Human papilloma virus (HPV) vaccines are vaccines that prevent infection by certain types of human papillomavirus. Available vaccines protect against either two, four, or nine types of HPV. All vaccines protect against at least HPV type 16 and 18 that cause the greatest risk of cervical cancer.
Controversy[edit | edit source]
- 2012, The HPV Vaccine Controversy
- 2013, HPV Vaccine Controversy
- 2014, Pros, cons, and ethics of HPV vaccine in teens—Why such controversy?
Notable research[edit | edit source]2018, Autonomic dysfunction and HPV immunization: an overview. (ABSTRACT)
This article reviews the case series reported from several countries describing patients with suspected severe side effects to the HPV vaccines. The described symptom clusters are remarkably similar and include disabling fatigue, headache, widespread pain, fainting, gastrointestinal dysmotility, limb weakness, memory impairment episodes of altered awareness, and abnormal movements. This constellation of symptoms and signs has been labeled with different diagnoses such as complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), small fiber neuropathy (SFN), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), or fibromyalgia. It is known that autoimmunity and autoantibodies are present in a subset of patients with CRPS, POTS, SFN, ME/CFS, and fibromyalgia. This article proposes that vaccine-triggered, immune-mediated autonomic dysfunction could lead to the development of de novo post-HPV vaccination syndrome possibly in genetically susceptible individuals. Being cognizant that a temporal relationship between vaccination and symptom onset does not necessarily equate to causality, mounting evidence of case series calls for well-designed case-control studies to determine the prevalence and possible causation between these symptom clusters and HPV vaccines. Since personalized medicine is gaining momentum, the use of adversomics and pharmacogenetics may eventually help identify individuals who are predisposed to HPV vaccine adverse events.
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- "Weekly epidemiological record". apps.who.int (PDF). World Health Organization. May 12, 2017.
- Kash, Natalie; Lee, Michael A.; Kollipara, Ramya; Downing, Christopher; Guidry, Jacqueline; Tyring, Stephen K. (Apr 3, 2015). "Safety and Efficacy Data on Vaccines and Immunization to Human Papillomavirus". Journal of Clinical Medicine. 4 (4): 614–633. doi:10.3390/jcm4040614. ISSN 2077-0383. PMC . PMID 26239350.
- Edgar, Julie. "Should Your Child Get the HPV Vaccine?". WebMD. Retrieved Nov 29, 2018.
- Intlekofer, Karlie A.; Cunningham, Michael J.; Caplan, Arthur L. (Jan 1, 2012). "The HPV Vaccine Controversy". AMA Journal of Ethics. 14 (1). ISSN 2376-6980.
- "HPV Vaccine Controversy". The Doctors. Dec 9, 2013. Retrieved Nov 29, 2018.
- White, Mark Donald (2014). "Pros, cons, and ethics of HPV vaccine in teens—Why such controversy?". Translational Andrology and Urology. 3 (4): 429–434. doi:10.3978/j.issn.2223-4683.2014.11.02. ISSN 2223-4691. PMC . PMID 26816799.
- Blitshetyn, Svetlana; Brinth, Louise; Hendrickson, Jeanne E.; Martinez-Lavin, Manuel (Nov 27, 2018). "Autonomic dysfunction and HPV immunization: an overview". Immunologic Research. doi:10.1007/s12026-018-9036-1. ISSN 1559-0755. PMID 30478703.
Adverse reaction - Any unintended or unwanted response to the treatment under investigation in a clinical trial.
Postural orthostatic tachycardia syndrome (POTS) - A form of orthostatic intolerance where the cardinal symptom is excessive tachycardia due to changing position (e.g. from lying down to sitting up).
World Health Organization (WHO) - "A specialized agency of the United Nations that is concerned with public health. It was established on 7 April 1948, and is headquartered in Geneva, Switzerland. The WHO is a member of the United Nations Development Group. Its predecessor, the Health Organization, was an agency of the League of Nations." The International Statistical Classification of Diseases and Related Health Problems (ICD) is maintained by WHO.