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Christopher Larrimore
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==Research== On a two-year research fellowship from the Johns Hopkins University, Larrimore investigated blood vessel growth in response to tumor formation.<ref name=":0" /> After matriculation into medical school, he began pursuing ME research on a one-year research fellowship at NSU-KPCOM.<ref name=":0" /> His current ME research examines genetics and a hypothesized role of 5-MTHF (active [[folate]], [[methylfolate]], or [[Vitamin B9]]) in people with ME.<ref name=":0" /> [[Methylation]] is a mechanism central to the functioning of numerous biochemical pathways, including in cardiovascular, neurological, reproductive, energy production and detoxification biochemical systems.<ref name=":0" /> If a genetic variant reducing available 5-[[MTHFR]] is present, it reduces the body's ability to activate these systems, possibly producing fatigue such as seen in the clinical presentation of ME.<ref name=":0" /> To examine this possible link to ME, Larrimore used a genetic database developed by Dr. [[Nancy Klimas]]βs team at the NSU [[Institute of Neuro-Immune Medicine]] to identify persons with a MTHFR gene mutation and recruit for a small, proof-of-concept study of the role of folate in ME.<ref name=":0" /> Over three months in a double-blinded study, subjects took either daily methylfolate supplement or a placebo and outcomes were measured both by serum biomarkers and self-reported symptoms. In July 2019, he was awarded a Blue Ribbon Fellowship from [[The MEAction Network]] to continue this project.<ref name=":0" />
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