hospitals Bath NHS Foundation Trust|website=|archive-url=|archive-date=|url-status=|access-date=2019-02-12|quote=<strong >Treatment now available for children with CFS/ME</strong><br >1% of secondary school children miss 20% of school because of CFS/ME<br >Most will recover at 6 months with specialist treatment but less than 10% will recover without it<br >Specialist treatment is now available at home for teenagers aged 11 to 17 years with CFS/ME as part of a research study | last3 = FITNET-NHS | authorlink3 = FITNET-NHS}}</ref> However, this claim may be based on a single study of FITNET in the Netherlands, so the figures many not be accurate for children in the UK being treated by the [[National Health Service|NHS]]. ===Recovery did not mean a return to their previous level of health === Recovery in the FITNET trial was not the rate of returning to full health; and the rate of over 60% recovery in the Dutch FITNET trial has been disputed. FITNET's trial "recovery" standard was met when the child's health was within 2 standard deviations of the norm for healthy children, this dropped to 36% of children if recovery was being within one standard deviation of the norm.<ref name="2012effective" /> FITNET's 6 month assessment period was also criticized as being too short, given that some patients have a relapsing and remitting course of illness, in which there may be some periods without symptoms before the illness returns; however longer term follow up studies have since been published.<ref name="2013followup" /> ===Patient flyer === The flyer for patients did not mention any likely rates for recovery from "specialist treatment" or without treatment. <ref name="flyer-patient">{{Cite web | url=http://www.bristol.ac.uk/media-library/sites/ccah/cfsme/study-docs/FITNET-NHS%20Poster%20Flyer%20for%20patients_v1%202018-07-12.pdf | title=FITNET-NHS poster flyer for patients | last = University of Bristol | first = | authorlink = University of Bristol | last2 = Royal University Hospitals Bath NHS Foundation Trust | first2 = | authorlink2 = Royal University Hospitals Bath NHS Foundation Trust | date = 2018-07-12 | website = |archive-url=|archive-date=|url-status=|access-date=2019-02-12|quote=Home treatment for young people with CFS/ME<br >Young people (aged 11-17) with CFS/ME can now access specialist treatment at home as part of a research study | last3 = FITNET-NHS | authorlink3 = FITNET-NHS}}</ref> ===Treatment available without joining the research trial === All these flyers mentioned that home based treatment was available for ages 11-17 "as part of a research study", none mentioned that some out of area or home based support was already able without needing to join a research trial.<ref name="flyer-pediatrician" /><ref name="flyer-patient" /><ref name="whatweoffer">{{Cite web |url = http://www.ruh.nhs.uk/patients/services/clinical_depts/paediatric_cfs_me/what_we_offer.asp | title = What we offer|quote =Treatment for those referred from further away<br >Out of our region, we may offer an original face-to-face assessment if possible, and we will then help the young person set up a rehabilitation plan. We support the child's local team in providing rehabilitation. Individuals can either be assessed as outpatients or, if they are severely affected, at home. It may not always be necessary to attend appointments in person as some may be suitable for treatment via Skype.<br >Out of region patients can also be referred for consideration and eligibility assessment for treatment at home via the FITNET-NHS trial. | last = Royal University Hospitals Bath NHS Foundation CFS/ME}}</ref> ==Protocols== The FITNET and FITNET-NHS trial protocols describe how the trial will to be conducted. The FITNET-NHS (UK) protocol has been updated a number of times, with the fifth version of the protocol published in 2019.<ref name="hta14192109" /> '''FITNET - Netherlands''' *2011, [https://doi.org/10.1186/1471-2377-11-23 Fatigue In Teenagers on the interNET - The FITNET Trial. A randomized clinical trial of web-based cognitive behavioural therapy for adolescents with chronic fatigue syndrome: study protocol.]