Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Valaciclovir
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
'''Valaciclovir''' (UK) or '''valacyclovir''' (US) is a generic [[antiviral]] drug used against most [[herpesviruses]]. It does not cure herpes, but helps reduce the viral expression, by interrupting the replication of viral [[DNA]].<ref>[https://en.wikipedia.org/wiki/Valaciclovir Wikipedia - Valaciclovir]</ref> Valaciclvir is the international nonproprietary name used by the [[World Health Organization]] (WHO). The non-generic or trade names are Valtrex and Zelitrex, manufactured by GlaxoSmithKline. It is available by prescription only, worldwide, and is administered orally. Once in the body, valaciclovir is converted to [[aciclovir]] (UK) or [[acyclovir]] (US). Treatment with Valacyclovir reduces the number of [[Epstein-Barr virus]]-infected [[B cell]]s, but not the number of EBV DNA copies within each infected cell.<ref name="yo2009" /> ==Use in ME/CFS== Some [[ME/CFS]] specialists prescribe valaciclovir to help mitigate the effects of the [[Epstein-Barr virus]] which may be reactivated in ME/CFS. Dr. [[A Martin Lerner]] studied the efficacy of higher doses of Valtrex on ME/CFS and concluded that it increased physical functioning, improved [[heart]] functioning, and decreased [[Epstein-Barr virus]] antibody levels. <ref name=":0">{{Cite web|url=http://www.cfstreatmentguide.com/1/post/2015/04/dr-martin-lerners-treatment-protocol-for-mecfs.html | title = Dr. Martin Lerner's Treatment Protocol for ME/CFS|website=CFS Treatment Guide|language=en|access-date=2020-10-08 | date = | last = | first = | authorlink = |archive-url=https://web.archive.org/web/20190214142932/http://treatmentcenterforcfs.com/documents/MECFSTreatmentResourceGuideforPractitioners.pdf|archive-date=2019|url-status=}}</ref> Valtrex inhibits the replication of HH-1, HH-2, HH-3, HH-4 (Herpes simplex (HSV-1, HSV-2), Herpes Zoster (VZV), Epstein Barr (EBV)) and has seen improvements in 85% of ME/CFS patients. Among adolescents, the outcome was even better with 92% responding. Only one patient experienced nausea and discontinued the antiviral. Improvement occurred over the course of 3-5 months with 85% percent of the patients responding by 3 months, and 92% by 5 months. Symptoms of fatigue, exertion induced malaise, excessive sleep, napping, unrefreshing sleep, headaches, cognitive symptoms, and emotional symptoms all resolved.<ref>Henderson, Theodore A. “Valacyclovir treatment of chronic fatigue in adolescents.” Advances in mind-body medicine vol. 28,1 (2014): 4-14.</ref><ref>[https://www.psychiatryadvisor.com/home/opinion/the-role-of-antiviral-therapy-in-chronic-fatigue-treatment/ The Role of Antiviral Therapy in Chronic Fatigue Treatment], Theodore Henderson, MD, PhD, March 2015 </ref> In Dr Lerner's IIMEC3 presentation his slides discuss using Famciclovir at similar dosages to Valtrex. He states in his slides that Famciclovir, "can be substituted and although there is not the strong evidence that we have for valacyclovir, it likely is equally effective." <ref name=":0" /> ==See also== *[[Acyclovir]] *[[Herpesviruses]] *Valganclovir *[https://me-pedia.org/wiki/Famciclovir Famciclovir] ==Learn more== *[https://en.wikipedia.org/wiki/Valaciclovir Wikipedia - Valaciclovir] *[https://cfsremission.wordpress.com/2016/04/06/valacyclovir-ebv-and-cfs/ Valacyclovir, EBV and CFS] *[http://www.pdr.net/full-prescribing-information/Valtrex-valacyclovir-hydrochloride-233 Physician's Desk Reference - Valtrex] *[http://treatmentcenterforcfs.com/documents/MECFSTreatmentResourceGuideforPractitioners.pdf ME/CFS Treatment Resource Guide for Practitioners by Dr. A Martin Lerner] *[http://www.drmyhill.co.uk/wiki/Valacyclovir_in_the_treatment_of_post_viral_fatigue_syndrome#Treatment_regimes Doctor Sarah Myhill - Valacyclovir in the treatment of post viral fatigue syndrome] ==References== <references> <ref name="yo2009">{{Citation| doi = 10.1128/JVI.01005-09| issn = 0022-538X| volume = 83 | issue = 22| pages = 11857–11861| last1 = Hoshino | first1 = Yo | last2 = Katano | first2 = Harutaka | last3 = Zou | first3 = Ping | last4 = Hohman | first4 = Patricia | last5 = Marques | first5 = Adriana | last6 = Tyring | first6 = Stephen K. | last7 = Follmann | first7 = Dean | last8 = Cohen | first8 = Jeffrey I.| title = Long-Term Administration of Valacyclovir Reduces the Number of Epstein-Barr Virus (EBV)-Infected B Cells but Not the Number of EBV DNA Copies per B Cell in Healthy Volunteers| journal = Journal of Virology| access-date = 2016-11-09| date = November 2009| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772668/| pmid = 19740997| pmc = 2772668}}</ref> </references> [[Category:Potential treatments]] [[Category:Antivirals]]
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Templates used on this page:
Template:Citation
(
edit
)
Template:Cite web
(
edit
)
Module:Citation/CS1
(
edit
)
Module:Citation/CS1/COinS
(
edit
)
Module:Citation/CS1/Configuration
(
edit
)
Module:Citation/CS1/Date validation
(
edit
)
Module:Citation/CS1/Identifiers
(
edit
)
Module:Citation/CS1/Utilities
(
edit
)
Module:Citation/CS1/Whitelist
(
edit
)
Module:No globals
(
edit
)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs