Talk:Cytokine storm

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references -- ~Njt (talk) 18:09, April 20, 2020 (PDT)[edit source | reply | new]

"Exuberant immune responses induced following infection have been described as a “cytokine storm,” associated with excessive levels of proinflammatory cytokines and widespread tissue damage." - Guo and Thomas (2017) PMC5580809

"The term "cytokine storm” to describe an immune response to influenza infection was first used in late 2003 in reference to influenza-associated encephalopathy [3] [4]. Thus far, the influenza-induced cytokine storm has been linked to uncontrolled proinflammatory responses, which induce significant immunopathology and severe disease outcomes [5] [6] [7] [8]." - Guo and Thomas (2017) [1]PMC5580809

Term first used in 2003 - [2]Yokota (2003) in Japanese

"The term 'cytokine storm' is now used in popular culture as an explanation for the distinctly unpleasant feeling we all sense at the onset of flu. The expression certainly has common currency, with 21 000 Google hits 12 months ago and 55 000 at the time of writing this article. The two-part Special Feature in the January and February issues of Immunology and Cell Biology acknowledges that the sense of this term, with the added complexity of knowing that the mediators involved are also necessary, at lower concentrations, for innate immunity to function, has finally come of age. While the articles on HIV, hepatitis, flaviviruses, tuberculosis, toxoplasmosis, shigellosis, schistosomiasis and visceral leishmaniasis essentially concern local pathological events from these cytokines, those on poxviruses, dengue, influenza and malaria describe variants of the consequences of a systemic response. Salmonella, because of its range of serovars, has a foot in each camp. The interesting omission is sepsis. Research into this condition has never managed to gain a foothold in some countries, despite it being the major cause of death in intensive care units in all first world countries and a part of the cytokine storm literature since 1981." - [3]Clark (2007) doi: 10.1038/sj.icb.7100062

Merrian-Webster Medical Dictionary:

the uncontrolled, sometimes life-threatening, excessive release of cytokines (such as chemokines, interferons, or interleukins) in the body from an aggressive, pro-inflammatory immune response resulting from overreaction of the immune system (as to an infectious disease or immunotherapy)[4]

~Njt (talk) 18:09, April 20, 2020 (PDT)

Added to ~Njt (talk) 16:06, February 19, 2021 (UTC)

  1. Guo, XJ; Thomas, PG (2017). "New fronts emerge in the influenza cytokine storm". Semin Immunopathol. 39 (5): 541–550. doi:10.1007/s00281-017-0636-y. PMC 5580809. PMID 28555383.
  2. Yokota, S (2003). "[Influenza-associated encephalopathy--pathophysiology and disease mechanisms]". Nihon Rinsho. 61 (11): 1953–1958. PMID 14619437.
  3. Clark IA (2007). "The advent of the cytokine storm". Immunol Cell Biol. 85 (4): 271–3. doi:10.1038/sj.icb.7100062. PMID 17551531.
  4. Merriam-Webster Medical Dictionary. "Definition of CYTOKINE". Merrian-Webster Dictionary. Retrieved February 19, 2021.
  5. Wang, Q; Fang, P; He, R; Li, M; Yu, H; Zhou, L; et al. (2020). "O-GlcNAc transferase promotes influenza A virus-induced cytokine storm by targeting interferon regulatory factor-5". Sci Adv. 6 (16): eaaz7086. doi:10.1126/sciadv.aaz7086. PMC 7159909. PMID 32494619.