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Needs citations adding, rewording in encyclopedic style, and this content needs moving into the Hormones category page (2018)
Anecdotally, some sufferers of CFS/ME find help in supplementing with Melatonin. Melatonin, also known as N-acetyl-5-methoxy tryptamine, is a hormone that is produced by the pineal gland in animals and regulates sleep and wakefulness. Those supplementing with Melatonin report better, deeper sleep. Sufferers report the effect of Melatonin supplementation is not immediate and should be tried for a few weeks before determining if it mitigates sleep problems. Supplementation can range from 1 mg/day to 10 mg/day and perhaps higher as studies involving breast cancer patients have supplemented with 20 mg/day. Melatonin supplementation should be done in conjunction with your physician's advice.
Vitamin D would also be a good hormone to supplement for ME/CFS sufferers. Low Vitamin D has been linked to many diseases including MS (multiple sclerosis which like ME is a neuroimmune disease). Optimal Vitamin D range is 50 – 80 ng/mL. Vitamin D can be tested with a simple, inexpensive blood test by a physician. A good process to follow is to have your physician test your Vitamin D level and then begin supplementation. Typical supplementation varies by individual and ranges from 1,000 IU per day to 10,000 IU per day. After supplementing for 90 days, have your physician retest and continue this process by increasing your dose until you reach at least 50 ng/mL on your test.
Restoring youthful hormone levels may be helpful for those sufferers over 25 years of age, as hormone levels peak in late teens/early 20s. Restoration should only be done with bioidentical hormones. Hormones to ask your physician about should include DHEA, Testosterone, Progesterone, Estradiol, Estriol, and Pregnenolone. Estriol and Estradiol are typically supplemented in an 80/20 ratio. Hormone level can be assessed via urine, saliva, and blood. Each type of test has pros and cons.
Notable studies[edit | edit source]
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References[edit | edit source]
- "hormone | Definition, Function, & Types". Encyclopedia Britannica. Retrieved Apr 10, 2019.
- Wyller, Vegard Bruun; Evang, Johan Arild; Godang, Kristin; Solhjell, Kari K.; Bollerslev, Jens (Jun 2010). "Hormonal alterations in adolescent chronic fatigue syndrome". Acta Paediatrica (Oslo, Norway: 1992). 99 (5): 770–773. doi:10.1111/j.1651-2227.2010.01701.x. ISSN 1651-2227. PMID 20199497.
Myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.