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Bee venom therapy
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'''Bee venom therapy''' or '''BVT''' or '''bee sting therapy''' or '''apitherapy''' is an alternative treatment proposed to result in possible health benefits in some medical conditions,<ref name="Jang2020" /><ref name="Park2015" /> although it has not been proposed or investigated in patients with [[ME/CFS]]. It is sometimes used in traditional Korean medicine.<ref name="Jang2020" /> Bee venom therapy can take several different forms: * live bee stings under the supervision of a trained practioner * bee venom acupuncture (BVA), or * bee venom injections<ref name="Jang2020">{{Cite journal | title = Clinical Effectiveness and Adverse Events of Bee Venom Therapy: A Systematic Review of Randomized Controlled Trials | date = Sep 2020 | url = https://www.mdpi.com/2072-6651/12/9/558 | journal = Toxins | volume = 12 | issue = 9 | pages = 558 | last = Jang | first = Soobin | author-link = | last2 = Kim | first2 = Kyeong Han | author-link2 = | last3 = | first3 = | author-link3 = | author-link4 = | last5 = | first5 = | author-link5 = | last7 = | first7 = | language=en|doi=10.3390/toxins12090558|pmc=PMC7551670|pmid=32872552|access-date=|issn=2072-6651|quote=|via=}}</ref> ==Theory== ==Evidence== Clinical trials have not been conducted for ME/CFS patients so potential harms have not been identified,<ref name="Jang2020" /> and it is not known if this would be safe or effective. A randomized crossover study of bee sting therapy in patients with [[multiple sclerosis]] by Wesselius et al. (2005) reported: :"There was no improvement of [[disability]], [[fatigue]], and quality of life. Bee sting therapy was well tolerated, and there were no serious adverse events."<ref name="Wesselius2005">{{Cite journal | title = A randomized crossover study of bee sting therapy for multiple sclerosis | date = 2005-12-13 | url = https://n.neurology.org/content/65/11/1764 | journal = Neurology | volume = 65 | issue = 11 | pages = 1764–1768 | last = Wesselius | first = T. | last2 = Heersema | first2 = D.J. | last3 = Mostert | first3 = J.P. | last4 = Heerings | first4 = M. | last5 = Admiraal-Behloul | first5 = F. | last6 = Talebian | first6 = A. | last7 = Buchem | first7 = M. A. van | last8 = Keyser | first8 = J. De|language=en|doi=10.1212/01.wnl.0000184442.02551.4b|pmid=16221950|issn=0028-3878}}</ref> ==Clinicians== The use of bee venom therapy for ME/CFS patients has not been proposed or investigated by researchers or specialists in ME/CFS treatment, although a variety of other conventional and [[alternative medicine|alternative treatments]] have been investigated.<ref name="altnutrition2000">{{Cite journal | date = May 2000 | url = https://www.researchgate.net/profile/Mel-Werbach/publication/12548254_Nutritional_strategies_for_treating_chronic_fatigue_syndrome/links/59ea9d3eaca272cddddb8318/Nutritional-strategies-for-treating-chronic-fatigue-syndrome.pdf | title=Nutritional Strategies for Treating Chronic Fatigue Syndrome | journal = Alternative Medicine Review | first = Melvyn R. | last = Werbach|language=en | volume = 5 | issue = 2 | pages = 93-108|quote=|via=}}</ref><ref name="Porter2010">{{Cite journal | last = Porter | first = Nicole S. | author-link = Nicole Porter | last2 = Jason | first2 = Leonard A. | author-link2 = Leonard Jason | last3 = Boulton | first3 = Aaron | author-link3 = | last4 = Bothne | first4 = Nancy | author-link4 = | last5 = Coleman | first5 = Blair | author-link5 = | date = Mar 2010 | title = Alternative medical interventions used in the treatment and management of myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia | url = https://www.researchgate.net/profile/Leonard_Jason/publication/41655043_Alternative_Medical_Interventions_Used_in_the_Treatment_and_Management_of_Myalgic_EncephalomyelitisChronic_Fatigue_Syndrome_and_Fibromyalgia/links/5581c5b408ae6cf036c16e0b/Alternative-Medical-Interventions-Used-in-the-Treatment-and-Management-of-Myalgic-Encephalomyelitis-Chronic-Fatigue-Syndrome-and-Fibromyalgia.pdf | journal=Journal of Alternative and Complementary Medicine (New York, N.Y.) | volume = 16 | issue = 3 | pages = 235–249|doi=10.1089/acm.2008.0376|issn=1557-7708|pmc=|pmid=20192908|access-date=|quote=|via=}}</ref> ==Risks and safety== Unknown in ME/CFS patients, however clinical trials in other patient groups have shown high levels of adverse reactions.<ref name="Jang2020" /><ref name="Park2015">{{Cite journal | title = Risk Associated with Bee Venom Therapy: A Systematic Review and Meta-Analysis | date = 2015-05-21 | url = https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126971 | journal = PLOS ONE | volume = 10 | issue = 5| pages = e0126971 | last = Park | first = Jeong Hwan | last2 = Yim | first2 = Bo Kyung | last3 = Lee | first3 = Jun-Hwan | last4 = Lee | first4 = Sanghun | last5 = Kim | first5 = Tae-Hun|language=en|doi=10.1371/journal.pone.0126971|pmc=PMC4440710|pmid=25996493|issn=1932-6203}}</ref> Live bee stings involve apply bee venom directly to the skin (not injecting it) and has a high risk of adverse reactions. Bee venom acupuncture, which involves injecting bee venom diluted to a ratio of less than 1:10,000 to acupoints has a significantly lower rate of side effects.<ref name="Jang2020" /> ==Costs and availability== ==See also== * [[Allergy]] * [[Mast cell activation syndrome]] (MCAS) * [[Alternative medicine]] ==Learn more== <!-- *Outside articles: e.g. WebMD, Merck Manual, drugs.com, drugbank.ca, Memorial Sloan Kettering, or ScienceDirect --> ==References== {{reflist}} [[Category:Potential treatments]] [[Category:Alternative medicine]] [[Category:Traditional Korean medicine]]
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