File:White blood cells in MECFS NK.jpg

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Leucocyte gating strategy for phenotypic characterisation of PBMC. Thawed PBMC from Biobank participants were stained with labelled antibodies (Supplementary Table S2), expression data were collected by Flow cytometry and analysed using FlowJo. (A) Single cells were gated based on their forward scatter height and area, and (B) monocytes within the single cell gate were identified as CD14+. (C) Dendritic cells were identified within the CD3-CD14- cell population as myeloid (CD11c+) or plasmacytoid (CD123+) DCs. (D) Lymphocytes were identified based on their forward and side scatter area profiles, and B cells were identified as CD19+ (E), T cells as CD3+ (F), and NK cells as CD56+ (G). Within the NK cell gate, NK cells were characterised further based on NKG2C (H), NKp46 (I), and CD57 (J) co-expression.

Author: (or citation)[edit | edit source]

Cliff JM, King EC, Lee J-S, Sepúlveda N, Wolf A-S, Kingdon C, Bowman E, Dockrell HM, Nacul L, Lacerda E and Riley EM (2019) Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Front. Immunol. 10:796. doi: 10.3389/fimmu.2019.00796

Figure 1

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https://www.frontiersin.org/articles/10.3389/fimmu.2019.00796/full

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antibodies Antibody/immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

antibodies Antibody/immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

B cell B lymphocyte, or a type of white blood cell, which is involved in the immune response by secreting antibodies to ward off infections. In mammals, they are mostly matured in the bone marrow.

T cell A type of white blood cell which is mostly produced or matured in the thymus gland (hence T-cell) and is involved in the adaptive immune response on a cellular level. Also known as a T lymphocyte. (Learn more: www.youtube.com)

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

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current13:16, June 27, 2020Thumbnail for version as of 13:16, June 27, 20201,084 × 767 (435 KB)Notjusttired (talk | contribs)==== Title: (or description) ==== Leucocyte gating strategy for phenotypic characterisation of PBMC. Thawed PBMC from Biobank participants were stained with labelled antibodies (Supplementary Table S2), expression data were collected by Flow cytome...

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