Post-exertional malaise: Difference between revisions

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'''Post-exertional malaise''' (PEM) is a worsening of many [[ME/CFS]] symptoms as a result of physical or mental exertion.  It is often referred to as "The Marker" by patients, ME/CFS organizatons, and clinicians and researchers that work in the ME/CFS field.<ref>[http://www.fightingfatigue.org/post-exertional-malaise-a-hallmark-symptom-of-mecfs/ Fighting Fatigue: Post-Exertional Malaise – A Hallmark Symptom of ME/CFS]</ref><ref>[http://www.cortjohnson.org/about-chronic-fatigue-syndrome-mecfs/symptoms/ Health Rising: Symptoms]</ref>
'''Post-exertional malaise''' (PEM) is a worsening of many [[ME/CFS]] symptoms as a result of physical or mental exertion.  It is often referred to as "the marker" by patients, ME/CFS organizatons, and clinicians and researchers that work in the ME/CFS field.<ref name="JohnsonCsymptoms"/><ref name="FightFatiguePEM"/>


==Notable studies==
==Notable studies==
*Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression<ref>[http://www.tandfonline.com/doi/abs/10.1080/21641846.2013.838444 Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression - Taylor & Francis Online - Fatigue: Biomedicine, Health & Behavior]</ref>
*[http://www.tandfonline.com/doi/abs/10.1080/21641846.2013.838444 Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression], ''Meyer et al'', 2013<ref name="MeyerJ2013"/>
*Myalgic Encephalomyelitis: Symtoms and Biomarkers - Jasona et al., Current Neuropharmacology<ref name="ME_symptoms_biomarkers" />
*[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761639/#!po=2.51799 Myalgic Encephalomyelitis: Symptoms and Biomarkers], ''Jason et al'', 2015<ref name="JasonL2015bio"/>
*Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - Shukla et al., Plos One<ref name="Microbiome_Changes" />
*[http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0145453 Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)], ''Shukla et al'', 2015<ref name="ShuklaS2015"/>


==Notable articles==
==Notable articles==
*Suggestion to replace PEM by PAR (Post Activity Relapse) - ME Blogg <ref>[http://me-cfs.se/blogg/suggestion-to-replace-pem-by-par/ Suggestion to replace PEM by PAR - Author "Befria Mig!", ME Blogg, December 2015]</ref>
*[http://me-cfs.se/blogg/suggestion-to-replace-pem-by-par/ Suggestion to replace PEM (Post Exertional Malaise) with PAR (Post Activity Relapse)], ''ME Blogg'', 2015<ref name="MEBlogg2015"/>


==Talks & interviews==
==Talks & interviews==
*Post-Exertion Malaise: The Intersection of Biology and Behavior - Dr. [[Dane Cook]], [[Solve ME/CFS]], November 2015 youtube<ref>[https://www.youtube.com/watch?v=vfmrPd4-rIE&feature=youtu.be Post-Exertion Malaise: The Intersection of Biology and Behavior - Dr. Dane Cook, Solve ME/CFS, November 2015 youtube]</ref>  
*[https://www.youtube.com/watch?v=vfmrPd4-rIE Post-Exertion Malaise: The Intersection of Biology and Behavior], ''[[Dane Cook]], [[Solve ME/CFS]]'', 2015<ref name="CookD20151119v"/>


==Learn more==
==Learn more==
*2013, [http://solvecfs.org/wp-content/uploads/2013/10/pem-series.pdf PEM series] ([[Jennie Spotila]])
*[http://solvecfs.org/wp-content/uploads/2013/10/pem-series.pdf Post-Exertional Malaise in Chronic Fatigue Syndrome], ''[[Jennie Spotila]], [[Solve ME/CFS]]'', 2010<ref name="SpotilaJ2010"/>
*[http://solvecfs.org/post-exertional-malaise-cause-and-effect/ Post-exertional malaise cause and effect]
*[http://solvecfs.org/post-exertional-malaise-cause-and-effect/ Post-Exertional Malaise: Cause and Effect], ''[[Jennie Spotila]], [[Solve ME/CFS]]'', 2012<ref name="SpotilaJ20120523"/>
*[http://chronicfatigue.about.com/od/cfsglossary/g/malaise.htm Post-Exertional Malaise About.com FMS/ME/CFS]
*[http://chronicfatigue.about.com/od/cfsglossary/g/malaise.htm Definition of Post-Exertional Malaise], ''About Health'', 2015<ref name="AboutHealthPEM"/>


==See also==
==See also==
Line 21: Line 21:


