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Mast cell
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=== Mast cell activation syndrome === {{Main article|page_name=Mast cell activation syndrome}} [[Mast cell activation syndrome]] (MCAS) is a condition in which mast cells are over-responsive to various environmental triggers. When mast cells are over-responsive the result can be an increase in the release of [[histamine]] and other inflammatory molecules. Excessive inflammation can result from such a condition. MCAS is often found in patients with [[Ehlers-Danlos syndrome]] (EDS) and [[postural orthostatic tachycardia syndrome]] (POTS), a form of [[orthostatic intolerance]],<ref>Milner, Joshua, Dr. "Research Update: POTS, EDS, MCAS Genetics." 2015 Dysautonomia International Conference & CME. Washington DC. Dysautonomia International Research Update: POTS, EDS, MCAS Genetics. Web. <https://vimeo.com/142039306></ref> two conditions commonly co-morbid with [[ME/CFS|ME]]. The overlap between EDS, POTS, and MCAS is thought to be due to increased [[tryptase]] production owing to an extra copy of a gene called TPSAB.<ref name="Cheung2015">{{Cite journal | last = Cheung|first = Ingrid | date = Feb 2015 | title = A New Disease Cluster: Mast Cell Activation Syndrome, Postural Orthostatic Tachycardia Syndrome, and Ehlers-Danlos Syndrome|url=http://www.jacionline.org/article/S0091-6749(14)02927-3/abstract|journal=The Journal of Allergy and Clinical Immunology|volume=|pages=|via=}}</ref> MCAS should be distinguished from [[mastocytosis]], a genetic disorder causing excessive production of mast cells.
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