<ref name="fitnetprotocol2011">{{Cite journal | last = Nijhof | first = Sanne L. | author-link = Sanne Nijhof | last2 = Bleijenberg | first2 = Gijs | authorlink2 = Gijs Bleijenberg | last3 = Uiterwaal | first3 = Cuno SPM | authorlink3 = Cuno Uiterwaal | last4 = Kimpen | first4 = Jan LL | authorlink4 = Jan Kimpen | last5 = van de Putte | first5 = Elise M. | authorlink5 = Elise van de Putte | date = 2011-02-19 | title = Fatigue In Teenagers on the interNET - The FITNET Trial. A randomized clinical trial of web-based cognitive behavioural therapy for adolescents with chronic fatigue syndrome: study protocol. [ISRCTN59878666]| url = https://doi.org/10.1186/1471-2377-11-23|journal=BMC Neurology|volume=11|issue=1 | pages = 23|doi=10.1186/1471-2377-11-23|issn=1471-2377|pmc=3049137|pmid=21333021|quote=|via=}}</ref> - ISRCTN59878666 '''FITNET-NHS - UK''' * 2018, [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824604/ Investigating the effectiveness and cost-effectiveness of FITNET-NHS (Fatigue In Teenagers on the interNET in the NHS) compared to Activity Management to treat paediatric chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME): protocol for a randomised controlled trial]<ref name="fitnetnhsprotocol2018">{{Cite journal | last = Baos | first = Sarah | author-link = Sarah Boas | last2 = Brigden | first2 = Amberly | authorlink2 = Amberly Brigden | last3 = Anderson | first3 = Emma | authorlink3 = Emma Anderson | last4 = Hollingworth | first4 = William | authorlink4 = William Hollingworth | last5 = Price | first5 = Simon | authorlink5 = Simon Price | last6 = Mills | first6 = Nicola | authorlink6 = Nicola Mills | last7 = Beasant | first7 = Lucy | author-link8 = Lucy Beasant | last8 = Gaunt | first8 = Daisy | author-link8 = Daisy Gaunt | last9 = Garfield | first9 = Kirsty | author-link9 = Kirsty Garfield | date = 2018-02-22 | title = Investigating the effectiveness and cost-effectiveness of FITNET-NHS (Fatigue In Teenagers on the interNET in the NHS) compared to Activity Management to treat paediatric chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME): protocol for a randomised controlled trial| url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824604/|journal=Trials|volume=19 | pages = |doi=10.1186/s13063-018-2500-3|issn=1745-6215|pmc=5824604|pmid=29471861|via=}}</ref> - ISRCTN18020851 ==Results== '''FITNET - Netherlands ''' * 2012, [http://solvecfs.org/wp-content/uploads/2014/01/FitNetRCT_Nijhof_2012_artikel5.pdf Effectiveness of internet-based cognitive behavioural treatment for adolescents with chronic fatigue syndrome (FITNET): a randomised controlled trial]<ref name="2012effective">{{Cite journal | last = van de Putte | first = Elise M. | author-link = Elise van de Putte | last2 = Kimpen | first2 = Jan LL | authorlink2 = Jan Kimpen | last3 = Uiterwaal | first3 = Cuno SPM | authorlink3 = Cuno Uiterwaal | last4 = Bleijenberg | first4 = Gijs | authorlink4 = Gijs Bleijenberg | last5 = Nijhof | first5 = Sanne L. | authorlink5 = Sanne Nijhof | date = 2012-04-14 | title = Effectiveness of internet-based cognitive behavioural treatment for adolescents with chronic fatigue syndrome (FITNET): a randomised controlled trial| url = https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60025-7/abstract|journal=The Lancet|language=English|volume=379|issue=9824 | pages = 1412–1418|doi=10.1016/S0140-6736(12)60025-7|issn=0140-6736|pmid=22385683|quote=|via=}}</ref> * 2013, [http://pediatrics.aappublications.org/content/131/6/e1788 Internet-Based Therapy for Adolescents With Chronic Fatigue Syndrome: Long-term Follow-up]<ref name="2013followup">{{Cite journal | last = van de Putte | first = Elise M. | author-link = Elise van de Putte | last2 = Kimpen | first2 = Jan L. L. | authorlink2 = Jan Kimpen | last3 = Bleijenberg | first3 = Gijs | authorlink3 = Gijs Bleijenberg | last4 = Uiterwaal | first4 = Cuno S. P.M. | last5 = Priesterbach | first5 = Loudy P. | authorlink5 = Loudy Priesterbach | last6 = Nijhof | first6 = Sanne L. | authorlink6 = Sanne Nijhof | date = 2013-06-01 | title = Internet-Based Therapy for Adolescents With Chronic Fatigue Syndrome: Long-term Follow-up | url =http://pediatrics.aappublications.org/content/131/6/e1788|journal=Pediatrics|language=en|volume=131|issue=6| pages = e1788–e1795|doi=10.1542/peds.2012-2007|issn=0031-4005|pmid=23669515|quote=|via= | authorlink4 = Cuno Uiterwaal}}</ref> * 2013, [https://academic.oup.com/painmedicine/article/14/9/1435/1879386 Functional Improvement is Accompanied by Reduced Pain in Adolescent Chronic Fatigue Syndrome]<ref name="vandeputte-pain">{{Cite journal | last = van de Putte | first = Elise M. | author-link = Elise van de Putte | last2 = Engelbert | first2 = Raoul H. | authorlink2 = Raoul Engelbert | last3 = Bleijenberg | first3 = Gijs | authorlink3 = Gijs Bleijenberg | last4 = Priesterbach | first4 = Loudy P. | authorlink4 = Loudy Priesterbach | last5 = Nijhof | first5 = Sanne L. | authorlink5 = Sanne Nijhof | date = Sep 1, 2013 | title = Functional Improvement Is Accompanied by Reduced Pain in Adolescent Chronic Fatigue Syndrome | url =https://academic.oup.com/painmedicine/article/14/9/1435/1879386|journal=Pain Medicine|language=en|volume=14|issue=9 | pages = 1435–1438|doi=10.1111/pme.12181|issn=1526-2375|quote=|via=}}</ref> '''FITNET - UK ''' * ==Criticism== * 2017, [http://www.mdpi.com/2076-328X/7/3/52 FITNET’s Internet-Based Cognitive Behavioural Therapy Is Ineffective and May Impede Natural Recovery in Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. A Review] by [[Simin Ghatineh]] and [[Mark Vink]]<blockquote>'''Abstract:''' The Dutch Fatigue In Teenagers on the interNET (FITNET) study claimed that after 6 months, internet based cognitive behaviour therapy in adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), led to a 63% recovery rate compared to 8% after usual care, and that this was maintained at long term follow up (LTFU). Our reanalysis shows that their post-hoc definition of recovery included the severely ill, the unblinded trial had no adequate control group and it used lax selection criteria as well as outcomes assessed via quqqestionnaires rather than objective outcomes, further contributing to exaggerated recovery figures. Their decision not to publish the actometer results might suggest that these did not back their recovery claims. Despite these bias creating methodological faults, the trial still found no significant difference in recovery rates (“~60%”) at LTFU, the trial’s primary goal. This is similar to or worse than the documented 54–94% spontaneous recovery rates within 3–4 years, suggesting that both FITNET and usual care (consisting of cognitive behaviour and graded exercise therapies) are ineffective and might even impede natural recovery in adolescents with ME/CFS. This has implications for the upcoming costly NHS FITNET trial which is a blueprint of the Dutch study, exposing it to similar biases.<ref>{{Cite journal | last = Ghatineh | first = Simin | author-link = Simin Ghatineh | last2 = Vink | first2 = Mark | authorlink2 = Mark Vink | date = 2017-08-11 | title = FITNET’s Internet-Based Cognitive Behavioural Therapy Is Ineffective and May Impede Natural Recovery in Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. A Review | url = http://www.mdpi.com/2076-328X/7/3/52|journal=Behavioral Sciences|language=en|volume=7|issue=4 | pages = 52|doi=10.3390/bs7030052|issn=2076-328X|pmc=5618060|pmid=28800089|quote=Abstract: The Dutch Fatigue In Teenagers on the interNET (FITNET) study claimed that after 6 months, internet based cognitive behaviour therapy in adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), led to a 63% recovery rate compared to 8% after usual care, and that this was maintained at long term follow up (LTFU). Our reanalysis shows that their post-hoc definition of recovery included the severely ill, the unblinded trial had no adequate control group and it used lax selection criteria as well as outcomes assessed via questionnaires rather than objective outcomes, further contributing to exaggerated recovery figures. Their decision not to publish the actometer results might suggest that these did not back their recovery claims. Despite these bias creating methodological faults, the trial still found no significant difference in recovery rates (“~60%”) at LTFU, the trial’s primary goal. This is similar to or worse than the documented 54–94% spontaneous recovery rates within 3–4 years, suggesting that both FITNET and usual care (consisting of cognitive behaviour and graded exercise therapies) are ineffective and might even impede natural recovery in adolescents with ME/CFS. This has implications for the upcoming costly NHS FITNET trial which is a blueprint of the Dutch study, exposing it to similar biases.|via=}}</ref></blockquote> * 2018, [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824604/ Investigating the effectiveness and cost-effectiveness of FITNET-NHS (Fatigue In Teenagers on the interNET in the NHS) compared to Activity Management to treat paediatric chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME): protocol for a randomised controlled trial]<ref name="fitnetnhsprotocol2018" /> == Investigators == === FITNET-NHS (UK) === * Chief investigator: [[Esther Crawley]] * Co-investigators: [[Hans Knoop]], [[David Kessler]], [[Elise Van de Putte]], [[Nicola Mills]], [[Sanne Nijhof]], [[Harriet Downing]], [[Chris Metcalfe]], [[Gijs Bleijenberg]], [[John Macleod]], [[Paul Stallard]], [[William Hollingworth]].<ref name="hta14192109" /> == Learn more == *[http://www.bristol.ac.uk/ccah/research/childdevelopmentdisability/chronic-fatigue/fitnet-nhs/ FITNET-NHS trial] - Bristol University == See also == *[[CMRC]] *[[Biopsychosocial model]] *[[Cognitive behavioral therapy]] *[[Graded exercise therapy]] *[[Outcome switching]] == References == {{reflist}} [[Category:Psychological paradigm]] [[Category:Potential treatments]] [[Category:Notable studies]]
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