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Candida Albicans Overgrowth hypothesis
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==Evidence== [[Candida albicans]] overgrowth in the stomach and bowel might be a root cause for a [[metabolic trap]] leading to reduced ability to convert glucose to cell energy, similar to the [[Warburg effect]]<ref>{{Cite journal | last = van der Heiden | first = Matthew G. | last2 = Cantley | first2 = Lewis C. | last3 = Thompson | first3 = Craig B. | date = May 2009 | title = Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation | url =http://science.sciencemag.org/content/324/5930/1029 | journal = Science}}</ref>. It is also suggested that [[candida albicans]] overgrowth could be caused by an antibiotic treatment after an infection<ref>{{Cite journal | last = Zelante | first = Teresa | last2 = Iannitti | first2 = Rossana G. | last3 = Cunha | first3 = Cristina | last4 = De Luca | first4 = Antonella | last5 = Giovannini | first5 = Gloria | last6 = Pieraccini | first6 = Giuseppe | last7 = Zecchi | first7 = Riccardo | last8 = DβAngelo | first8 = Carmen | last9 = Massi-Benedetti | first9 = Cristina | date = Aug 2013 | title = Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22 | url = https://linkinghub.elsevier.com/retrieve/pii/S1074761313003312 | journal = Immunity | volume = 39 | issue = 2 | pages = 372β385|doi=10.1016/j.immuni.2013.08.003|issn=1074-7613|quote=|via=}}</ref>. In addition, it is also mentioned that the amino acid [[tryptophan]] could be inhibited by [[candida albicans]] overgrowth.<ref>{{Cite journal | last = Romani | first = Luigina | author-link = | last2 = Zelante | first2 = Teresa | author-link2 = | last3 = De Luca | first3 = Antonella | author-link3 = | last4 = Iannitti | first4 = Rossana G. | author-link4 = | last5 = Moretti | first5 = Silvia | author-link5 = | last6 = Bartoli | first6 = Andrea | last7 = Aversa | first7 = Franco | last8 = Puccetti | first8 = Paolo | date = Nov 2014 | title = Microbiota control of a tryptophan-AhR pathway in disease tolerance to fungi | url = https://www.ncbi.nlm.nih.gov/pubmed/25256754 | journal = European Journal of Immunology | volume = 44 | issue = 11 | pages = 3192β3200|doi=10.1002/eji.201344406|issn=1521-4141|pmid=25256754|quote=|via=}}</ref> This may activate the immune system, causing sense of illness and fatigue<ref>{{Cite journal | last = Roager | first = Henrik M. | last2 = Licht | first2 = Tine R. | date = Aug 2018 | title = Microbial tryptophan catabolites in health and disease | url =https://www.nature.com/articles/s41467-018-05470-4 | journal = Nature}}</ref>. Treatment of the [[candida albicans]] overgrowth using [[probiotics]]/[[antimycotics]] or [[tryptophan]] was not effective, and a specific [[diet]] (low [[carbohydrate]], fat rich etc.) in addition to [[turmeric]] mixtures was suggested for treatment during 3-4 months.<ref>{{citation | last = Berstad | first = Arnold | date = Nov 14, 2018 | title = IBS, fibromyalgia and ME: Symptoms, patogenesis and treatment |url= https://www.facebook.com/me.oafyl/videos/1947735378865298/ | publisher = Norwegian ME Association }}</ref>
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