File:TRPM3-sensingpain.png

Summary[edit | edit source]

TRPM3, TRP channel activation and pain.

Description: Effects of the activation of TRP channels in sensory neurons by lipopolysaccharides (LPS). LPS triggers activation the sensory nervous system by activation of TRPA1, TRPV1 and/or TRPM3 located at peripheral nerve terminals. TRPM8 activation by LPS occurs at cold temperatures. Sensory nerve activation leads to action potential generation and pain, and the local release of neuropeptides leading to neurogenic inflammation. CGRP, calcitonin gene-related peptide; SP, substance P.

Author: Boonen et al (2018. Citation: Toxins 2018, 10(8), 326; https://doi.org/10.3390/toxins10080326 Source: TRP Channels as Sensors of Bacterial Endotoxins Fig 2 https://www.mdpi.com/2072-6651/10/8/326

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