File:Kynurenine pathway.jpg
Kynurenine_pathway.jpg (561 × 569 pixels, file size: 196 KB, MIME type: image/jpeg)
The Kynurenine pathway. IDO catabolizes indole compounds, including Trp and 5-hydroxytryptamine. Enzymes (blue) downstream of IDO generate bioactive catabolites called kynurenines. Immune and CNS cells express sensors (red) that detect these metabolic changes to impact immunologic and neurologic processes.
Citation: Mellor AL, Lemos H and Huang L (2017) Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now? Front. Immunol.8:1360. doi: 10.3389/fimmu.2017.01360 Source: https://www.frontiersin.org/articles/10.3389/fimmu.2017.01360/full
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