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Jo Nijs
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=== An increased reactivity of the central nervous system === Nijs suspects pain in ME/CFS might be explained be the process of '[[central sensitization]]' (CS). This refers to a heightened responsiveness of the central nervous system (CNS) to nociceptive stimuli. Because no lesions or neural damage can be found to explain the pain of ME/CFS patients, it is assumed that the CNS overreacts to normal stimuli, seeing them as more threatening than they are. According to Nijs this might explain why ME/CFS patients often perceive painful stimuli as more intense ([[hyperalgesia]]) or experience pain after normally innocuous stimuli ([[allodynia]]). Nijs has argues that CS might also explain other symptoms besides pain, such as the sensitivity to light, sound and various chemicals that many ME/CFS patients display.<ref name="NijsMind2012" />
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