== References ==
== References ==
[[Category:Signs and symptoms]]
<references>
<references>
<ref name="ME_symptoms_biomarkers">{{Citation
 
| last1  = Jasona            | first1 = LA.                  | authorlink1 = Leonard A. Jasona
<ref name="AboutHealthPEM">{{citation
| last2  = Zinn              | first2 = ML.                    | authorlink2 = Marcie L. Zinn
| author  = About Health
| last3  = Zinn              | first3 = MA.                      | authorlink3 = Mark A. Zinn
| title  = Definition of Post-Exertional Malaise
| display-authors = 1
| date    = 8 Oct 2015
| title  = Myalgic Encephalomyelitis: Symtoms and Biomarkers
| url    = http://chronicfatigue.about.com/od/cfsglossary/g/malaise.htm
}}</ref>
 
<ref name="CookD20151119v">{{citation
| last1  = Cook              | first1 = DB                  | authorlink1 = Dane Cook
| title  = Deciphering Post Exertion Malaise: The Intersection of Biology and Behavior
| type    = video
| journal = Solve ME/CFS
| date    = 19 Nov 2015
| url    = https://www.youtube.com/watch?v=vfmrPd4-rIE
}}</ref>
 
<ref name="FightFatiguePEM">{{citation
| author  = Fighting Fatigue
| title  = Post-Exertional Malaise – A Hallmark Symptom of ME/CFS
| access-date = Mar 2016
| url    = http://www.fightingfatigue.org/post-exertional-malaise-a-hallmark-symptom-of-mecfs/
}}</ref>
 
<ref name="JasonL2015bio">{{Citation
| last1  = Jason            | first1 = LA                 | authorlink1 = Leonard A Jason
| last2  = Zinn              | first2 = ML                 | authorlink2 = Marcie L Zinn
| last3  = Zinn              | first3 = MA                 | authorlink3 = Mark A Zinn
| display-authors = 3
| title  = Myalgic Encephalomyelitis: Symptoms and Biomarkers
| journal = Current Neuropharmacology    | volume = 13(5)    | page = 701-734
| journal = Current Neuropharmacology    | volume = 13(5)    | page = 701-734
| date    = September 2015
| date    = September 2015
| pmid    =
| doi    = 10.2174/1570159X13666150928105725
| doi    = 10.2174/1570159X13666150928105725
| url    = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761639/#!po=2.51799
| url    = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761639/#!po=2.51799
}}</ref>
}}</ref>
<ref name="Microbiome_Changes">{{Citation
 
| last1  = Shukla            | first1 = SK                 | authorlink1 = Sanjay K. Shukla
<ref name="JohnsonCsymptoms">{{citation
| last2  = Cook              | first2 = D                 | authorlink2 = Dane Cook
| last1  = Johnson          | first1 = C                | authorlink1 = Cort Johnson
| last3  = Meyer            | first3 = J                 | authorlink3 = Jacob Meyer  
| title  = Health Rising: ME/CFS Symptoms
| last4  = Vernon            | first4 = SD                 | authorlink3 = Suzanne D. Vernon
| access-date = Mar 2016
| last5  = Lee              | first5 = T                 | authorlink3 = Thao Lee
| url    = http://www.cortjohnson.org/about-chronic-fatigue-syndrome-mecfs/symptoms/
| last6  = Clevidence        | first6 = D                 | authorlink3 = Derek Clevidence
}}</ref>
| last7  = Robertson        | first7 = CE                 | authorlink3 = Charles E. Robertson
 
| last8  = Schrodi          | first8 = SJ                 | authorlink3 = Steven J. Schrodi
<ref name="MEBlogg2015">{{citation
| last9  = Yale              | first9 = S                 | authorlink3 = Steven Yale
| author  = ME Blogg
| last10   = Frank           | first10 = DN               | authorlink3 = Daniel N. Frank
| title  = Suggestion to replace PEM by PAR
| display-authors = 1
| date    = 30 Dec 2015
| url    = http://me-cfs.se/blogg/suggestion-to-replace-pem-by-par/
}}</ref>
 
<ref name="MeyerJ2013">{{citation
| last1  = Meyer            | first1 = JD                  | authorlink1 = Jacob D Meyer
| last2  = Alan              | first2 = AR                  | authorlink2 = Alan R Light
| last3  = Shukla            | first3 = SK                  | authorlink3 = Sanjay K Shukla
| last4  = Clevidence        | first4 = D                  | authorlink4 = Derek Clevidence
| last5  = Yale              | first5 = S                  | authorlink5 = Steven Yale
| last6  = Stegner          | first6 = AJ                  | authorlink6 = Aaron J Stegner
| last7  = Cook              | first7 = DB                  | authorlink7 = Dane Cook
| display-authors = 7
| title  = Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression
| journal = Fatigue: Biomedicine, Health & Behavior | volume = 1 | issue = 4 | page = 190-209
| date    = 2 Oct 2013
| doi    = 10.1080/21641846.2013.838444
| url    = http://www.tandfonline.com/doi/abs/10.1080/21641846.2013.838444
}}</ref>
 
<ref name="ShuklaS2015">{{Citation
| last1  = Shukla            | first1 = SK                 | authorlink1 = Sanjay K Shukla
| last2  = Cook              | first2 = D                   | authorlink2 = Dane Cook
| last3  = Meyer            | first3 = JD                 | authorlink3 = Jacob D Meyer  
| last4  = Vernon            | first4 = SD                 | authorlink4 = Suzanne D Vernon
| last5  = Lee              | first5 = T                   | authorlink5 = Thao Lee
| last6  = Clevidence        | first6 = D                   | authorlink6 = Derek Clevidence
| last7  = Robertson        | first7 = CE                 | authorlink7 = Charles E Robertson
| last8  = Schrodi          | first8 = SJ                 | authorlink8 = Steven J Schrodi
| last9  = Yale              | first9 = S                   | authorlink9 = Steven Yale
| last10 = Frank             | first10= DN                 | authorlink10= Daniel N Frank
| display-authors = 3
| title  = Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
| title  = Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
| journal = Plos One    | volume = 10(12)    | page =  
| journal = Plos One    | volume = 10(12)    | page =  
Line 54: Line 107:
| url    = http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0145453
| url    = http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0145453
}}</ref>
}}</ref>
</references>
 
<ref name="SpotilaJ2010">{{citation
| last1  = Spotila          | first1 = JM                  | authorlink1 = Jennie Spotila
| title  = Post-Exertional Malaise in Chronic Fatigue Syndrome
| journal = Solve ME/CFS
| date    = 2010
| url    = http://solvecfs.org/wp-content/uploads/2013/10/pem-series.pdf
}}</ref>
 
<ref name="SpotilaJ20120523">{{citation
| last1  = Spotila          | first1 = JM                  | authorlink1 = Jennie Spotila
| title  = Post-Exertional Malaise: Cause and Effect
| journal = Solve ME/CFS
| date    = 23 May 2012
| url    = http://solvecfs.org/post-exertional-malaise-cause-and-effect/
}}</ref>
 
 
 
 
[[Category:Signs and symptoms]]

Revision as of 14:20, March 29, 2016

Post-exertional malaise (PEM) is a worsening of many ME/CFS symptoms as a result of physical or mental exertion. It is often referred to as "the marker" by patients, ME/CFS organizatons, and clinicians and researchers that work in the ME/CFS field.[1][2]

Notable studies[edit | edit source]

Notable articles[edit | edit source]

Talks & interviews[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

<references>

[10]

[7]

[2]

[4]

[1]

[6]

[3]

[5]

[8]

[9]

  1. ↑ 1.0 1.1 Johnson, C, Health Rising: ME/CFS Symptoms, retrieved Mar 2016 Check date values in: |access-date= (help)
  2. ↑ 2.0 2.1 Fighting Fatigue, Post-Exertional Malaise – A Hallmark Symptom of ME/CFS, retrieved Mar 2016 Check date values in: |access-date= (help)
  3. ↑ 3.0 3.1 Meyer, JD; Alan, AR; Shukla, SK; Clevidence, D; Yale, S; Stegner, AJ; Cook, DB (October 2, 2013), "Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression", Fatigue: Biomedicine, Health & Behavior, 1 (4): 190-209, doi:10.1080/21641846.2013.838444 Invalid |display-authors=7 (help)
  4. ↑ 4.0 4.1 Jason, LA; Zinn, ML; Zinn, MA (September 2015), "Myalgic Encephalomyelitis: Symptoms and Biomarkers", Current Neuropharmacology, 13(5): 701-734, doi:10.2174/1570159X13666150928105725 Invalid |display-authors=3 (help)
  5. ↑ 5.0 5.1 Shukla, SK; Cook, D; Meyer, JD; et al. (December 18, 2015), "Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)", Plos One, 10(12), doi:10.1371/journal.pone.0145453
  6. ↑ 6.0 6.1 ME Blogg (December 30, 2015), Suggestion to replace PEM by PAR
  7. ↑ 7.0 7.1 Cook, DB (November 19, 2015), "Deciphering Post Exertion Malaise: The Intersection of Biology and Behavior", Solve ME/CFS (video)
  8. ↑ 8.0 8.1 Spotila, JM (2010), "Post-Exertional Malaise in Chronic Fatigue Syndrome" (PDF), Solve ME/CFS
  9. ↑ 9.0 9.1 Spotila, JM (May 23, 2012), "Post-Exertional Malaise: Cause and Effect", Solve ME/CFS
  10. ↑ 10.0 10.1 About Health (October 8, 2015), Definition of Post-Exertional Malaise

post-exertional malaise (PEM) - A notable exacerbation of symptoms brought on by small physical or cognitive exertions. PEM may be referred to as a "crash" or "collapse" and can last for days or weeks. Symptoms can include cognitive impairments, muscle pain, trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, and others.

post-exertional malaise (PEM) - A notable exacerbation of symptoms brought on by small physical or cognitive exertions. PEM may be referred to as a "crash" or "collapse" and can last for days or weeks. Symptoms can include cognitive impairments, muscle pain, trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, and others.

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